11 Best Nootropics for Ultra-Efficient Intermittent Fasting!

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Last Updated:
Key Takeaways:

Intermittent fasting is a hot diet trend that has significant clinical evidence behind it

There are a number of nootropic supplements that can help you transition into and maintain an IF schedule

Some of these nootropics can regulate blood sugar and hunger levels

Other nootropics may enhance the beneficial processes that occur during IF, making the diet more effective

Affiliate Disclosure: Holistic Nootropics will earn affiliate commissions if you purchase through the links on this page. Here's how it works.

11 Best Nootropics for Ultra-Efficient Intermittent Fasting!

Intermittent fasting is a rapidly growing health trend based on skipping meals at regular intervals. It has been practiced around the world for thousands of years, often for religious reasons. Now, modern nutritional science is starting to confirm its various health benefits.

This method encompasses eating patterns in which you might go from 12 to as long as 48 hours with little or no energy intake. It is broken up by intervening periods of normal food intake.1Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes Ageing Res Rev. 2017

What Are The Best Nootropics For Intermittent Fasting – Quick Answers

Blood Sugar Breakthrough

Blood Sugar Breakthrough

#1 Blood Sugar Support Supplement
Learn MoreSave add’l 10% w. code HOLISTICNOOTROPICS @ checkout
Magnesium Breakthrough

Magnesium Breakthrough

#1 Magnesium Product
Learn MoreUse code: HOLISTICNOOTROPICS to save 10%
Mind Lab Pro

Mind Lab Pro

Science-backed nutrition for your brain
Learn MoreBuy 3 bottles, get 1 free with our links
Cordyceps Mushroom

Cordyceps Mushroom

The Mushroom for Energy
Qualia Mind

Qualia Mind

Most Nootropics Per Serving
Reishi - Real Mushrooms

Reishi – Real Mushrooms

Calming, Mood Enhancing
Phosphatidylserine - Nootropics Depot

Phosphatidylserine – Nootropics Depot

#1 Stress Management Nootropic


Crucial component of all neural cells


Boost Your Brainpower


Reduce anxiety and improve sleep
NALT (L-Tyrosine)

NALT (L-Tyrosine)

Potent dopamine precursor


Boost acetylcholine in the brain


Most Powerful Stress Resistance Herb
Rhodiola Rosea

Rhodiola Rosea

natural way to reduce fatigue


Over-the-counter version of Modafinil
Learn MoreSave 15% w code “holisticnootropics”@ Checkout

What Is Intermittent Fasting?

The most typical intermittent fasting routines include:

  • 16/8: fasting for 16 hours every day, then eating during an 8-hour window in the evening.
  • 1-on-1-off: fasting for 24 hours every other day
  • 5/2: fasting for 48 hours once every week.

Regardless of the schedule, many people report a wide variety of physical and mental improvements from fasting at scheduled intervals.

intermittent fasting, nootropics
Intermittent fasting is a great biohack for optimizing cellular function.

Intermittent Fasting Health Benefits

One of the major reasons people turn to intermittent fasting is for weight loss. People have used calorie restrictions practically forever as a method to shed pounds. Obviously, eating less means less caloric intake, which means (hopefully) losing weight.

Read More: Why You Should Never Buy Nootropics From Amazon

However, most of these restricted-calorie methods have mixed results. But, while intermittent fasting can be considered a form of calorie restriction, the time-restricted feeding structure actually leads to more profound results.

Some of the major benefits of intermittent fasting over typical calorie restriction include better insulin and blood sugar control, increased metabolic rate, and more balanced hormone levels (including higher levels of Human Growth Hormone).2Mansell PI, Fellows IW, Macdonald IA. Enhanced thermogenic response to epinephrine after 48-h starvation in humans Am J Physiol. 19903K Y Ho, et al. Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man J Clin Invest. 1988

This may allow for more sustainable, effective weight loss over the long term.

