13 Best Nootropics For Anxiety

Last Updated:
Medically reviewed by Dr. Harshi Dhingra

Key Information

Nootropics are natural or synthetic compounds that enhance cognition

They can improve memory, focus, mood, creativity, and motivation.

Nootropics can help reduce anxiety and stress levels

They can modulate neurotransmitters, hormones, and brain waves that are involved in anxiety and stress response.

Nootropics can have different effects depending on the individual

Some nootropics may work better for some people than others, depending on their brain chemistry, genetics, and lifestyle.

Nootropics should be used with caution and research

They can have side effects, interactions, and contraindications. They should not replace professional medical advice or treatment.

Affiliate Disclosure: Holistic Nootropics may earn affiliate commissions if you purchase through the links on this page. Here's how it works.

Hey there!

As you probably already know, nootropics can be potent agents for managing anxiety.
The big question is which nootropic works best for you and your particular anxiolytic need.
To help, I spent over 50 hours researching and testing different compounds in addition to interviewing experts in the field to find the best nootropics for anxiety.
In the following article, I briefly describe the 13 best nootropics for anxiety, how they work, and help you understand how to use them for optimal results.
If you’re eager to learn more about some brain-boosting nootropics, let’s jump into it!

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What Are The Best Nootropics for Anxiety – Quick Answers

Mind Lab Pro #1

Mind Lab Pro

Science-backed nutrition for your brain
Check PriceBuy 3 bottles, get 1 free with our links
NooCube #2


Maximize your mental performance for peak productivity
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Magnesium Breakthrough #3

Magnesium Breakthrough

#1 Magnesium Product
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Blood Sugar Breakthrough by Bioptimizers #4

Blood Sugar Breakthrough by Bioptimizers

#1 Blood Sugar Support Supplement
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Rhodiola Rosea by Nootropics Depot #5

Rhodiola Rosea by Nootropics Depot

natural way to reduce fatigue
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Bromantane by SwissChem #6

Bromantane by SwissChem

Anxiety Crusher
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Alpha Brain by Onnit #7

Alpha Brain by Onnit

Stabilizes and promotes healthy blood sugar levels
Check PriceLimited time offer: Free 15 day trial
L-Theanine by Nootropics Depot #8

L-Theanine by Nootropics Depot

The all-natural "chill pill"
Taurine by Nootropics Depot #9

Taurine by Nootropics Depot

The miracle ingredient in energy drinks
Check PriceGet 5% off entire order w/ code HOLISTICNOOTROPICS
Acetyl L-Carnitine (ALCAR) by Nootropics Depot #10

Acetyl L-Carnitine (ALCAR) by Nootropics Depot

Boost energy levels and athletic performance
Check PriceGet 5% off entire order w/ code HOLISTICNOOTROPICS
Reishi by Real Mushrooms #11

Reishi by Real Mushrooms

Calming, Mood Enhancing
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Ashwagandha by Nootropics Depot #12

Ashwagandha by Nootropics Depot

Most Powerful Stress Resistance Herb
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NAC #13


Powerful mood stabilizer

Best Nootropics For Anxiety Frequently Asked Questions

Best Nootropics For Anxiety

Science-backed nutrition for your brain

Mind Lab Pro

Mind Lab Pro
Shop NowBuy 3 bottles, get 1 free with our links
Shop NowBuy 3 bottles, get 1 free with our links
  • Boost mental performance

  • Support a calm mindset and relaxation

  • Increase memory, focus, creativity, and energy levels

  • Reduce anxiety and improve sleep


  • Proven to boost overall cognitive performance including memory, focus, mood, creativity, motivation, and overall well-being.
  • Potent blend of all-natural nootropics, herbs, amino acids, vitamins, and minerals.
  • Good for experienced biohackers and those new to nootropics.
  • Caffeine Free
  • No artificial fillers or toxic preservatives
  • Affordable Price, money back guarantee


  • Ingredients are lower dosed.

Mind Lab Pro is a powerful nootropic supplement designed to help reduce feelings of anxiety and calm the mind. Each of its ingredients has been carefully selected for its ability to improve various aspects of mental health, including focus, memory, mood, and cognition.

Some of the key ingredients in Mind Lab Pro include citicoline, phosphatidylserine, and Bacopa monnieri. Citicoline works by increasing levels of important neurotransmitters like acetylcholine in the brain, which are known to play a role in reducing feelings of anxiety. Meanwhile, phosphatidylserine helps to promote healthy communication between brain cells and regulate stress hormone levels. Finally, Bacopa monnieri is well-known for its powerful antioxidant properties that can combat oxidative damage caused by stress and other environmental factors.

Along with these natural ingredients, Mind Lab Pro also includes a number of other potent nootropics like L-theanine, rhodiola rosea, and a mix of B vitamins. These compounds work together to enhance cognition and improve overall mental performance. They can also help to reduce feelings of anxiety and promote feelings of calmness and relaxation without the need for prescription drugs like Xanax.

Overall, I highly recommend Mind Lab Pro as an alternative treatment for anxiety that is both safe and effective. Whether you are struggling with occasional bouts of worry or full-blown panic attacks, this versatile nootropic supplement can help you regain control over your mind so you can feel confident and focused again in all areas of your life.

