Blood Sugar Breakthrough Review + Discount Code

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Medically reviewed by Dr. Darshan Shingala MD, MPH

Key Information

Biotin, Chromium, and Dihydroberberine are some of the key ingredients

These nutrients have been shown to improve glucose metabolism, insulin sensitivity, and diabetic nerve damage.

Bitter Melon, Banaba Leaf, and Cinnamon are some of the herbal extracts

These plants have anti-diabetic effects, such as lowering blood sugar levels, increasing glucose uptake, and enhancing insulin responsiveness.

Alpha-Lipoic Acid is a powerful antioxidant

This compound can protect the cells from oxidative stress caused by high blood sugar levels and prevent diabetic complications.

Blood Sugar Breakthrough is made by BiOptimizers, a reputable wellness brand

BiOptimizers is known for producing high-quality products with research-based formulas and no filler ingredients.

Affiliate Disclosure: Holistic Nootropics may earn affiliate commissions if you purchase through the links on this page. Here's how it works.

To say that modern society is in a metabolic crisis is an understatement.

The modern, western diet has turned most people’s blood sugar into a daily roller coaster that affects every aspect of health and wellness.

As of this writing, 1/10 Americans have diabetes and more than 1/3 have prediabetes.  That doesn’t include many millions more who don’t know they have these diagnoses.1CDC. National Diabetes Statistics Report, 2020 CDC.gove. 2020

The good news is that there are some amazing, natural nutrients that are great for improving blood sugar.

Many of these nutrients are included in the Blood Sugar Breakthrough formula.  

If you’re one of the many people who experience blood sugar dysregulation and its many consequences, check out the following detailed review of this game-changing product.

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Why Stabilizing Blood Sugar Is Important

Adequately balancing your blood sugar levels is the key to regulating your physical, mental, and emotional well-being. Most of your essential body functions, such as hunger, sleep, mood, and energy levels, are glucose-dependent. In other words, optimal daily performance is highly dependent on stable blood glucose levels.

=To do this you must understand the clinically acceptable ranges of blood glucose fluctuations. This is especially important in the management of pre-diabetes or diabetes.

The normal range of blood glucose levels for healthy individuals lies between 72 to 99 mg/dL (4.0 to 5.4 mmol/L) when fasting and up to 140 mg/dL (7.8 mmol/L) measured two hours after eating.2Paris J. Hantzidiamantis; Sarah L. Lappin, Physiology, Glucose StatPearls Publishing; 2021

A measurement between 140 and 199 mg/dL (7.8 mmol/L and 11.0 mmol/L) can be indicative of a prediabetic state, and a measurement of more than 200 mg/dL (11.1 mmol/L) is usually indicative of diabetes.

This is crucial to understand as type 2 diabetes is associated with serious cognitive issues such as depression, anxiety, ADHD, and memory loss.3Giulia Bassi, PhD, Silvia Gabrielli, PhD, Valeria Donisi, PhD, Sara Carbone, MSc,Stefano Forti, PhD, and Silvia Salcuni, PhD, Assessment of Psychological Distress in Adults With Type 2 Diabetes Mellitus Through Technologies: Literature Review J Med Internet Res. 20214Hui-Ju Chen 1, Yann-Jinn Lee, Geng Chang Yeh, Herng-Ching Lin, Association of attention-deficit/hyperactivity disorder with diabetes: a population-based study Pediatr Res. 20135Lindsay A. Zilliox, Krish Chadrasekaran, Justin Y. Kwan, and James W. Russell, Diabetes and Cognitive Impairment Curr Diab Rep. 2017

How Blood Sugar affects Cognition

The adrenal glands, located above the kidneys, secrete a steroid hormone known as cortisol. Cortisol, popularly known as the stress hormone, regulates many functions in the human body, including blood glucose levels.6Daniel Cox , Linda Gonder-Frederick, Anthony McCall, Boris Kovatchev, William Clarke, The effects of glucose fluctuation on cognitive function and QOL: the functional costs of hypoglycaemia and hyperglycaemia among adults with type 1 or type 2 diabetes Int J Clin Pract Suppl. 2002