There is clinical evidence that intermittent fasting may also be able to treat:4Mizushima N. Autophagy: process and function Genes Dev. 2007 5Choi KS. Autophagy and cancer Exp Mol Med. 2012 6Louiza Belkacemi, et al. Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats International Journal of Endocrinology. 2012

  • Diabetes
  • Heart conditions
  • Preventing free-radical damage
  • Metabolic disorders

Not eating for extended periods of time allows your body to clean up and eliminate intracellular waste. This necessary process can help overall cellular function and prevent disease.7Mehrdad Alirezaei, et al. Short-term fasting induces profound neuronal autophagy, Autophagy. 2010

Brain Benefits Of Fasting

Many intermittent fasting enthusiasts report feeling more clear-headed, focused, and mentally sharp while following this schedule.

It’s also possible that intermittent fasting can also help with mental issues like:

Sticking to an intermittent fasting routine is not only helpful for your physical health. It can also have profound effects on cognition and mental function.

best nootropics for intermittent fasting
In addition to physical benefits, fasting may also give you a mental edge.

Research shows that intermittent fasting can increase Brain-Derived Neurotrophic Factor and glial cell line-derived neurotrophic factor. These are powerful mechanisms that contribute to brain-plasticity and neurogenesis.8Navin Maswood, et al. Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson’s disease PNAS. 2004

Intermittent fasting has also been shown to improve memory and prevent memory loss.9Shin BK, et al. Intermittent fasting protects against the deterioration of cognitive function, energy metabolism and dyslipidemia in Alzheimer’s disease-induced estrogen deficient rats Exp Biol Med. 2018

There is also evidence that this regimen can help treat the symptoms of neurodegenerative disorders such as Alzheimer’s and Parkinson’s.10Halagappa VK, et al. Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer’s disease Neurobiol Dis. 2007 11Xiang Bai, et al. Rapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathy Pathobiology of Aging & Age-related Diseases. 2015

Can Intermittent Fasting Cause Brain Fog?

Many people claim that this routine can lift brain fog and give them more overall mental clarity.

According to some research, longer fasts can be associated with higher cognitive abilities.12Rima Solianik, et al. Effect of 48 h Fasting on Autonomic Function, Brain Activity, Cognition, and Mood in Amateur Weight Lifters Biomed Res Int. 2016

However, other people find that going long stretches without food makes them foggy-headed and irritable. For many, this will clear up after a few days or weeks of intermittent fasting, after their body adjusts to the new routine.

For others, it will continue causing issues, and so they may need to quit the fasting schedule. Everybody is different, and the most important thing is to listen to yours.

If you have problems thinking clearly that do not relent after your initial couple of intermittent fasting, it simply might not be for you.

So, while it does seem like sticking to a fasting routine can lift brain fog for many people, it all ultimately comes down to the individual.

Intermittent fasting, best nootropics
Intermittent fasting is essentially just restricting your mealtimes to certain hours of the day.

When To Take Nootropics While Fasting

In general, we don’t recommend taking these nootropics while actively fasting, as most of these are better absorbed with food.

Best Nootropics For Intermittent Fasting

If you are currently on or considering an intermittent fasting schedule, some nootropics may have some specific benefits for you.

Best Nootropics for Intermittent Fasting

#1 Blood Sugar Support Supplement

Blood Sugar Breakthrough

Blood Sugar Breakthrough
Shop NowSave add’l 10% w. code HOLISTICNOOTROPICS @ checkout
Shop NowSave add’l 10% w. code HOLISTICNOOTROPICS @ checkout
  • Most potent blend of blood sugar stabilizing ingredients on the market today

  • 100mg of Dihydroberberine per serving (2 capsules)

  • Supports Stable Blood Sugar Levels

  • All-Natural ingredients including herbals, amino acids, vitamins, and minerals

  • Product manufactured in USA according to highest GMP-certified standards

  • 30 servings per bottle (2 capsules/serving)

  • Free shipping and added discounts available


  • Contains natural ingredients that have been clinically proven to help lower blood sugar levels
  • Has been shown to help people lose weight
  • comes with a money-back guarantee, so you can feel confident that you’re not wasting your money if it doesn’t work for you
  • Produced by BiOptimizers, one of the most trusted names in the Supplement Industry


  • Can be a bit pricey
  • Encapsulation includes magnesium stearate, and silicon dioxide (not toxic at low levels, but not 100% clean)

Blood Sugar Breakthrough is the most advanced blood sugar stabilizing formula on the market.