Maximize your mental performance for peak productivity


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  • Improves oxygenation, nutrient absorption and stimulate neurotransmitter production for better cognitive function

  • Stimulates the production of neurotransmitters

  • Supports increases in concentration, learning, short-term memory, and problem-solving

  • Reduce age-related cognitive decline while improving overall mental performance

NooCube is a revolutionary dietary supplement that provides cognitive benefits to help people with their everyday tasks.

It contains a unique blend of natural ingredients such as Lutemax, Bacopa monnieri, Huperzia Serrata, Pterostilbene, Resveratrol, L-theanine, L-tyrosine, Alpha GPC, Oat straw extract, Cat’s claw, Vitamin B1, Vitamin B7, and Vitamin B12.

Lutemax is derived from lutein and zeaxanthin and helps support optimal health by helping the body absorb light better. Bacopa monnieri helps boost memory and concentration by supporting neurotransmitters in the brain.

Huperzia Serrata boosts mental clarity by making it easier for your brain to process information quickly and accurately. Pterostilbene helps preserve healthy brain cells, while Resveratrol promotes overall brain health.

L-theanine works in combination with caffeine to provide more focused alertness without the jittery side effects generally associated with the caffeine alone.

L-Tyrosine aids in reducing mental fatigue, while alpha GPC helps improve memory formation after exercise or physical stress. Oat straw extract helps increase mental energy levels while cat’s claw supports cognitive function through its anti-inflammatory properties. Vitamins B1 (thiamin), B7 (biotin), and B12 (cobalamin) support healthy nervous system functioning crucial for all aspects of neural communication within the brain.

NooCube combines this unique blend of natural ingredients to create an effective solution for people looking to boost their focus and concentration when performing daily tasks or studying for exams or projects.

By providing improved cognitive abilities without the dangerous side effects of other prescription drugs, NooCube is an easy alternative for anyone looking to get ahead in life without risking their long-term health or productivity levels.

As someone who has used NooCube regularly, I can confidently say that it has made an incredible difference in my day-to-day life since taking it regularly over the past few months.

The combination of natural ingredients has allowed me to focus on my tasks throughout the day while providing increased energy levels so I can stay productive longer into the night if needed.

Overall I think NooCube is one of the best supplements out there right now – allowing people to boost their cognitive abilities safely and naturally – which is why I highly recommend it.


  • Preformulated for easy access to essential nootropics
  • Best value for nootropic cognitive enhancement
  • All-natural ingredients with no fillers/preservatives
  • Includes B-vitamins for enhanced metabolism


  • Some ingredients may be underdosed for specific nootropic therapy

#1 Magnesium Product

Magnesium Breakthrough

Magnesium Breakthrough
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  • Magnesium restores balance to the mind and body

  • Improves symptoms of ADHD in some people

  • Triggers relaxation response

  • Steadies the mind for restful sleep


  • Includes the 7 most effective forms of magnesium
  • Highly credible manufacturer
  • No added fillers, preservatives, or unnecessary ingredients
  • Free shipping and discounts are available


  • Underdosed for specific magnesium type you may want

One systematic review from 2017 found a significant link between high levels of anxiety and low levels of magnesium 1Neil Bernard Boyle, The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review, Nutrients 2017.

Magnesium regulates neurotransmitters in the brain. It primarily affects the hypothalamus, an area of the brain responsible for stress response 2Neil Bernard Boyle , Clare L Lawton, Louise Dye, The effects of magnesium supplementation on subjective anxiety, Magnes Res. 2016 3Anna E Kirkland , Gabrielle L Sarlo , Kathleen F Holton, The Role of Magnesium in Neurological Disorders, Nutrients. 2018.

Magnesium supplementation can, therefore, help ease anxiety symptoms and improve stress management 4Neil Bernard Boyle , Clare L Lawton, Louise Dye, The effects of magnesium supplementation on subjective anxiety, Magnes Res. 2016 5Anna E Kirkland , Gabrielle L Sarlo , Kathleen F Holton, The Role of Magnesium in Neurological Disorders, Nutrients. 2018

#1 Blood Sugar Support Supplement

Blood Sugar Breakthrough by Bioptimizers

Blood Sugar Breakthrough by Bioptimizers
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  • Most potent blend of blood sugar stabilizing ingredients on the market today

  • 100mg of Dihydroberberine per serving (2 capsules)

  • Supports Stable Blood Sugar Levels

  • All-Natural ingredients including herbals, amino acids, vitamins, and minerals

  • Product manufactured in USA according to highest GMP-certified standards

  • 30 servings per bottle (2 capsules/serving)

  • Free shipping and added discounts available

If you’re looking for a natural way to regulate your blood sugar and improve your ADHD symptoms, Blood Sugar Breakthrough may be worth trying!

Blood Sugar Breakthrough is a potent Adderall replacement as it helps stabilize your body and brain’s glucose metabolism.

Researchers have found a correlation between ADHD and blood sugar which makes sense since the ADHD brain craves dopamine stimulation that can be obtained through simple carbs and high-sugar foods. You’ve most likely experienced moments of hunger where you found it impossible to focus.6Mark F McCarty, James J DiNicolantonio , Neuroprotective potential of high-dose biotin, Med Hypotheses. 2017

Unstable blood glucose levels enhance this craving and deprive your brain of the dopamine it needs. Blood Sugar Breakthrough optimizes your body’s glycemic response to food which helps stabilize your blood sugar and focus.7NIH, Chromium, NIH. 20218Kate Petersen Shay, Régis F. Moreau,1 Eric J. Smith, Anthony R. Smith, and Tory M. Hagen, Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential, Biochim Biophys Acta. 2009

This formula also has some natural, cognition-stimulating ingredients, such as biotin, chromium, and alpha-lipoic acid, which can boost overall cognition.


