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MegaSporeBiotic Review- This Is The Best Probiotic

Medically reviewed by Dr. Darshan Shingala MD, MPH — Written by Erik Levi, FNTP — Updated on July 10, 2021

OVERVIEW:

  • Megasporebiotic is a spore-based probiotic that includes multiple bacillus strains.

  • The spore-based design helps the probiotics survive your stomach acid and more effectively populate the digestive tract.

  • Megasporebiotic has been clinically proven to lower incidences of gut infections and associated gut problems.

  • Does not need to be refrigerated.

  • Megaspore is only available directly through practitioners.  Use links below to sign up for a qualified account.

#1 Recommended Probiotic

Product Name: Megasporebiotic

Product Description: Megasporebiotic is a powerful, spore-based probiotic that is scientifically proven to successfully populate your digestive tract with beneficial bacteria. Megaspore contains strains of probiotics that are clinically proven to boost digestion and nutrient absorption, and help you recover from gut disorders.

Availability: InStock

  • Effectiveness
  • Product longevity (Shelf-Stable)
  • Health Benefits
  • Easy To Use
  • Cost
Overall
4.9

Pros

#1 Recommended Probiotic amongst functional practitioners.

Spore-encapsulated probiotics ensure strains colonize your gut.

Contains 5 strains of beneficial bacteria clinically proven to boost overall gut function

Great for anyone who deals with digestive disorders

Does not need refrigeration.

Shelf life is much longer than most other probiotics.

Cons

The formula is very powerful and using too much, too fast can lead to digestive distress.

Only available through practitioners.

If you’re interested in cognitive enhancement, boosting your gut health should be your number one priority.

One of the top ways to boost gut health is with a high-quality probiotic.

Unfortunately, most of the $50 Billion probiotic industry is overhyped junk that doesn’t even survive your stomach acid to populate your GI tract.

probiotics

The good news is that there is a new generation of spore-based probiotics that are clinically proven to survive your stomach acid and successfully colonize your gut.

For you, that means improved physical health, a stronger immune system, and thanks to the gut/brain connection- a sharper mind.

The following review is all about my number one probiotic recommendation, Megasporebiotic, a spore-based probiotic that actually works!

What Is Megasporebiotic

Megasporebiotic is an entirely spore-based, wide-spectrum probiotic which has clinically demonstrated the maintenance of healthy and balanced gut function.1Microbiomelabs, MegaSporeBiotic™, Microbiomelabs2MINDY WEISMAN, MegaSporeBiotic by Microbiome Labs Review, lifesparknutrition. 2020

Megasporebiotic consists of a combination of several Bacillus organisms such as B. cereus, B. clausii, B. coagulans, B. licheniformis, B. polyfermenticus, B. pumilus, and B. subtilis.3Brian K McFarlin, Andrea L Henning, Erin M Bowman, Melody A Gary, and Kimberly M CarbajalOral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers, World J Gastrointest Pathophysiol. 20174Na-Kyoung Lee, Won-Suck Kim, Hyun-Dong Paik,Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier, Food Sci Biotechnol. 2019

  • Spore-Based Probiotic 
  • Survives Stomach Acid
  • Fights Gut Infections
  • Full Gut Healing
  • Less Inflammation
  • Sharper Mind

Mega

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What Is Megasporebiotic Used for?

Megasporebiotic is an exclusive all-spore formula that can effectively promote gut microflora’s biodiversity and substantially recondition the gut microbiome.5Microbiomelabs, MegaSporeBiotic™, Microbiomelabs6MINDY WEISMAN, MegaSporeBiotic by Microbiome Labs Review, lifesparknutrition. 2020

Bacillus probiotic

The Bacillus probiotic strains in Megasporebiotic have clinically shown to possess many beneficial properties that promote overall gut health; for instance, they have antimicrobial, anticarcinogenic, and antioxidant characteristics. 7Microbiomelabs, MegaSporeBiotic™, Microbiomelabs8MINDY WEISMAN, MegaSporeBiotic by Microbiome Labs Review, lifesparknutrition. 20209Na-Kyoung Lee, Won-Suck Kim , Hyun-Dong Paik , Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier, Food Sci Biotechnol. 2019

Spore Based Probiotics Are Better Than Traditional Probiotics?