It includes a blend of research-based ingredients that optimize blood sugar levels by increasing your body’s insulin sensitivity.

This is the perfect supplement for intermittent fasting which is also meant to sensitize your cells to insulin and lower blood glucose.1Stephen D. Anton, Keelin Moehl, William T. Donahoo, Krisztina Marosi, Stephanie Lee, Arch G. Mainous, III, Christiaan Leeuwenburgh, and Mark P. Mattson, Flipping the Metabolic Switch: Understanding and Applying Health Benefits of Fasting, Obesity (Silver Spring). 2018 2Martin M. Grajower1 and Benjamin D. Horne, Clinical Management of Intermittent Fasting in Patients with Diabetes Mellitus, Nutrients. 2019

The compounding effects of Blood Sugar Breakthrough Formula while intermittent fasting can 10x your blood glucose management, boost overall metabolism, and increase your results.3Rona Antoni , Kelly L Johnston , Adam L Collins , M Denise Robertson, Effects of intermittent fasting on glucose and lipid metabolism, Proc Nutr Soc. 2017

#1 Magnesium Product

Magnesium Breakthrough

Magnesium Breakthrough
Shop NowUse code: HOLISTICNOOTROPICS to save 10%
Shop NowUse code: HOLISTICNOOTROPICS to save 10%
  • Magnesium restores balance to the mind and body

  • Improves symptoms of ADHD in some people

  • Triggers relaxation response

  • Steadies the mind for restful sleep


  • Includes the 7 most effective forms of magnesium
  • Highly credible manufacturer
  • No added fillers, preservatives, or unnecessary ingredients
  • Free shipping and discounts are available


  • Underdosed for specific magnesium type you may want

During intermittent fasting, we are at a higher risk for electrolyte deficiency, muscle cramps and insomnia.

A few studies suggest that consuming magnesium during intermittent fasting may enhance the overall outcome.4Arlet V. Nedeltcheva, MD, Jennifer M. Kilkus, MS,2 Jacqueline Imperial, RN,2 Dale A. Schoeller, PhD,3 and Plamen D. Penev, MD, PhD, Insufficient sleep undermines dietary efforts to reduce adiposity, Ann Intern Med. 2010

This is because, magnesium performs a bunch of essential functions including, maintenance of cell membrane function, fluid/ electrolyte balance, regulation of potassium and calcium.5Nicola Veronese, Jacopo Demurtas, Gabriella Pesolillo, Stefano Celotto, Tommaso Barnini, Giovanni Calusi, Maria Gabriella Caruso, Maria Notarnicola, Rosa Reddavide, Brendon Stubbs, Marco Solmi, Stefania Maggi, Alberto Vaona, Joseph Firth, Lee Smith, Ai Koyanagi, Ligia Dominguez & Mario Barbagallo, Magnesium and health outcomes: an umbrella review of systematic reviews and meta-analyses of observational and intervention studies, European Journal of Nutrition. 2020

Hence, it is recommended to increase the intake of dietary magnesium during intermittent fasting to avoid muscle contractions, promote enzymatic reactions, and produce optimum energy during long fasting periods.6Behnood Abbasi , Masud Kimiagar, Khosro Sadeghniiat, Minoo M Shirazi, Mehdi Hedayati, Bahram Rashidkhani, The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial, J Res Med Sci. 2012

Magnesium has also been found to upregulate melatonin levels, which eventually improves the quality of sleep and helps with insomnia associated with intermittent fasting.
Magnesium Breakthrough contains several forms of dietary magnesium which support healthy fat loss, and promote sound sleep. This supplement comprises cofactors such as B6, manganese and “monoatomic magnesium” which boosts the absorption of magnesium in the body.