  • Contains natural ingredients that have been clinically proven to help lower blood sugar levels
  • Has been shown to help people lose weight
  • comes with a money-back guarantee, so you can feel confident that you’re not wasting your money if it doesn’t work for you
  • Produced by BiOptimizers, one of the most trusted names in the Supplement Industry


  • Can be a bit pricey
  • Encapsulation includes magnesium stearate, and silicon dioxide (not toxic at low levels, but not 100% clean)

Anxiety Crusher

Bromantane by SwissChem

Bromantane by SwissChem
Shop Now$10 Off With Code HolisticNootropics
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  • Bromantane strengthens GABA-ergic neurotransmission in the brain

  • Like many pharmaceuticals, Bromantane can normalize the benzodiazepine site of the GABA receptor

  • Shown to produce more beneficial dopamine and serotonin neurotransmission.

  • Affordable price, fast-shipping

natural way to reduce fatigue

Rhodiola Rosea by Nootropics Depot

Rhodiola Rosea by Nootropics Depot
Check PriceGet 5% off entire order w/ code HOLISTICNOOTROPICS
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  • Used in traditional medicine for centuries

  • Natural way to improve mental performance and stamina

  • Can help reduce fatigue

Rhodiola Rosea is a perennial plant that grows in cold, mountainous regions of Europe and Asia. Also known as “golden root” or “roseroot,” Rhodiola Rosea has been used for centuries in traditional medicine to treat various conditions, including fatigue, anxiety, and depression. Today, Rhodiola Rosea supplements are marketed as natural ways to boost energy levels and improve mental performance. But what does the science say?

There is some evidence to suggest that Rhodiola Rosea supplements can improve mental stamina and help reduce fatigue.

One study found that Rhodiola Rosea improved mental performance in physicians working night shifts. another study found that Rhodiola Rosea improved physical stamina and reduced fatigue in long-distance runners. The mechanisms by which Rhodiola Rosea may exert these effects are not fully understood, but it is thought that the plant’s active compounds, known as rosavins, may work to increase levels of certain neurotransmitters in the brain, including dopamine and serotonin.

While more research is needed to confirm the potential benefits of rhodiola rosea supplements, there is some promise here.

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Alpha Brain by Onnit

Alpha Brain by Onnit
Shop NowLimited time offer: Free 15 day trial
Shop NowLimited time offer: Free 15 day trial
  • Alpha Brain delivers a blend of potent nootropics that promote alpha brain waves and improved cognitive function

  • The formula includes L-Theanine, phosphatidylserine, L-tyrosine, cats claw, be it in a propriety form

  • There are no artificial additives, flavors, sweeteners, colors, caffeine, dairy or gluten in the product

  • Keto and paleo diet friendly

Alpha Brain is a nootropic supplement created by Joe Rogan’s well-known supplement company Onnit. As such, its probably the most hyped, most heavily marketed nootropic stack on the planet.

We like Alpha Brain because not only does it provide natural ingredients to help boost cognitive enhancement but it also offers many other benefits such as improved brain energy levels and enhanced concentration skills; plus its easy-to-take capsules make taking it on a daily basis simple! On the other hand, some people may not be fans of Alpha Brain due to its proprietary blends since those looking for full transparency may not be satisfied with what they see on the label.

I personally have tried out Alpha Brain and noticed huge improvements in my focus levels after a few weeks of consistent usage; this allowed me to power through difficult tasks with much more ease than before taking it.

Alpha Brain was designed to enhance cognitive functions, such as focus, concentration, and memory. It contains various natural ingredients that have been carefully selected in order to give the optimal boost for peak mental performance.

The primary ingredient in Alpha Brain is Alpha GPC or Alpha glycerylphosphorylcholine. This is a choline-enhancing compound that helps to replenish the neurotransmitter acetylcholine, which aids in memory formation and recall. Another beneficial ingredient is Huperzia Serrata, an extract from Chinese club moss which has been used for centuries for its cognitive-enhancing properties.

Bacopa Monnieri, another key ingredient found in Alpha Brain, has been clinically proven to improve memory retention and comprehension. L-Theanine and L-Tyrosine are amino acids that help increase alertness and reduce stress.

Oat Straw Extract, Phosphatidylserine, Cat’s Claw Extract (AC-11), Pterostilbene, and L-Leucine are all additional ingredients found in Alpha Brain that aid in improving mental clarity and focus while maintaining overall brain health.

Finally, Vitamin B6 promotes energy production throughout the body while helping to prevent fatigue caused by extended periods of concentration or mental strain.

It is recommended to take two capsules of Alpha Brain daily after a light meal for optimal results.

However, it can take up to several weeks before you begin feeling any noticeable effects depending on your individual circumstances so patience is key when trying this supplement out for the first time.

The all-natural “chill pill”

L-Theanine by Nootropics Depot

  • L-theanine is a natural and powerful nootropic that can help improve cognition and mental clarity.