Cortisol increases the availability of blood glucose to the brain, mainly by enhancing glucose production by the liver and decreasing insulin production by the pancreas. Hence, under conditions of excessive cortisol levels, such as chronic stress, the chances of developing insulin resistance increase drastically.7Lauren Thau; Jayashree Gandhi1; Sandeep Sharma, Physiology, Cortisol StatPearls Publishing. 2021

Metabolism and Mental Health: The Connection Between Blood Sugar, Cortisol, Anxiety, and Depression anxiety and depression Anxiety diabetics diabetes blood sugar metabolic disorders fight or flight panic emergency

At the same time, dysregulated blood sugar from a poor diet can cause excess cortisol and symptoms of overwhelming stress.

Left untreated inability to regulate blood sugar can lead to more serious cognitive disorders.

Symptoms of Dysregulated Blood Sugar

The scientific literature clearly states that poorly regulated blood sugar levels can adversely impact an individual’s physical, mental, and emotional health.8Yun-Beom Sim , Soo-Hyun Park, Yu-Jung Kang, Seon-Mi Kim, Jin-Koo Lee, Jun-Sub Jung, Hong-Won Suh, The regulation of blood glucose level in physical and emotional stress models: possible involvement of adrenergic and glucocorticoid systems Arch Pharm Res. 2010

For instance, high blood glucose levels can significantly damage your blood vessels and nerve endings, leading to a wide range of medical conditions, such as retinopathy, vision loss, kidney failure, neuropathy, and brain stroke.

Dysregulated blood sugar levels are also associated with an increased risk of developing depressive symptoms, mood and affect disorders, declining memory, and dementia.

Symptoms of dysregulated blood sugar include 9NHS UK, Low blood sugar (hypoglycaemia) NHS UK. 2020

  • Sweating
  • Weakness
  • Hunger
  • Dizziness
  • Being easily irritated, tearful, anxious or moody
  • Collapsing or Passing Out
  • Constant Hunger
  • Shakiness

How Diet and Lifestyle Affect Blood Sugar

Your dietary habits and lifestyle choices substantially impact your blood glucose levels. Regardless of whether you are healthy, prediabetic, or diabetic, you must make a conscious effort to maintain a healthy diet and lifestyle.10Alison B Evert , Jackie L Boucher, Marjorie Cypress, Stephanie A Dunbar, Marion J Franz, Elizabeth J Mayer-Davis, Joshua J Neumiller, Robin Nwankwo, Cassandra L Verdi, Patti Urbanski, William S Yancy Jr, Nutrition therapy recommendations for the management of adults with diabetes Diabetes Care. 2014

It is best to avoid inflammatory foods and foods with high glycemic indices, such as sugary drinks, packaged snacks, artificially sweetened juices, and processed foods. Most of these foods contain excessive calories and unhealthy ingredients, such as added sugars, high sodium, high fructose corn syrup, starch, rancid fats, and industrial seed oils, which imbalance your blood sugar levels.11American Diabetes Association, 5. Lifestyle Management: Standards of Medical Care in Diabetes-2019 Diabetes Care. 2019

Besides keeping your diet under check, it is also vital to manage your stress levels effectively since excessive stress can spike your sugar levels due to cortisol production.

Regular movement, exercise, mindfulness, and breathing practices are very useful for stress management.

Why Traditional Multivitamins Don’t help

Gone are the days when simply taking a multivitamin was enough to manage your health.

Most multivitamins lack the specific nutrients needed to adequately manage blood glucose homeostasis.

Many commercially available traditional multivitamins that claim to manage blood sugar levels have been found to be manufactured with cheap, filler ingredients.

Why Blood Sugar Breakthrough Is Great for Blood Sugar Management

Blood Sugar Breakthrough is a highly effective product for managing blood glucose levels.

Its formula composition is comprised of some of the most potent, research-based ingredients that have been scientifically proven to optimize blood sugar levels.

Compared to its competitors, Blood Sugar Breakthrough’s formula is not only more effective but is free from cheap filler ingredients and preservatives that are found in most other formulations.