Science-backed nutrition for your brain

Mind Lab Pro

Mind Lab Pro
Shop NowBuy 3 bottles, get 1 free with our links
Shop NowBuy 3 bottles, get 1 free with our links
  • Designed to optimize cognitive functions through 11 natural ingredients that work in 6 bio-pathways

  • Boosts serotonin levels which can help improve your mood, sleep quality, appetite control, stress management,

  • Mind Lab Pro helps improve focus, memory, clarity, energy levels without relying on stimulants or artificial additives

  • Contains premium forms of each ingredient for enhanced potency and activity, while avoiding potential side effects associated with lower quality ingredients


  • Proven to boost overall cognitive performance including memory, focus, mood, creativity, motivation, and overall well-being.
  • Potent blend of all-natural nootropics, herbs, amino acids, vitamins, and minerals.
  • Good for experienced biohackers and those new to nootropics.
  • Caffeine Free
  • No artificial fillers or toxic preservatives
  • Affordable Price, money back guarantee


  • Ingredients are lower dosed.

Mind Lab Pro’s comprehensive yet simplistic formula is excellent for intermittent fasting.

Ingredients like Lion’s Mane and CDP-Choline work synergistically with your body as it shifts into fat-burning mode.

The adaptogens and L-theanine will also help control the cortisol response that comes from any fasting stress.

You also get B-vitamin co-factors to enhance absorbability.

The supplements themselves are 3rd party tested and free of excess fillers and toxic ingredients.

I love this stack for nootropic newbies and experienced nootropic users alike.

The Mushroom for Energy

Cordyceps Mushroom

  • Improve your stamina and energy levels

  • Helps improve your respiratory function and blood circulation

  • Potent anti-inflammatory and antioxidant effects

  • Helps ncrease the oxygen intake (VO2 max)


  • Available in capsules and powder form
  • Can protect against health problems like asthma, depression, diabetes, fatigue, high cholesterol, and upper respiratory tract infections.
  • Has been shown to improve athletic performance and reduce fatigue.
  • All-natural


  • Quality cordyceps can be quite expensive and hard to find

Cordyceps is an adaptogenic nutrient-dense herb. It also contains multiple trace minerals which makes it the perfect food item to take during or after intermittent fasting.

Consuming cordyceps while intermittent fasting supports and stabilizes your body and brings it back to balance.7Ashok Kumar Panda and Kailash Chandra Swain, Traditional uses and medicinal potential of Cordyceps sinensis of Sikkim, J Ayurveda Integr Med. 2011

As per scientific literature, cordyceps contains numerous complex compounds with the aptitude not only to enhance the immune system response but also to modulate its response.8Gitishree Das,Han-Seung Shin,Gerardo Leyva-Gómez,María L. Del Prado-Audelo,Hernán Cortes,Yengkhom Disco Singh,Manasa Kumar Panda,Abhay Prakash Mishra,Manisha Nigam,Sarla Saklani,Praveen Kumar Chaturi,Miquel Martore,Natália Cruz-Martins,Vineet Sharma,Neha Garg,Rohit Sharma,Jayanta Kumar Patra, Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials, Front. Pharmacol., 2021

Adding this to your fasting period will help you intensify mental caliber, improve attention span, and prevent stress, anxiety, and fatigue.9E J Buenz , B A Bauer, T W Osmundson, T J Motley, The traditional Chinese medicine Cordyceps sinensis and its effects on apoptotic homeostasis, J Ethnopharmacol. 2005

Freshcap Mushrooms provide the highest percentage of beta glucans and fruiting body nutrients, making this mushroom product my preferred choice for Cordyceps.

Most Nootropics Per Serving

Qualia Mind

  • Most advanced preformulated nootropic stack on the market.