  • It has the unique ability to both reduce stress and anxiety while enhancing alertness and focus.

  • It balances key neurotransmitters in the brain for a sense of relaxation and deep focus.

  • It does not cause addiction or have serious side effects like some other stimulants.

  • Taking 200 mg per day can significantly reduce fatigue, boost cognitive performance, and provide an overall improved mental state.

L-Theanine is an amino acid that can be found in tea leaves. L-Theanine has been shown to provide a variety of cognitive benefits, including reducing anxiety.

The mechanisms by which L-Theanine provides these benefits is thought to work by modulating levels of the neurotransmitter GABA. GABA is a neurotransmitter that plays a role in anxiety and stress response.

L-Theanine supplements have been shown to be effective in reducing anxiety in a variety of populations, including healthy adults, people with anxiety disorders, and even children.

If you’re looking for a natural way to reduce anxiety, L-Theanine supplements may be worth considering.

The miracle ingredient in energy drinks

Taurine by Nootropics Depot

Taurine by Nootropics Depot
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Check PriceGet 5% off entire order w/ code HOLISTICNOOTROPICS
  • Commonly found in many energy drinks and supplements

  • Can improve mental focus and physical performance

  • Helps to protect the brain from age-related damage and oxidative stress


  • Proven to boost energy, endurance, and focus
  • Promotes healthy metabolism
  • Helps protect the eyes against retinal degeneration
  • Safe and effective nootropic supplement with a wide range of potential benefits


  • Large doses may cause gastrointestinal distress
  • Cause some side effects such as headaches, insomnia, and anxiety.

Taurine is an amino acid that is found in the body found in the body and increases the calming neurotransmitter GABA in the brain.9Abdeslem El Idrissi , Latifa Boukarrou, Wally Heany, George Malliaros, Chaichan Sangdee, Lorenz Neuwirth, Effects of taurine on anxiety-like and locomotor behavior of mice, Adv Exp Med Biol. 200910Gao-Feng Wu, Shuang Ren,# Ri-Yi Tang,Chang Xu, Jia-Qi Zhou, Shu-Mei Lin, Ying Feng, Qun-Hui Yang, Jian-Min Hu and Jian-Cheng Yang, Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats, Sci Rep. 2017

It is also found in some foods, such as meat and fish.

Taurine has many functions in the body, including: helping to keep the heart healthy, aiding in the development of the nervous system, and helping to prevent anxiety.

There are many benefits of taking taurine supplements for anxiety. Taurine has been shown to help reduce anxiety and improve mood. It can also help to improve cognitive function and reduce stress levels.

Taurine works great in someone with mood instability accompanied by anxiety, but it is also helpful for anxiety alone.

Taurine is a safe, effective, and affordable anxiety treatment that can help you get your life back on track.

Boost energy levels and athletic performance

Acetyl L-Carnitine (ALCAR) by Nootropics Depot

Acetyl L-Carnitine (ALCAR) by Nootropics Depot
Check PriceGet 5% off entire order w/ code HOLISTICNOOTROPICS
Check PriceGet 5% off entire order w/ code HOLISTICNOOTROPICS
  • Improve cognitive function

  • Protect the brain from damage

  • Boost energy levels

  • Enhance athletic performance

If you’re looking for an alternative treatment for anxiety, you may want to consider L-Carnitine supplements.

L-Carnitine is an amino acid that is produced in the liver and kidney.

L-Carnitine supplements are often marketed as a weight loss aid, but there is little scientific evidence to support this claim.

However, there is some evidence to suggest that L-Carnitine supplements may have cognitive benefits:

Recently, L-Carnitine had promising results in a clinical trial evaluating it as a treatment for depression 11Carla Nasca, Benedetta Bigio, Francis S. Lee, Sarah P. Young, Marin M. Kautz, Ashly Albright, James Beasley, David S. Millington, Aleksander A. Mathé, James H. Kocsis, James W. Murrough, Bruce S. McEwen, and Natalie Rasgon, Acetyl-l-carnitine deficiency in patients with major depressive disorder, PNAS August 21, 2018.

Other preclinical studies showed its potential for anxiety as well12Joseph Levine, Zeev Kaplan, Jay W. Pettegrew, Richard J. McClure, Samuel Gershon, Igor Buriakovsky, Hagit Cohen, Effect of intraperitoneal acetyl-L-carnitine (ALCAR) on anxiety-like behaviours in rats, International Journal of Neuropsychopharmacology. 2005 13Lais Pancotto, Ricieri Mocelin, Matheus Marcon, Ana P. Herrmann, and Angelo Piato, Anxiolytic and anti-stress effects of acute administration of acetyl-L-carnitine in zebrafish, PeerJ. 2018

The mechanism of action for the cognitive benefits of L-Carnitine lies in its ability to cross the blood-brain barrier and increase levels of acetylcholine, a neurotransmitter involved in memory and learning.

Calming, Mood Enhancing

Reishi by Real Mushrooms

Reishi by Real Mushrooms
Buy from Freshcap15% Off order with code holisticnootropics
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  • Promotes long-term focus and mental energy

  • Stimulate neurogenesis

  • Boosts immune system

  • Calm effects on central nervous system


  • May help improve sleep quality and reduce stress levels
  • Can be consumed in many different forms, such as capsules, powders, teas, and tinctures
  • Used in Asia for centuries as a medicinal mushroom


  • Common side effects include gastrointestinal upset and nausea
  • Not recommended for people with autoimmune disease or taking immunosuppressive medication

Reishi Mushrooms are a staple of Eastern medicine.