Spore-based probiotics are microbial balancers derived from the dormant spores of soil-based microorganisms.10designsforhealth, Dig up the dirt on spore-based probiotics, designsforhealth. 2019

Compared to traditional probiotics, spore-based probiotics are highly stable in adverse environments, such as the stomach’s harsh acidic environment.

spore-based probiotics

Thus, spore-based probiotics are more effective than conventional probiotics at colonizing the gut microflora and delivering added benefits.11Microbiomelabs, MegaSporeBiotic™, Microbiomelabs12MINDY WEISMAN, MegaSporeBiotic by Microbiome Labs Review, lifesparknutrition. 202013designsforhealth, Dig up the dirt on spore-based probiotics, designsforhealth. 2019

No Refrigeration

Megasporebiotic has a long shelf-life of over five years and does not require refrigeration.14Microbiomelabs, MegaSporeBiotic™, Microbiomelabs15MINDY WEISMAN, MegaSporeBiotic by Microbiome Labs Review, lifesparknutrition. 2020

Megaspore and Mental Health

It is scientifically proven that many neurotransmitters are synthesized in the gut and communicate to the brain’s neuroreceptors via the bloodstream, establishing a gut-brain axis.

BiOptimizers' Masszymes Review - Digestive Enzyme Supplement That Works!

Thus, a healthy gut can promote healthy brain function and improved mental health by alleviating depressive symptoms.16Caroline J. K. Wallace and Roumen Milev, The effects of probiotics on depressive symptoms in humans: a systematic review, Ann Gen Psychiatry. 201717Xiaofei Liu, Shangqing Cao, Xuewu Zhang , Modulation of Gut Microbiota-Brain Axis by Probiotics, Prebiotics, and Diet, J Agric Food Chem. 2015 18Emeran A Mayer, Kirsten Tillisch, Arpana Gupta, Gut/brain axis and the microbiota, J Clin Invest. 201519Namhee Kim, Misun Yun, Young Joon Oh, Hak-Jong Choi, Mind-altering with the gut: Modulation of the gut-brain axis with probiotics, J Microbiol
. 2018
20Deepak K Rajpal, James R Brown, Modulating the human gut microbiome as an emerging therapeutic paradigm, Sci Prog. 2013 21Katie Louise Tooley, Effects of the Human Gut Microbiota on Cognitive Performance, Brain Structure and Function: A Narrative Review, Nutrients. 2020 22Cory I Wasser, Emily-Clare Mercieca, Geraldine Kong, Anthony J Hannan, Sonja J McKeown, Yifat Glikmann-Johnston, Julie C Stout, Gut dysbiosis in Huntington’s disease: associations among gut microbiota, cognitive performance and clinical outcomes, Brain Commun. 2020 23Brian K McFarlin, Andrea L Henning, Erin M Bowman, Melody A Gary, and Kimberly M Carbajal, Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers, World J Gastrointest Pathophysiol. 201724Yuanpeng Zheng, Tessa A. Verhoeff,Paula Perez Pardo, Johan Garssen, and Aletta D. Kraneveld, The Gut-Brain Axis in Autism Spectrum Disorder: A Focus on the Metalloproteases ADAM10 and ADAM17, Int J Mol Sci. 2021

Megaspore and Inflammation

The evidence shows us that Megasporebiotic has antimicrobial, anti-inflammatory, and immunomodulating properties.

In a clinical study, the participants receiving Megasporebiotic reported a significant reduction of inflammation after 30 days of usage.25Brian K McFarlin, Andrea L Henning, Erin M Bowman, Melody A Gary, and Kimberly M Carbajal, Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers, World J Gastrointest Pathophysiol. 2017

Megasporebiotic’s Amazing Gut Health Benefits

Megasporebiotic’s bioavailable probiotics have proven time and again to promote many gut health benefits.

Below are some examples of GI conditions that Megaspore has been proven to alleviate.