  • Packed with 28 cognitive-enhancing ingredients each clinically proven to boost cognition

  • Preferred nootropic product for many top biohackers and wellness professionals

  • Available in both caffeinated and decaffeinated versions

  • Qualia Focus is the sister product to Qualia Mind and comes with fewer ingredients


  • Most advanced nootropic formula on the market
  • All-natural ingredients
  • Clean formula: No toxic fillers or necessary preservatives
  • Many positive user testimonials
  • Option for less potent Qualia Focus Available
  • Over 50% off 1st Bottle
  • Use “15INSAVINGS” For Additional 15% Off


  • Large dose of 7 pills
  • More expensive than most other nootropics
  • More ingredients not always better.

Qualia Mind’s comprehensive formula is an excellent complement for anyone looking to optimize intermittent fasting’s many mental benefits.

Feeding your brain the 28 neuro-compounds included in Qualia’s formula help boost your mind as it begins burning fat for fuel.

You’ll experience more motivation, more energy, fewer cravings, and better metabolism.

This stack is great for more experienced biohackers or anyone who needs a significant boost in brainpower.

Calming, Mood Enhancing

Reishi – Real Mushrooms

  • Promotes long-term focus and mental energy

  • Stimulate neurogenesis

  • Boosts immune system

  • Calm effects on central nervous system


  • May help improve sleep quality and reduce stress levels
  • Can be consumed in many different forms, such as capsules, powders, teas, and tinctures
  • Used in Asia for centuries as a medicinal mushroom


  • Common side effects include gastrointestinal upset and nausea
  • Not recommended for people with autoimmune disease or taking immunosuppressive medication

Studies have found that the polysaccharides and triterpenes present in Reishi mushrooms promote the mechanism of cellular autophagy making it a perfect addition to your intermittent fasting routine.10Haitao Pan, Yujie Wang, Kun Na, Ying Wang, Lu Wang, Zhenhao Li, Chengjie Guo, Dandan Guo & Xingya Wang, Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation, Cell Death & Disease. 201911Anita Thyagarajan, Andrej Jedinak, Hai Nguyen, Colin Terry, Lee Ann Baldridge, Jiahua Jiang, Daniel Sliva, Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK), Nutr Cancer. 2010

Both Reishi mushrooms and intermittent fasting stimulate the lysosomes in the cells to consume the damaged cellular structures, thus promoting regenerative processes at a cellular level.12Mohammad Bagherniya , Alexandra E Butler , George E Barreto , Amirhossein Sahebkar, https://pubmed.ncbi.nlm.nih.gov/30172870/” target=”_blank” rel=”noopener noreferrer”>The effect of fasting or calorie restriction on autophagy induction: A review of the literature, Ageing Res Rev. 2018

Due to their similar mechanisms of action, when combined together, Reishi and intermittent fasting can have an additive beneficial effect on the overall health outcome.

Freshcap Mushrooms provide the highest percentage of beta glucans and fruiting body nutrients, making this mushroom product my preferred choice for Reishi.

#1 Stress Management Nootropic

Phosphatidylserine – Nootropics Depot

  • Phosphatidylserine is an abundant phospholipid in the brain

  • Shown to improve cognitive function in people with age-related cognitive decline

  • Help reduce inflammation and protect nerve cells from damage

  • Crucial in cellular membrane function and protection


  • A powerful antioxidant that helps to protect cells from damage
  • Help improve cognitive function in people with Alzheimer’s disease and other forms of dementia
  • Found naturally in foods like eggs and fish
  • It may help boost exercise capacity and improve athletic performance


  • Can cause some side effects, including gastrointestinal upset, headaches, and insomnia
  • It may have a blood-thinning effect, precaution should be taken to people taking blood-thinning medication

This amino acid is critical for overall metabolism.