Also known as Ganoderma lucidum, they grow in various humid locations in Asia.

Reishi mushrooms are thought to work in a few different ways to ease anxiety.

First, Reishi is thought to help reduce inflammation in the body. Chronic inflammation has been linked to anxiety and depression. By reducing inflammation, Reishi may help to reduce anxiety symptoms.

Reishi is also thought to boost levels of GABA in the brain. GABA is a neurotransmitter that helps to regulate anxiety. Low levels of GABA have been linked to anxiety and panic disorders. By boosting GABA levels, Reishi may help to reduce anxiety symptoms.

Reishi is also thought to have antioxidant and adaptogenic properties. Adaptogens are substances that help the body adapt to stress, while antioxidants help to protect the body from the damaging effects of free radicals.

Free radicals are unstable molecules that can damage cells and lead to inflammation. By reducing free radical damage and helping the body adapt to stress, Reishi may help to reduce anxiety symptoms.

Powerful mood stabilizer
  • Improve negative thought patterns for greater emotional balance

  • Decrease social anxiety without side effects

  • Increase verbal fluency and clarity of thoughts

  • Promote better sleep

N-acetylcysteine (NAC) is a compound that has a wide range of potential health benefits. It is an amino acid (a building block of protein) that helps to make glutathione, one of the body’s most important antioxidants. NAC has been shown to have positive effects on mental health, cognitive function , and anxiety.14Olivia Dean, BSc, PhD, Frank Giorlando, MBBS, BMedSc, and Michael Berk, MBBCh, MMed(Psych), PhD, N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action, J Psychiatry Neurosci. 2011

NAC supplements have a range of potential benefits for anxiety, including: reducing anxiety symptoms, improving communication in relationships, and reducing stress levels.

NAC may also help to reduce the severity of anxiety disorders such as panic disorder and social anxiety disorder (OCD, GAD, and others).15Olivia Dean, BSc, PhD, Frank Giorlando, MBBS, BMedSc, and Michael Berk, MBBCh, MMed(Psych), PhD, N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action, J Psychiatry Neurosci. 2011.

The exact mechanism of action of NAC is not fully understood, but it is thought to work by increasing levels of glutathione and inhibiting the release of the neurotransmitter glutamate.

The Mushroom for Energy

Cordyceps Mushroom Powder by Freshcap

  • Enhance oxygen capacity and ATP

  • Improve blood flow when stressed or anxious

  • Increase mental health and wellness with antioxidant properties

  • Contains high amounts of zinc (essential for cells, immune system, wound healing)


  • Available in capsules and powder form
  • Can protect against health problems like asthma, depression, diabetes, fatigue, high cholesterol, and upper respiratory tract infections.
  • Has been shown to improve athletic performance and reduce fatigue.
  • All-natural


  • Quality cordyceps can be quite expensive and hard to find

The benefits of Cordyceps have been linked with enhanced oxygen capacity and adenosine triphosphate (ATP) energy production in cells, which means that this therapeutic mushroom will help your body utilize oxygen more efficiently and enhance blood flow when stressed or anxious.16Syed Amir Ashraf, Abd Elmoneim. Elkhalifa, Arif Jamal Siddiqui, Mitesh Patel, Amir Mahgoub Awadelkareem, Mejdi Snoussi, Mohammad Saquib Ashraf, Mohd Adnan, and Sibte Hadi, Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus Cordyceps with Its Nutraceutical and Therapeutic Potential, Molecules. 2020

Hence, it is recommended to increase intake of this fungus on a regular basis to overcome anxiety, stress and support your mental health and wellness.

Cordycepin has also been shown to have antidepressant and anti-anxiety effects in animal-based research models.17Hardeep S. Tuli, Sardul S. Sandhu, and A. K. Sharma, Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin, 3 Biotech. 2014

Multiple literature suggests that cordyceps acts like an adaptogen, which means it will help you to increase your body’s resistance to anxiety, fatigue, stress, and trauma.18Jingjing Song, Yingwu Wang, Meiyu Teng, Guangsheng Cai, Hongkai Xu, Hanxiao Guo, Yang Liu, Di Wang, * and Lesheng Teng , Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model, Evid Based Complement Alternat Med. 2015

Freshcap Mushrooms provide the highest percentage of beta glucans and fruiting body nutrients, making this mushroom product my preferred choice for Cordyceps.

Most Powerful Stress Resistance Herb

Ashwagandha by Nootropics Depot

Ashwagandha by Nootropics Depot
Check PriceGet 5% off entire order w/ code HOLISTICNOOTROPICS
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  • Improved cognitive function

  • Increased energy levels

  • Enhanced stress resistance

  • Modulates neurotransmitter activity


  • Has been shown to help improve memory and cognitive function
  • Helps reduce anxiety and stress levels, as well as improve sleep quality
  • Strong anti-inflammatory agent, making it helpful for conditions like arthritis and asthma
  • Can help reduce blood sugar levels
  • Studies show taking ashwagandha can reduce cholesterol levels, helping to reduce high cholesterol levels
  • Can be taken daily