Leaky Gut/Intestinal Permeability

Studies suggest that consuming an oral spore-based probiotic supplement may significantly improve the symptoms of increased intestinal permeability, also known as “leaky gut” syndrome. 26Brian K McFarlin, Andrea L Henning, Erin M Bowman, Melody A Gary, and Kimberly M Carbajal, Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers, World J Gastrointest Pathophysiol. 201727Caroline Reiff , Denise Kelly, Inflammatory bowel disease, gut bacteria and probiotic therapy, Int J Med Microbiol. 201028Magdy El-Salhy, Nutritional Management of Gastrointestinal Diseases and Disorders, Nutrients. 201929Heidi M Staudacher, Kevin Whelan, Altered gastrointestinal microbiota in irritable bowel syndrome and its modification by diet: probiotics, prebiotics and the low FODMAP diet, Proc Nutr Soc. 2016 30P C Konturek, Yurdagül Zopf[Therapeutic modulation of intestinal microbiota in irritable bowel syndrome. From probiotics to fecal microbiota therapy], MMW Fortschr Med. 201731Heidi Maria Staudacher, Miranda C E Lomer, Freda M Farquharson, Petra Louis, Francesca Fava , Elena Franciosi, Matthias Scholz, Kieran M Tuohy, James O Lindsay, Peter M Irving, Kevin WhelanA Diet Low in FODMAPs Reduces Symptoms in Patients With Irritable Bowel Syndrome and A Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial, Gastroenterology. 201732Brooks D Cash, Emerging role of probiotics and antimicrobials in the management of irritable bowel syndrome, Curr Med Res Opin. 201433Wei Chung Chen, Eamonn M M Quigley, Probiotics, prebiotics & synbiotics in small intestinal bacterial overgrowth: opening up a new therapeutic horizon!, Indian J Med Res. 2014 34Angélica T Vieira, Mauro M Teixeira, Flaviano S Martins, The role of probiotics and prebiotics in inducing gut immunity, Front Immunol. 2013 35Brian K McFarlin, Andrea L Henning, Erin M Bowman, Melody A Gary, and Kimberly M Carbajal , Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers, World J Gastrointest Pathophysiol. 2017

Leaky Gut

Leaky gut syndrome is an inflammatory digestive condition in which bacterial toxins and metabolic by-products “leak” through the gut barrier due to increased endothelial wall permeability.

It is well-known that probiotic strains effectively inhibit the inflammatory cascade, help the process of food breakdown, and strengthen the mucosal barrier, thereby reducing the symptoms of the leaky gut syndrome.

Irritable Bowel Syndrome-IBS

Irritable Bowel Syndrome

Megasporebiotic effectively stimulates healthy intestinal microbes, helps the absorption of nutrition, and preserves overall immune homeostasis, thereby impeding the risk of the digestive tract’s inflammatory disorders such as inflammatory bowel disease.36Adrian Catinean, Adriana Maria Neag , Andreea Nita , Mihaela Buzea , Anca Dana Buzoianu, Bacillus spp. Spores-A Promising Treatment Option for Patients with Irritable Bowel Syndrome, Nutrients. 201937Taylor C Judkins, Douglas L Archer, Dean C Kramer, Rebecca J Solch, Probiotics, Nutrition, and the Small Intestine, Curr Gastroenterol Rep. 2020 38Caroline Reiff , Denise Kelly, Inflammatory bowel disease, gut bacteria and probiotic therapy, Int J Med Microbiol. 2010 39Magdy El-Salhy, Nutritional Management of Gastrointestinal Diseases and Disorders, Nutrients. 201940Heidi M Staudacher, Kevin Whelan , Altered gastrointestinal microbiota in irritable bowel syndrome and its modification by diet: probiotics, prebiotics and the low FODMAP diet, Proc Nutr Soc. 201641P C Konturek , Yurdagül Zopf, Therapeutic modulation of intestinal microbiota in irritable bowel syndrome. From probiotics to fecal microbiota therapy, MMW Fortschr Med. 201742Heidi Maria Staudacher , Miranda C E Lomer, Freda M Farquharson , Petra Louis , Francesca Fava , Elena Franciosi , Matthias Scholz , Kieran M Tuohy , James O Lindsay , Peter M Irving , Kevin Whelan, A Diet Low in FODMAPs Reduces Symptoms in Patients With Irritable Bowel Syndrome and A Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial, Gastroenterology. 201743Brooks D CashEmerging role of probiotics and antimicrobials in the management of irritable bowel syndrome, Curr Med Res Opin. 201444Adrian Catinean, Maria Adriana Neag , Kiran Krishnan , Dana Maria Muntean , Corina Ioana Bocsan , Raluca Maria Pop, Andrei Otto Mitre , Carmen Stanca Melincovici , Anca Dana Buzoianu, Probiotic Bacillus Spores Together with Amino Acids and Immunoglobulins Exert Protective Effects on a Rat Model of Ulcerative Colitis, Nutrients. 202045Maurizio Gabrielli, Ernesto Cristiano Lauritano, Emidio Scarpellini, Andrea Lupascu, Veronica Ojetti, Giovanni Gasbarrini, Nicolò Gentiloni Silveri, Antonio Gasbarrini, Bacillus clausii as a treatment of small intestinal bacterial overgrowth, Am J Gastroenterol. 200946Wei Chung Chen, Eamonn M M Quigley, Probiotics, prebiotics & synbiotics in small intestinal bacterial overgrowth: opening up a new therapeutic horizon, Indian J Med Res. 201447Angélica T Vieira , Mauro M Teixeira , Flaviano S Martins, The role of probiotics and prebiotics in inducing gut immunity, Front Immunol. 201348Adrian Catinean, Maria Adriana Neag, Kiran Krishnan, Dana Maria Muntean, Corina Ioana Bocsan, Raluca Maria Pop, Andrei Otto Mitre, Carmen Stanca Melincovici, and Anca Dana Buzoianu, Probiotic Bacillus Spores Together with Amino Acids and Immunoglobulins Exert Protective Effects on a Rat Model of Ulcerative Colitis, Nutrients. 202049Mohammad Z. Asha1,and Sundos F. H. Khalil, Efficacy and Safety of Probiotics, Prebiotics and Synbiotics in the Treatment of Irritable Bowel Syndrome, Sultan Qaboos Univ Med J. 2020