L-Glutamine helps maintain the integrity of your gut lining. This helps both digestion and immune function regulation during fasting.13Mignon M, Beaufrère AM, Combaret L, Meynial-Denis D. Does long-term intermittent treatment with glutamine improve the well-being of fed and fasted very old rats?, JPEN J Parenter Enteral Nutr. 2007

Phosphatidylserine is a naturally occurring phospholipid that makes up a significant part of every cell membrane in your body. It may be useful to supplement this compound while your body is in a fasting state.

It can help with blood glucose regulation which may enhance the benefits of fasting, including lowering stress.14Michael A Starks, et al. The effects of phosphatidylserine on endocrine response to moderate intensity exercise, Journal of the International Society of Sports Nutrition. 2008

Intermittent fasting is known to increase a process called apoptosis, or clearing out cellular waste. According to research, phosphatidylserine can help identify cells for clearance in apoptosis. This may increase the efficiency of this process.

This could have a broad range of benefits for mental and physical processes, as well as treat the symptoms of a number of disorders.15R B Birge. Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer, Cell Death And Differentiation. 2016

Crucial component of all neural cells


  • Supports cognitive function and memory

  • May improve attention and learning ability

  • Plays a role in cell signaling, metabolism, and transport of lipids

  • A major source of choline, which is necessary for acetylcholine synthesis

Phosphatidylcholine is the counterpart of phosphatidylserine, and together they compose large amounts of your cell membranes.

This nootropic supplement can increase the function of the liver and aid in transporting lipids.16Author links open overlay panelSergio O.Serna-SaldivarJanet A.Gutiérrez-UribeSilverioGarcía-Lara. Phytochemical Profiles and Nutraceutical Properties of Corn and Wheat Tortillas, Wheat Flour and Corn Products. 2015

During starvation, your liver breaks down lipids in the bloodstream in a process called macrolipophagy. This is an important process that can regulate metabolism and possibly prevent some metabolic disorders.17Singh R, et al. Autophagy regulates lipid metabolism, Nature. 2009

Phosphatidylcholine can theoretically support this process while you are fasting.

Boost Your Brainpower


  • Amino acid that is found naturally in the body

  • Shown to improve memory and attention

  • Shown to boost metabolism and help people lose weight

  • Found in foods like meat, dairy, and vegetables


  • Boost immune system function
  • Promotes regulation of cell growth and function
  • Help to reduce inflammation in animal studies, and it may also be effective in humans
  • It May help speed recovery from injuries
  • Prevents upper respiratory tract infections
  • Sold in powder, capsule, and tablet form


  • Some people may experience side effects such as bloating, abdominal pain, and diarrhea
  • Can increase the risk of seizures and can worsen severe liver conditions in some people
  • Some people may experience shortness of breath, headache, swelling on the face or lips, and sore throat after taking the supplement.

This amino acid is critical for overall metabolism.

L-Glutamine helps maintain the integrity of your gut lining. This helps both digestion and immune function regulation during fasting.18Mignon M, Beaufrère AM, Combaret L, Meynial-Denis D. Does long-term intermittent treatment with glutamine improve the well-being of fed and fasted very old rats?, JPEN J Parenter Enteral Nutr. 2007

Glutamine has been shown to improve gut and colon barrier function, which could ultimately help brain function through the gut/brain axis.19Clément L’Huillier. Glutamine, but not Branched-Chain Amino Acids, Restores Intestinal Barrier Function during Activity-Based Anorexia, Nutrients. 2019

Reduce anxiety and improve sleep


  • Improve mood and reduce anxiety

  • Improve sleep quality

  • Reduce stress levels

  • Regulate communication between neurons

  • Support stress response

GABA is an amino acid and neurotransmitter that is often described as the “brakes” of the central nervous system. It can also affect glucose and insulin levels, possibly making GABA supplements useful for fasters.