Blood Sugar Breakthrough’s Main Ingredients:

  • Biotin
  • Chromium
  • Dihydroberberine
  • Bitter Melon
  • Banaba
  • Alpha Lipoic Acid
  • Cinnamon


Biotin is an essential vitamin belonging to the complex of B vitamins. It is involved in many metabolic functions, including processing glucose.

Most importantly, biotin has shown to be effective against diabetic nerve damage due to high glucose levels.12Mitra Hemmati, Homa Babaei, and Mohammadreza Abdolsalehei, Survey of the Effect of Biotin on Glycemic Control and Plasma Lipid Concentrations in Type 1 Diabetic Patients in Kermanshah in Iran Oman Med J. 2013


Research suggests that chromium may enhance the effects of insulin by supporting the endocrine activity of pancreatic cells.

Since chromium also has other health benefits, it can be a good non-pharmaceutical supplemental mineral for diabetic patients.13NIH, Chromium NIH. 202114Skye A McKennon, Kenneth R Feingold, Bradley Anawalt, Alison Boyce, George Chrousos, Wouter W de Herder, Ketan Dhatariya, Kathleen Dungan, Ashley Grossman, Jerome M Hershman, Johannes Hofland, Sanjay Kalra Gregory Kaltsas, Christian Koch, Peter Kopp Márta Korbonits, Christopher S Kovacs, Wendy Kuohung, Blandine Laferrère, Elizabeth A McGee, Robert McLachlan, John E Morley, Maria New, Jonathan Purnell, Rakesh Sahay, Frederick Singer, Constantine A Stratakis, Dace L Trence, Don P Wilson, Non-Pharmaceutical Intervention Options For Type 2 Diabetes: Diets And Dietary Supplements (Botanicals, Antioxidants, and Minerals), Inc.; 2000–.2018 Jun 18


Studies suggest that dihydroberberine may improve tissues’ insulin sensitivity and increase the sugar uptake of cells, thereby reducing blood sugar levels.

Researchers state that berberine can be an effective adjunct therapy for diabetics.15Jiarong Lan , Yanyun Zhao , Feixia Dong , Ziyou Yan , Wenjie Zheng , Jinping Fan , Guoli Sun, Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension Ethnopharmacol. 201516Jun Yin , Huili Xing, Jianping Ye, Efficacy of berberine in patients with type 2 diabetes mellitus Metabolism. 2008

Bitter Melon

Bitter melon or Momordica charantia has some anti-diabetic effects attributable to its medicinal potency.

Studies show that bitter melon has a hypoglycemic effect associated with the suppression of key gluconeogenic enzymes and the preservation of islet β cells.17Baby Joseph* and D Jini, Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency Asian Pac J Trop Dis. 2013


Some preliminary research suggests that banaba leaf extract can improve glycemic management among people with diabetes due to the antidiabetic effect of one of its compounds, namely, corosolic acid.

Corosolic acid can lower blood sugar levels by increasing insulin sensitivity and enhancing the overall glucose uptake.18Lei Shi , Wei Zhang, Yue-Yang Zhou, Yi-Nan Zhang, Jing-Ya Li, Li-Hong Hu, Jia Li, Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation Eur J Pharmacol. 2008

Alpha Lipoic Acid

Alpha-lipoic acid is a powerful antioxidant naturally produced by the liver and found in some superfoods, such as spinach and broccoli.

Alpha-lipoic acid can substantially protect the cells against the oxidative damage caused by high sugar levels among diabetic patients.19Supatra Porasuphatana , Suthi Suddee, Atinuch Nartnampong, Julraht Konsil, Busakorn Harnwong, Adichai Santaweesuk, Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled study Asia Pac J Clin Nutr. 201220L Packer , E H Witt, H J Tritschler, alpha-Lipoic acid as a biological antioxidant Free Radic Biol Med. 1995


Research suggests that cinnamon may lower blood sugar levels by improving the responsiveness of cells to insulin.

In some preliminary studies, cinnamon extract has been shown to reduce fasting and postprandial plasma glucose levels.21Arjuna B Medagama, Name of study Nutr J. 2015


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Erik Abramowitz is a certified Nutritional Therapy Practitioner (NTP), Naturopathic Doctoral student, health coach, and father. He is the primary content creator for and the host of the Holistic Nootropics Podcast.

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