Small Intestine Bacterial Overgrowth – SIBO

Spore-based probiotics, especially those containing B. clausii, are a suitable adjunct to the treatment of Small Intestinal Bacterial Overgrowth (SIBO) as they are well-tolerated by most people and they help to reduce the recurrence rate after decontamination.

Small Intestine Bacterial Overgrowth

As an added benefit, spore-based probiotics used in the management of SIBO can reduce the patient’s dependency on antibiotics, thus limiting the risk of antibiotic resistance and adverse side effects.50Adrian Catinean, Maria Adriana Neag , Kiran Krishnan , Dana Maria Muntean , Corina Ioana Bocsan , Raluca Maria Pop, Andrei Otto Mitre , Carmen Stanca Melincovici , Anca Dana Buzoianu, Probiotic Bacillus Spores Together with Amino Acids and Immunoglobulins Exert Protective Effects on a Rat Model of Ulcerative Colitis, Nutrients. 202051Maurizio Gabrielli, Ernesto Cristiano Lauritano, Emidio Scarpellini, Andrea Lupascu, Veronica Ojetti, Giovanni Gasbarrini, Nicolò Gentiloni Silveri, Antonio Gasbarrini, Bacillus clausii as a treatment of small intestinal bacterial overgrowth, Am J Gastroenterol. 200952Wei Chung Chen, Eamonn M M Quigley, Probiotics, prebiotics & synbiotics in small intestinal bacterial overgrowth: opening up a new therapeutic horizon, Indian J Med Res. 201453Angélica T Vieira , Mauro M Teixeira , Flaviano S Martins, The role of probiotics and prebiotics in inducing gut immunity, Front Immunol. 201354Shaniko Shini, R. Claire Aland, and Wayne L. Bryden, Avian intestinal ultrastructure changes provide insight into the pathogenesis of enteric diseases and probiotic mode of action, Sci Rep. 2021

Full Body Health Benefits of Megaspore

Megaspore’s ability to recondition the gut, heal infections, and boost overall GI function is certainly impressive.

In addition to optimizing the gut-brain connection, it can improve many crucial parts of your full body health as well.

Immunity

Megasporebiotic works as an immune booster by inducing protective responses to pathogens and maintaining healthy regulatory pathways in the human body.

immunity

The improved immune response lowers the body’s inflammatory status by stabilizing homeostasis and improving clinical outcomes in patients with chronic conditions such as diabetes, hypertension, and autoimmune diseases.

In general, a healthy microbiome is a prerequisite to a healthy immune system because of its symbiotic dependence.55Angélica T Vieira, Mauro M Teixeira, Flaviano S Martins, The role of probiotics and prebiotics in inducing gut immunity, Front Immunol. 201356Yasmine Belkaid and Timothy Hand, Role of the Microbiota in Immunity and inflammation, Cell. Author manuscript. 201557Rafael Corrêa, Igor de Oliveira Santos, Heloísa Antoniella Braz-de-Melo, Lívia Pimentel de Sant’Ana, Raquel das Neves Almeida, Gabriel Pasquarelli-do-Nascimento, Paulo Sousa Prado, Gary P. Kobinger, Corinne F. Maurice, and Kelly Grace Magalhães, Gut microbiota modulation induced by Zika virus infection in immunocompetent mice, Sci Rep. 202158Chang Hun Lee, Yunjung Choi, Seung Young Seo, Seong-Hun Kim, In Hee Kim, Sang Wook Kim, Soo Teik Lee, and Seung Ok Lee, Addition of probiotics to antibiotics improves the clinical course of pneumonia in young people without comorbidities: a randomized controlled trial, Sci Rep. 202159Luigi Santacroce, Francesco Inchingolo, Skender Topi, Raffaele Del Prete, Michele Di Cosola, Ioannis Alexandros Charitos, and Monica Montagnani, Potential beneficial role of probiotics on the outcome of COVID-19 patients: An evolving perspective, Diabetes Metab Syndr. 202160Yuanpeng Zheng, Tessa A. Verhoeff, Paula Perez Pardo, Johan Garssen, and Aletta D. Kraneveld, The Gut-Brain Axis in Autism Spectrum Disorder: A Focus on the Metalloproteases ADAM10 and ADAM17, Int J Mol Sci. 2021