GABA and GABA-enriched natural products can be effective agents in lowering blood glucose, attenuating insulin resistance, and stimulating insulin release.20Soltani N, et al. GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes, Proc Natl Acad Sci U S A. 2011

In one study, GABA significantly reduced the concentrations of fasting blood glucose, and improved glucose tolerance and insulin sensitivity in the High Fat Diet-fed mice. More importantly, after the onset of obesity, GABA inhibited the continued weight-gain and stabilized insulin and glucose levels.21Tian J, et al. Oral treatment with γ-aminobutyric acid improves glucose tolerance and insulin sensitivity by inhibiting inflammation in high fat diet-fed mice, PLoS One. 2011

This means that GABA supplementation may help your body stabilize during intermittent fasting.

Potent dopamine precursor

NALT (L-Tyrosine)

  • NALT is a precursor to important neurotransmitters like dopamine

  • Helps boost dopamine levels, which can improve mood and sleep

  • May help with anxiety and depression

  • Can be used as an alternative to ADHD drugs

  • Helps boost energy and motivation


  • Non-addictive and has few side effects
  • Does not interact with other medications, so it can be taken safely by people who are taking other medications for other conditions
  • Relatively inexpensive and is covered by many insurance plans


  • Can cause withdrawal symptoms in people who stop taking it suddenly
  • Can also cause liver damage, so people with liver problems should not take nalt

N-acetyl L-tyrosine, or NALT, is a potent derivative of the essential amino acid L-tyrosine. Both NALT and L-tyrosine convert rapidly into dopamine, one of your body’s most important neurotransmitters.

Fasting can (naturally) cause you to experience mental and physical stress. Luckily, studies show that NALT helps cognitive ability while under stress.22O’Brien C, et al. Dietary tyrosine benefits cognitive and psychomotor performance during body cooling, Physiol Behav. 2007

NALT can help with overall mood and behavioral deficits that may come as a result of the stress of intermittent fasting. This may be especially relevant as you start a fasting routine and your body adjusts.23Lehnert H, Reinstein DK, Strowbridge BW, Wurtman RJ. Neurochemical and behavioral consequences of acute, uncontrollable stress: effects of dietary tyrosine, Brain Res. 1984

So, this could be a good option to maintain cognitive function while fasting for extended periods.

Boost acetylcholine in the brain


  • Supports cognitive function and memory

  • Neuroprotective effects may help reduce risk of age-related cognitive decline

  • Can improve exercise performance

  • Increases growth hormone levels

Alpha-GPC is a direct, highly-bioavailable source of choline, which is an essential nutrient. Adding Alpha GPC to your stack can work as a sort of neurohack to increase overall brain processing and problem-solving.24Amenta F, Parnetti L, Gallai V, Wallin A. Treatment of cognitive dysfunction associated with Alzheimer’s disease with cholinergic precursors. Ineffective treatments or inappropriate approaches?, Mech Ageing Dev. 2001

Choline has many neurological benefits, and it can overall enhance the mental benefits of intermittent fasting.25Parnetti L, Amenta F, Gallai V. Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data, Mech Ageing Dev. 2001

Alpha-GPC can enhance inter- and intra- cell communication, which is important during the cellular cleanup work that happens during intermittent fasting.26Zeisel SH, Blusztajn JK. Choline and human nutrition, Annu Rev Nutr. 1994

As a supplement, it may be good for helping maintain strength for those who may feel weak and nutrient deficient after fasting.27Tim Ziegenfuss, et al. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise, Journal of the International Society of Sports Nutrition. 2008

Most Powerful Stress Resistance Herb


  • Improved cognitive function

  • Increased energy levels

  • Enhanced stress resistance

  • Modulates neurotransmitter activity


  • Has been shown to help improve memory and cognitive function
  • Helps reduce anxiety and stress levels, as well as improve sleep quality
  • Strong anti-inflammatory agent, making it helpful for conditions like arthritis and asthma
  • Can help reduce blood sugar levels
  • Studies show taking ashwagandha can reduce cholesterol levels, helping to reduce high cholesterol levels
  • Can be taken daily


  • Should be avoided by pregnant women and those who are breastfeeding
  • Can interfere with diabetes medicines
  • Should be avoided by those with thyroid disorders
  • May cause some stomach upset such as diarrhea and vomiting

Ashwagandha is a powerful adaptogenic herb that has been used in traditional medicine for millennia to combat stress and balance hormones.