  • Should be avoided by pregnant women and those who are breastfeeding
  • Can interfere with diabetes medicines
  • Should be avoided by those with thyroid disorders
  • May cause some stomach upset such as diarrhea and vomiting

The main active ingredient in ashwagandha is withanolide. Withanolide is a steroidal lactone that has been shown to have numerous medicinal properties. Ashwagandha also contains other compounds such as alkaloids, tannins, and saponins. These compounds all work together to provide the herb’s many health benefits, including reducing inflammation, improving brain function, and even helping to fight cancer.19K Chandrasekhar , Jyoti Kapoor, Sridhar Anishetty,A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults, Indian J Psychol Med. 2012

However, anxiety is one of the most common reasons people take Ashwagandha supplements. This is likely due to the fact that ashwagandha can help to regulate cortisol levels. Cortisol is a stress hormone that can have negative effects on the body if it becomes imbalanced.

Another way that ashwagandha supplements may work is by improving cognitive function. This is likely due to the fact that the herb can help to improve blood circulation and increase oxygen levels in the brain. Additionally, ashwagandha has been shown to promote nerve growth and protect neurons from damage.

If you do decide to take ashwagandha supplements, it’s important to choose a high-quality product. This is because the quality of ashwagandha supplements can vary greatly. Look for a product that is made from organic, wild-harvested ashwagandha and that contains no fillers or additives.

When it comes to dosage, it’s best to start with a lower dose and increase gradually as needed. Ashwagandha supplements are typically taken in capsule form, but they can also be taken in powder form. The powder can be added to water or juice and consumed once or twice daily.

Holistic Ways to Improve Anxiety

When anxiety becomes a daily struggle, even before turning to medications, there are many things you can do on your own to feel better. For example, you can try one of these holistic, drug-free remedies, from mind-body techniques to calming teas.

Gut Health

Looking after the microbes living in your gut can be a great way to keep anxiety symptoms at bay. You can do so using probiotics and/or digestive enzymes.

Probiotics – for example, Lactobacillus helveticus and Bifidobacterium longum have both been found to be good probiotics for anxiety and overall brain health.1Michaël Messaoudi,Nicolas Violle,Jean-François Bisson,Didier Desor,Hervé Javelot &Catherine Rougeot, Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers Gut Microbes. 20112Michaël Messaoudi, Robert Lalonde,Nicolas Violle, Hervé Javelot,Didier Desor,Amine Nejdi,Jean-François Bisson,Catherine Rougeot,Matthieu Pichelin,Murielle Cazaubiel,Jean-Marc CazaubielAssessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects Cambridge University Press. 2010

You can try MegaSporeBiotic from Microbiome Labs as a complete probiotics supplement.

#1 Recommended Probiotic amongst functional practitioners

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  • Spore-encapsulated probiotics ensure strains colonize your gut.

  • Contains 5 strains of beneficial bacteria clinically proven to boost overall gut function

  • Great for anyone who deals with digestive disorders

  • Does not need refrigeration.

  • Shelf life is much longer than most other probiotics.

Digestive Enzymes – life is better when digestion works at its best. For example, a digestive enzyme supplementation, lactase if you are lactose intolerant, improves anxiety3J Yang , M Fox, Y Cong, H Chu, X Zheng, Y Long, M Fried, N Dai, Lactose intolerance in irritable bowel syndrome patients with diarrhoea: the roles of anxiety, activation of the innate mucosal immune system and visceral sensitivity Aliment Pharmacol Ther. 2014.

Bioidentical Digestive Enzymes


Shop NowUse code holisticnootropics10 to save 10%
Shop NowUse code holisticnootropics10 to save 10%
  • Potent blend of 14+ natural enzymes to support protein, carbohydrate, and fat digestion

  • Improves nutrient absorption

  • Relieves occasional gas, bloating, and indigestion

  • USA: Free Shipping Over $90 CAN: Free Shipping Over $150 International: Free Shipping Over $200

  • Promotes a balanced microbiome for overall wellness and decreased inflammation

  • Vegetarian, gluten-free, and dairy-free formula


  • High quality digestive enzyme that helps with protein, fat, carbohydrate digestion
  • Free shipping available in the US, Canada, and Internationally
  • Endorsed by the biggest names in health and wellness
  • Many discounts available


  • Some people may experience digestive side effects

Our Favorite Wearable for ADHD and Anxiety

Apollo Wearable by Apollo Neuro

Apollo Wearable by Apollo Neuro
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Shop NowBlack Friday! Up to $70 Off With Our Links – No Discount Code Needed
  • Drug-free stress relief and HRV Improvement

  • Portable and discreet

  • Backed by clinical research

  • Syncs with mobile app

  • One year warranty


  • Apollo Wearable Device is clinically and anecdotally proven to raise HRV – an important sign of stress relief
  • Easy to use. No assembly required. No extra cords or wires are necessary
  • Benefits include sleep enhancement, focus boosts, mood improvements, stress relief
  • Intuitive smartphone app interface that includes 7 settings
  • Exclusive 10% Apollo Neuro discount through links on this page


  • Battery life allows only 4-6 uses
  • Some users do not experience immediate results.

Red Light/Infrared Light Therapy – a simple, all-natural modality that harnesses photobiomodulation to increase energy level and fight anxiety and depression4Michael R Hamblin, Shining light on the head: Photobiomodulation for brain disorders BBA Clin. 2016.