Triglycerides

Research suggests that a probiotic supplement with at least five different spore-forming bacterias can effectively lower moderately elevated triglyceride levels.61Andrew W Campbell , Drew Sinatra , Zhiwei Zhang , Stephen T Sinatra, Efficacy of Spore Forming Bacilli Supplementation in Patients with Mild to Moderate Elevation of Triglycerides: A 12 week, Randomized, Double-Blind, Placebo Controlled Trial, Integr Med (Encinitas). 202062Brian K McFarlin , Andrea L Henning, Erin M Bowman , Melody A Gary , Kimberly M Carbajal, Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers, World J Gastrointest Pathophysiol. 201763H Y Ahn , M Kim , Y-T Ahn , J-H Sim 3, I-D Choi , S-H Lee , J H Lee, The triglyceride-lowering effect of supplementation with dual probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032: Reduction of fasting plasma lysophosphatidylcholines in nondiabetic and hypertriglyceridemic subjects, Nutr Metab Cardiovasc Dis. 201564Na-Kyoung Lee , Won-Suck Kim , Hyun-Dong Paik , Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier, Food Sci Biotechnol. 2019

triglycerides

In a clinical study, participants who received Megasporebiotic showed a significant decrease of 24% in their triglyceride levels in 30 days.65Brian K McFarlin, Andrea L Henning, Erin M Bowman, Melody A Gary, and Kimberly M Carbajal, Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers, World J Gastrointest Pathophysiol. 201766P C Konturek, Yurdagül Zopf[Therapeutic modulation of intestinal microbiota in irritable bowel syndrome. From probiotics to fecal microbiota therapy], MMW Fortschr Med. 201767Heidi Maria Staudacher, Miranda C E Lomer, Freda M Farquharson, Petra Louis, Francesca Fava , Elena Franciosi, Matthias Scholz, Kieran M Tuohy, James O Lindsay, Peter M Irving, Kevin WhelanA Diet Low in FODMAPs Reduces Symptoms in Patients With Irritable Bowel Syndrome and A Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial, Gastroenterology. 201768Brooks D Cash, Emerging role of probiotics and antimicrobials in the management of irritable bowel syndrome, Curr Med Res Opin. 201469Adrian Catinean, Maria Adriana Neag , Kiran Krishnan , Dana Maria Muntean , Corina Ioana Bocsan , Raluca Maria Pop, Andrei Otto Mitre , Carmen Stanca Melincovici , Anca Dana Buzoianu, Probiotic Bacillus Spores Together with Amino Acids and Immunoglobulins Exert Protective Effects on a Rat Model of Ulcerative Colitis, Nutrients. 202070Maurizio Gabrielli, Ernesto Cristiano Lauritano, Emidio Scarpellini, Andrea Lupascu, Veronica Ojetti, Giovanni Gasbarrini, Nicolò Gentiloni Silveri, Antonio Gasbarrini, Bacillus clausii as a treatment of small intestinal bacterial overgrowth, Am J Gastroenterol. 200971Wei Chung Chen, Eamonn M M Quigley, Probiotics, prebiotics & synbiotics in small intestinal bacterial overgrowth: opening up a new therapeutic horizon, Indian J Med Res. 201472Angélica T Vieira , Mauro M Teixeira , Flaviano S Martins, The role of probiotics and prebiotics in inducing gut immunity, Front Immunol. 2013

Metabolism

Probiotic supplements have an overall positive effect on the body’s metabolism.