Fasting can induce physical stress and tilt the autonomic nervous system more towards sympathetic responses (stress responses).28Solianik R, Sujeta A. Two-day fasting evokes stress, but does not affect mood, brain activity, cognitive, psychomotor, and motor performance in overweight women, Behav Brain Res. 2018

Luckily, there is evidence that ashwagandha can help control and lower cortisol output to help relax the body during fasting-induced stress.29Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults, Indian J Psychol Med. 2012

According to research, ashwagandha can lead to a statistically significant reduction in anxiety, depression, and overall stress ratings, as well as an increase in testosterone in men.30Lopresti AL, et al. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study, Medicine (Baltimore). 2019

natural way to reduce fatigue

Rhodiola Rosea

  • Used in traditional medicine for centuries

  • Natural way to improve mental performance and stamina

  • Can help reduce fatigue

Similar to ashwagandha, Rhodiola rosea is an adaptogen with a long history of use for stress relief and increased mental ability.

This herb has adaptogenic and stimulatory qualities to help keep you energized and alert during times of fasting and keep your mental acuity high.

Taking Rhodiola can boost learning and memory as well. Even one dose of Rhodiola extract was found to improve learning and memory in rats. Researchers suspect that this is most likely due to its adaptogenic qualities.

As you may imagine, by boosting mood and lowering anxiety/stress, you indirectly give your brain more energy to use on productively.31Petkov VD, et al. Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory, Acta Physiol Pharmacol Bulg. 1986

Rhodiola can significantly increase stamina and energy. Young military cadets who took Rhodiola extract performed much better on cognitive tests after engaging in physically strenuous activity.

They were consistently more alert and “on top of it” compared to their counterparts who took a placebo. They even showed lower physiological measures of fatigue, such as blood pressure and heart rate.32Shevtsov VA, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work, Phytomedicine. 2003

This makes Rhodiola a great overall nootropic for anyone interested in fasting.

Over-the-counter version of Modafinil


Buy From Nootropics UnlimitedSave 15% w code “holisticnootropics”@ Checkout
Buy From Nootropics UnlimitedSave 15% w code “holisticnootropics”@ Checkout
  • Increases energy and productivity

  • Helps to stay awake and focused over long periods of time

  • Combats drowsiness without sacrificing sleep quality

  • Improves your overall mood


  • Adrafinil has been shown to improve working memory, executive function, and vigilance in healthy adults.
  • In one study, adrafinil was found to be as effective as methylphenidate (Ritalin) at reducing ADHD symptoms.
  • May also help to improve cognitive function in people with Alzheimer’s disease and other forms of dementia.
  • Can help you stay awake longer


  • Most common side effects reported are headache, nausea, and anxiety.
  • Adrafinil is a schedule IV controlled substance in Canada and is classified as a prescription drug.
  • not currently approved by the FDA

Usually, modafinil (and it’s prodrug adrafinil) are considered stimulant/anti-narcolepsy drugs.

But, there is clear evidence that modafinil/adrafinil can also decrease appetite. Obviously this may be useful if you are attempting to fast.33Perez GA, et al. Modafinil decreases food intake in humans subjected to simulated shift work, Pharmacol Biochem Behav. 2008

Keep in mind that these nootropics are a bit stronger than some of the others on this list, and may have more side-effects.

Modafinil requires a prescription in most places (including the US), but adrafinil is an over the counter supplement.

Where to Buy Adrafinil:

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Wrapping Up

Have you been intermittent fasting? What’s been your secret to success? Let us know in the comments!

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Erik Abramowitz is a certified Nutritional Therapy Practitioner (NTP), Naturopathic Doctoral student, health coach, and father. He is the primary content creator for HolisticNootropics.com and the host of the Holistic Nootropics Podcast.

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