Red Light Therapy For Mental Health
#1 Red Light Sauna


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  • High quality full-spectrum infrared saunas

  • Customizable sauna sizes and finishes

  • Optional near, mid & far infrared heatmap settings

  • 100-day money-back guarantee

  • EMF-Free

  • Handcrafted in the USA


  • SaunaSpace is very easy to use. Smaller models are ready out of the box.
  • SaunaSpace Photon is very portable. It is small enough to fit in a suitcase, so you can take it with you when you travel.
  • SaunaSpace Photon produces very little heat. This means that you can use it for a more extended period of time without feeling uncomfortable.
  • Many models and levels to choose from. Single bulb photon light all the way up to Luminati Infrared Sauna
  • EMF-Free!
  • Sauna Space full-spectrum incandescent bulbs give more infrared health benefits than LCD bulbs of other red light devices.


  • Saunas are a major investment
  • Lead times can be 6-8 weeks

Improve your diet

Start with avoiding toxic foods that trigger anxiety. Eat more protein and good quality fats (e.g., red meat, organ meats, choline-rich foods, Omega 3 Rich Foods)

Avoid Sugar and Maintain Healthy Metabolic Health

Poor metabolic health is as much to blame for anxiety and declining mental health as any lifestyle habit. This is why it’s important to use tools that can help you identify foods that spike blood sugar and reduce metabolic flexibility. Below I highlight the Nutrisense Continuous Glucose Monitor and the Lumen Metabolic Checker, 2 great tools for keeping your metabolism and subsequent anxiety at bay.

The hand-held metabolism checker

Lumen Metabolism Tracker

Lumen Metabolism Tracker
Get LumenSave $25 w. code: HN25
Get LumenSave $25 w. code: HN25
  • GET REAL-TIME DATA ON YOUR METABOLISM – The Lumen is a hand-held metabolism checker that gives you accurate data on how food and activity affects your metabolism.

  • – USE IT FIRST THING IN THE MORNING – The Lumen is perfect for anyone looking to lose weight and optimize their health. Use it first thing in the morning, before and after meals, before and after workouts, or really any time you want to know how food or activity affects your metabolism.

  • Follow the link and use the code “Nootropics” to save an additional $50 off the purchase of a Lumen with our exclusive partner deal!

  • SIMPLE TO USE – The Lumen is a small, portable breathing device that fits in the palm of your hand. There’s only one button to turn it on and off while the smartphone app guides you through the breathing sequence.

Track your glucose in real time


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Get StartedSave $25 at Checkout w. code: NOOTROPICS25
  • The most advanced method for keeping track of blood glucose

  • Identify specific foods, beverages, and activities that impact blood glucose

  • Easy to use. Easy to apply. Easy to get.

  • All users work with a Nutrisense dietician to best optimize experience

  • Can be worn while sleeping, in the shower, and during most regular daily activities


Exercise is a powerful anxiety fighter for many reasons.

It leads to changes in the brain that promote feelings of calm and wellbeing5Brendon Stubbs , Davy Vancampfort , Simon Rosenbaum , Joseph Firth , Theodore Cosco , Nicola Veronese , Giovanni A Salum , Felipe B Schuch , An examination of the anxiolytic effects of exercise for people with anxiety and stress-related disorders: A meta-analysis Psychiatry Res. 2017.

Good examples of exercise for anxiety include yoga and strength training.

Both release endorphins, chemicals in your brain that energize your mood and make you feel good (20).

Exercise also doubles as a distraction, allowing you to find some peaceful time to break out of the cycle of negative thoughts that feed anxiety6Aaron Kandola , Brendon Stubbs, Exercise and Anxiety Adv Exp Med Biol. 2020.

exercise anxiety

Breathing exercises

Examples of breathing exercises include meditation, alternate nostril breathing, and EFT tapping.

Several clinical studies have shown how mindfulness meditation, for example, is a promising therapeutic strategy for anxiety and can significantly improve stress reactivity7Sy Atezaz Saeed, Karlene Cunningham, Richard M Bloch, Depression and Anxiety Disorders: Benefits of Exercise, Yoga, and Meditation Am Fam Physician. 2019.

yoga breathing exercise for anxiety

Calming Teas

Chamomille is one of the most commonly used calming tea. For example, more than 150 participants in a clinical study reported that long-term use of chamomille reduced generalized anxiety disorder8Jun J.MaoaSharon X.XiebJohn R.KeefecIreneSoellerdQing S.LidJay D.Amsterdam, Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial Phytomedicine. 2016.

Tulsi, also called Holy Basil, is an Indian medical plant shown to decrease anxiety symptoms in several clinical and preclinical studies9D Bhattacharyya , T K Sur, U Jana, P K Debnath, Controlled programmed trial of Ocimum sanctum leaf on generalized anxiety disorders Nepal Med Coll J. 200810Manavi Chatterjee , Pinki Verma, Rakesh Maurya, Gautam Palit, Evaluation of ethanol leaf extract of Ocimum sanctum in experimental models of anxiety and depression Pharm Biol. 2011.

Hibiscus is another calming tea with significant anxiolytic effects11Cláudia Vanzella, Paula Bianchetti, Sabrina Sbaraini, Samanta Inês Vanzin, Maria Inês Soares Melecchi, Elina Bastos Caramão, and Ionara Rodrigues Siqueira, Antidepressant-like effects of methanol extract of Hibiscus tiliaceus flowers in mice BMC Complement Altern Med. 2012.