They are beneficial in the metabolic regulation of insulin, triglycerides, biomarkers of inflammation, hormones, and oxidative stress.73Mehri Jamilian, Fereshteh Bahmani , Zahra Vahedpoor , Ali Salmani , Maryam Tajabadi-Ebrahimi , Parvaneh Jafari , Shahrzad Hashemi Dizaji , Zatollah Asemi , Effects of Probiotic Supplementation on Metabolic Status in Pregnant Women: a Randomized, Double-blind, Placebo-Controlled Trial, Arch Iran Med. 201674Ghodarz Akkasheh , Zahra Kashani-Poor , Maryam Tajabadi-Ebrahimi , Parvaneh Jafari , Hossein Akbari , Mohsen Taghizadeh , Mohammad Reza Memarzadeh , Zatollah Asemi , Ahmad Esmaillzadeh, Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial, Nutrition. 201675Zatollah Asemi , Zohreh Zare, Hossein Shakeri, Sima-Sadat Sabihi, Ahmad Esmaillzadeh, Name of study, Ann Nutr Metab. 201376Batol Zamani , Hamid R Golkar, Shima Farshbaf, Modjtaba Emadi-Baygi , Maryam Tajabadi-Ebrahimi, Parvaneh Jafari, Reyhaneh Akhavan, Mohsen Taghizadeh , Mohammad R Memarzadeh, Zatollah Asemi , Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial, Int J Rheum Dis
. 2016
77Bonnie L Taylor, Georgia E Woodfall , Katherine E Sheedy , Meggan L O’Riley , Kelsie A Rainbow , Elsa L Bramwell , Nicole J Kellow, Effect of Probiotics on Metabolic Outcomes in Pregnant Women with Gestational Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Nutrients. 201778Bernice Man , Mary Dawn Koenig, Beatriz Penalver Bernabe, Unnathi Nagelli, Lisa Tussing-Humphreys, The Role of the Gut Microbiota in the Prevention and Management of Gestational Diabetes Mellitus: Are We There Yet?, J Perinat Neonatal Nurs. 202079Ahmad Zare Javid , Majid Aminzadeh , Mohammad Hosein Haghighi-Zadeh , Mona Jamalvandi, The Effects of Synbiotic Supplementation on Glycemic Status, Lipid Profile, and Biomarkers of Oxidative Stress in Type 1 Diabetic Patients. A Placebo-Controlled, Double-Blind, Randomized Clinical Trial, Diabetes Metab Syndr Obes. 2020

During a research study, participants who received Megasporebiotic reported better ghrelin levels – a hormone that is involved in hunger and satiety.

This demonstrates a positive association between Megasporebiotic and improved metabolic efficiency 80Brian K McFarlin, Andrea L Henning, Erin M Bowman, Melody A Gary, and Kimberly M Carbajal, Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers, World J Gastrointest Pathophysiol. 201781P C Konturek, Yurdagül Zopf[Therapeutic modulation of intestinal microbiota in irritable bowel syndrome. From probiotics to fecal microbiota therapy], MMW Fortschr Med. 201782Heidi Maria Staudacher, Miranda C E Lomer, Freda M Farquharson, Petra Louis, Francesca Fava , Elena Franciosi, Matthias Scholz, Kieran M Tuohy, James O Lindsay, Peter M Irving, Kevin WhelanA Diet Low in FODMAPs Reduces Symptoms in Patients With Irritable Bowel Syndrome and A Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial, Gastroenterology. 201783Brooks D Cash, Emerging role of probiotics and antimicrobials in the management of irritable bowel syndrome, Curr Med Res Opin. 201484Adrian Catinean, Maria Adriana Neag , Kiran Krishnan , Dana Maria Muntean , Corina Ioana Bocsan , Raluca Maria Pop, Andrei Otto Mitre , Carmen Stanca Melincovici , Anca Dana Buzoianu, Probiotic Bacillus Spores Together with Amino Acids and Immunoglobulins Exert Protective Effects on a Rat Model of Ulcerative Colitis, Nutrients. 202085Maurizio Gabrielli, Ernesto Cristiano Lauritano, Emidio Scarpellini, Andrea Lupascu, Veronica Ojetti, Giovanni Gasbarrini, Nicolò Gentiloni Silveri, Antonio Gasbarrini, Bacillus clausii as a treatment of small intestinal bacterial overgrowth, Am J Gastroenterol. 200986Wei Chung Chen, Eamonn M M Quigley, Probiotics, prebiotics & synbiotics in small intestinal bacterial overgrowth: opening up a new therapeutic horizon, Indian J Med Res. 201487Angélica T Vieira , Mauro M Teixeira , Flaviano S Martins, The role of probiotics and prebiotics in inducing gut immunity, Front Immunol. 2013

Megasporebiotic Ingredients

  • Bacillus Licheniformis
  • Bacillus Indicus HU36™
  • Bacillus Subtilis HU58™
  • Bacillus Clausii
  • Bacillus Coagulans

Bacillus Licheniformis

Bacillus Licheniformis is found mainly in the soil.

Bacillus Licheniformis

It has been documented to have anti-obesity and anti-diabetic properties.88Na-Kyoung Lee, Won-Suck Kim, and Hyun-Dong Paik, Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier, Food Sci Biotechnol. 201989Hye Jeong Yang , Dae Young Kwon, Hyun Jin Kim, Min Jung Kim, Do Yeon Jung, Hee Joo Kang, Da Sol Kim, Suna Kang, Na Rang Moon, Bae Keun Shin, Sunmin Park, Fermenting soybeans with Bacillus licheniformis potentiates their capacity to improve cognitive function and glucose homeostaisis in diabetic rats with experimental Alzheimer’s type dementia, Eur J Nutr. 201590Na-Kyoung Lee, Won-Suck Kim , Hyun-Dong Paik, Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier, Food Sci Biotechnol. 201991Fouad M F Elshaghabee , Namita Rokana , Rohini D Gulhane , Chetan Sharma , Harsh Panwar, Bacillus As Potential Probiotics: Status, Concerns, and Future Perspectives, Front Microbiol. 201792Lee, Mi-Sun,Lee, Na-Kyoung , Chang, Kyung-Hoon, Song, Chi-Kwang, Isolation and Characterization of a Protease-Producing Bacterium, Bacillus amyloliquefaciens P27 from Meju as a Probiotic Starter for Fermented Meat Products, Food Science of Animal Resources. 2010

Bacillus Indicus HU36™

Bacillus Indicus HU36™ is the most bio-available source of potent antioxidants.

It is also the only strain to produce antioxidants in the gut, hence reducing inflammation and oxidative stress.93Na-Kyoung Lee, Won-Suck Kim, and Hyun-Dong Paik, Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier, Food Sci Biotechnol. 201994Brian K McFarlin, Andrea L Henning, Erin M Bowman, Melody A Gary, and Kimberly M Carbajal, Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers, World J Gastrointest Pathophysiol. 2017

Bacillus Subtilis HU58™

There is preliminary research suggesting the antimicrobial, antiviral, and anticancer effects of B. subtilis strains like Bacillus Subtilis HU58™.

It has been a common ingredient in both single and mixed types of commercial probiotics.95Na-Kyoung Lee, Won-Suck Kim, and Hyun-Dong Paik, Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier, Food Sci Biotechnol. 201996Massimo Marzorati, Pieter Van den Abbeele, Sarah S. Bubeck, Thomas Bayne, Kiran Krishnan, Aicacia Young, Dilip Mehta, and Anselm DeSouza, Bacillus subtilis HU58 and Bacillus coagulans SC208 Probiotics Reduced the Effects of Antibiotic-Induced Gut Microbiome Dysbiosis in an M-SHIME® Model, Microorganisms. 202097Sayed Yossef, Frances Clark, Sarah S. Bubeck , John Abernethy, Thomas Bayne, Kiran Krishnan, and Aicacia Young, An Oral Formulation of the Probiotic, Bacillus subtilis HU58, Was Safe and Well Tolerated in a Pilot Study of Patients with Hepatic Encephalopathy,hindawi. 2020 98Massimo Marzorati ,Pieter Van den Abbeele ,Sarah S. Bubeck ,OrcID,Thomas Bayne ,Kiran Krishnan ,Aicacia Young ,Dilip Mehta andAnselm DeSouza, Bacillus subtilis HU58 and Bacillus coagulans SC208 Probiotics Reduced the Effects of Antibiotic-Induced Gut Microbiome Dysbiosis in an M-SHIME® Model, Microorganisms 2020

Bacillus Clausii

Bacillus Clausii is known for its immune-modulatory and antimicrobial properties.

Evidence shows that it aids in alleviating nasal symptoms during allergic reactions and has a therapeutic effect against urinary tract infections.99Na-Kyoung Lee, Won-Suck Kim, and Hyun-Dong Paik, Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier, Food Sci Biotechnol. 2019100Gian Luigi Marseglia, Mariangela Tosca, Ignazio Cirillo, Amelia Licari, Maddalena Leone, Alessia Marseglia, Anna Maria Castellazzi, Giorgio Ciprandi, Efficacy of Bacillus clausii spores in the prevention of recurrent respiratory infections in children: a pilot study, Ther Clin Risk Manag. 2007101E C Nista , M Candelli, F Cremonini, I A Cazzato, M A Zocco, F Franceschi, G Cammarota, G Gasbarrini, A Gasbarrini, Bacillus clausii therapy to reduce side-effects of anti-Helicobacter pylori treatment: randomized, double-blind, placebo controlled trial, Aliment Pharmacol Ther. 2004102Vania Patrone , Paola Molinari , Lorenzo Morelli , Microbiological and molecular characterization of commercially available probiotics containing Bacillus clausii from India and Pakistan, Int J Food Microbiol. 2016

Bacillus Coagulans

Bacillus Coagulans is a coagulin producing strain.