Hibiscus tea anxiety

What Is Anxiety?

Anxiety can affect you both mentally and physically and can present itself with a variety of symptoms. Common symptoms include:

  • Feeling nervous, agitated, and angry
  • Feeling powerless
  • Having a sense of unexplained impending danger, panic, or doom
  • Having an increased heart rate (tachycardia)
  • Breathing rapidly (hyperventilation)
  • Sweating
  • Trembling
  • Feeling weak or tired
  • Struggling to pay attention and focus
  • Sleep disturbances

HPA Axis and Stress Response

Physiologically, the hypothalamic-pituitary-adrenal (HPA) axis mediates the stress response.12Mary Ann C. Stephens, Ph.D.,Gary Wand, M.D. Stress and the HPA Axis Role of Glucocorticoids in Alcohol Dependence Alcohol Res. 2012

Anxiety is characterized by a dysregulation of the HPA axis13Gustavo E. Tafet1 and Charles B. Nemeroff Pharmacological Treatment of Anxiety Disorders: The Role of the HPA Axis Front. Psychiatry. 2020.

Anxiety disorders are often found as a comorbidity with depression14Zhiguo WU and Yiru FANG, Comorbidity of depressive and anxiety disorders: challenges in diagnosis and assessment Shanghai Arch Psychiatry. 2014.

Both anxiety and depression are strictly connected to gut health.

70% of dopamine and 90% of serotonin are produced in the gut15Philip Strandwitz, Neurotransmitter modulation by the gut microbiota Brain Res. 2019.

Dopamine and serotonin are both neurotransmitters and are both considered “happy neurochemicals.” They are related to mood and happiness.

Dopamine and serotonin also play crucial roles in sleep, digestion, pain response, and other bodily functions.

This means that what is going on in your gut will affect your mood, anxiety, depression, and focus16Dr. Siri Carpenter, That gut feeling American Psychological Association. 2012.

Types of Anxiety

There are several different types of anxiety. Let’s look at the five most common ones.

Generalized Anxiety Disorder (GAD)

Delta 8 THC

A long-term condition that causes feelings of anxiety and exaggerated worry. These worries regard a wide range of issues and situations rather than one specific event17Rowa, Karen Antony, Martin M., Generalized anxiety disorder. American Psychological Association. 2008.

Obsessive-Compulsive Disorder (OCD)

An anxiety disorder characterized by having repetitive thoughts, behaviors, and urges18Daniel A Drubach, Obsessive-compulsive disorder Continuum (Minneap Minn). 2015.

Panic Disorder

An anxiety disorder where unexpected and intense fear is accompanied by severe physical manifestations such as chest pain, sweat, and palpitations19Peter P Roy-Byrne , Michelle G Craske, Murray B Stein, Panic disorder Lancet. 2006.

Post-Traumatic Stress Disorder (PTSD)


An anxiety disorder that develops after exposure to a traumatic event20Heather A Kirkpatrick, Grant M Heller, Post-traumatic stress disorder: theory and treatment update Int J Psychiatry Med. 2014.

Social Anxiety Disorder

Phenibut is a powerful anti-anxiety medication, but it does have the potential for abuse

A condition where the subject experiences overwhelming worry and self-consciousness about social situations.21Falk Leichsenring, Frank Leweke, Social Anxiety Disorder N Engl J Med. 2017

Common Anxiety Prescriptions Medications


Treatment for anxiety usually consists of psychotherapy and medications. The most common prescription medications for anxiety include:

  • Benzodiazepines
  • Antidepressants


A group of sedatives commonly used to treat anxiety disorder22Malcolm Lader, Benzodiazepines revisited–will we ever learn? Addiction. 2011.

They work by enhancing the neurotransmitter GABA activity, a chemical in the brain that helps the feeling of calmness.

They also help with sleep disturbances.

Some common benzo’s include:

  • Xanax
  • Klonopin
  • Valium
  • Ativan
  • Tranxene


Antidepressants are also used to treat anxiety, particularly Selective Serotonin Reuptake Inhibitors (SSRIs).

They work by increasing the levels of the neurotransmitter serotonin.

This chemical affects mood, sleep, memory, sexual desire, and appetite23M Berk, Selective serotonin reuptake inhibitors in mixed anxiety-depression Int Clin Psychopharmacol. 2000.

In comparison to benzodiazepines, they have less risk of developing dependence.

Therefore, they are a good option for chronic anxiety.

However, they take up to 4-5 weeks to begin relieving the symptoms, so they cannot be taken at need24M Berk, Selective serotonin reuptake inhibitors in mixed anxiety-depression Int Clin Psychopharmacol. 2000.


Some common SSRI’s include:

  • Cymbalata
  • Effexor
  • Pristiq

Things That Make Anxiety Worse


The Best Nootropics for Anxiety


Do any of the nootropics we listed work well for you? Have you had success with a different supplement or medication? Let us know in the comments below. We’d love to hear about your experiences and whether our recommendations worked for you.


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Erik Abramowitz is a certified Nutritional Therapy Practitioner (NTP), Naturopathic Doctoral student, health coach, and father. He is the primary content creator for HolisticNootropics.com and the host of the Holistic Nootropics Podcast.

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