As it has bactericidal properties, it is effective against a broad spectrum of enteric microbes.103Na-Kyoung Lee, Won-Suck Kim, and Hyun-Dong Paik, Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier, Food Sci Biotechnol. 2019104B Hyronimus , C Le Marrec, M C Urdaci, Coagulin, a bacteriocin-like inhibitory substance produced by Bacillus coagulans I4, J Appl Microbiol. 1998

Megasporebiotic Dosage

Dosing Megaspore correctly is very important to its effectiveness.

Microbiome Labs knows how potent this probiotic is so they highly encourage you to follow their recommended dosing schedule to get the best results.

bacillus intake

Week 1: 1 capsule every other day.

Week 2: 1 capsule every day

Week 3: 2 capsules simultaneously daily

I personally recommend going even slower by starting week 1 with 1/2 capsule every other day and bumping up to 1 full capsule on week 2.

As you notice symptoms subside titrate down to 1 per day and then eventually 1 per week.

It’s best to take with food.

Safety

Megasporebiotic is generally recognized as safe for consumption as a dietary supplement.

However, there are limited side effects that have been registered in a few clinical studies.

For instance, bacillus probiotics strains may produce biogenic amines and transfer antibiotic resistance genes, but this claim needs further investigation to ensure the safety of their phenotypes and genotype characteristics.105Na-Kyoung Lee, Won-Suck Kim , Hyun-Dong Paik, Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier, Food Sci Biotechnol. 2019106Na-Kyoung Lee, Won-Suck Kim, and Hyun-Dong Paik, Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier, Food Sci Biotechnol. 2019107Anna Zawistowska-Rojek , Stefan Tyski, Are Probiotic Really Safe for Humans?, Pol J Microbiol. 2018108Cindy Duysburgh, Pieter Van den Abbeele, Kiran Krishnan, Thomas F. Bayne, and Massimo Marzorati, A synbiotic concept containing spore-forming Bacillus strains and a prebiotic fiber blend consistently enhanced metabolic activity by modulation of the gut microbiome in vitro, Int J Pharm X. 2019109Tina Didari , Sara Solki, Shilan Mozaffari, Shekoufeh Nikfar, Mohammad Abdollahi, A systematic review of the safety of probiotics, Expert Opin Drug Saf. 2014110Adrian Catinean, Maria Adriana Neag, Kiran Krishnan, Dana Maria Muntean, Corina Ioana Bocsan, Raluca Maria Pop, Andrei Otto Mitre, Carmen Stanca Melincovici, and Anca Dana Buzoianu, Probiotic Bacillus Spores Together with Amino Acids and Immunoglobulins Exert Protective Effects on a Rat Model of Ulcerative Colitis, Nutrients. 2020111Mohammad Z. Asha1, and Sundos F. H. Khalil, Efficacy and Safety of Probiotics, Prebiotics and Synbiotics in the Treatment of Irritable Bowel Syndrome, Sultan Qaboos Univ Med J. 2020

My Personal Review of Megasporebiotic

I’ve been using Megasporebiotic for over 2 years and have found it to be very beneficial.

I was referred to use Megaspore by other health practitioners who use it in their practice to help clients and patients heal major gut disorders.

As someone who has a long history of antibiotic use and subsequent gut issues Megasporebiotic has helped me get my physical and mental health back on track.

I initially used Megaspore as part of their full gut recondition protocol in combination with the prebiotic and MegaMucosa formulas.

These days I add one capsule of Megaspore to my daily morning smoothie as a maintenance protocol.

For clients I work with who experience mental health and gut issues, I regularly recommend Megaspores full gut reconditioning protocol or the gut infection protocol for those experiencing more severe infections.

About the author:

Erik Levi, FNTP

Erik Levi is a co-founder of HolisticNootropics.com and a certified holistic nutritional therapy practitioner.

As an NTP Erik takes a nutrition first approach to health. He has worked with many different people to help them use nutrition to optimize their quality of life.

Erik believes that mental health is a physiological process and cognitive enhancement is not something that can be achieved by just taking some pills with good Amazon reviews.

Instead, true cognitive enhancement comes with the right balance of nutrients, movement, and gratitude. Erik continues to stay up to date with the most current nootropic and holistic health research and promises to deliver the best solutions possible.

You can check out his personal health blog/podcast/YouTube Channel all under the name Holistic A-Hole.

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