Alpha-GPC: Benefits, Dosing, Where To Buy, And More!

Hey there! Welcome to my review of Alpha GPC.

I spent over 15 hours researching and testing Alpha GPC. I read everything from Pubmed studies to online user reviews, and then even tried some myself to understand what this compound is all about.

My conclusion is that Alpha GPC is by far one of the most potent nootropic compounds on the market today.

Supplementing with Alpha GPC is a great way to boost all areas of cognition for immediate benefits, but also a proven method for protecting your brain from neurodegeneration in the long run.

The best part is that most Alpha GPC nootropic supplements are affordable, easy to buy, and are low-risk to use.

Ready to learn more? Let’s go!

What Is Alpha GPC?

Alpha GPC is a choline source synthesized from sunflower or soy.

Alpha GPC (α-Glycerophosphocholine) is a popular nootropic supplement that can improve memory and learning, boost mood and energy, and prevent cognitive decline.

Choline is an essential nutrient that can also be found in food, particularly eggs. It’s required for many basic processes inside cells and critical for proper brain development.

Alpha GPC happens to be a more bioavailable form of choline that can easily cross the blood-brain barrier. ¹Alpha GPC happens to be a more bioavailable form of choline that can easily cross the blood-brain barrier. ²

Once absorbed by the body, Alpha GPC increases a critical neurotransmitter called acetylcholine (ACh).

Acetylcholine is one of the most abundant neurotransmitters in the central nervous system. It is heavily involved in learning, memory, and emotions. Maintaining proper ACh levels can optimize cognitive function.³⁴

Alpha GPC is a common part of nootropic stacks and is often paired with racetams (oxiracetam, aniracetam, etc..).

This is because racetams can deplete choline stores. Stacking with a choline source like Alpha GPC can prevent this from happening and synergize the nootropic effects of both substances.

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Alpha GPC is a standard part of most nootropic stacks and pairs well with racetams (oxiracetam, aniracetam, etc..).

This is because racetams can deplete choline stores. Stacking with a choline source like Alpha GPC can prevent this from happening and synergize the nootropic effects of both substances.

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What Are Some Alpha-GPC Benefits?

Alpha GPC is used for many different purposes. It is clinically proven to treat some brain injuries but may also have nootropic benefits for otherwise healthy people.

Alpha GPC Is Neuroprotective

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There is evidence that Alpha GPC has neuroprotective benefits.

Numerous trials show that it can improve overall cognition while preventing cognitive degeneration due to it’s action on the acetylcholine system.⁷

A large review of human clinical studies on dementia or hypertensive-related mental decline suggests that Alpha GPC can significantly improve cognitive function compared to control or placebo.⁸

In one small trial of adults suffering from cognitive decline, Alpha GPC “had a significant positive effect on patients’ condition including cognitive function.” Researchers noted an improvement in as little as 5-6 days.⁹

Alpha GPC May Heal Damage From Stroke

In rats, Alpha GPC countered the neural damage caused by stroke. Researchers noted that it countered nerve cell loss in the rats that suffered from hypertension.¹⁰

Alpha GPC For Amnesia

Experimental and clinical studies have documented that Alpha GPC is able to counter the amnesia induced by scopolamine. Scopolamine is an anticholinergic, meaning it stops the flow of ACh in the brain. This action causes memory loss.

Alpha GPC can counter this effect when it is administered, indicating how it can act as a neuroprotectant by its action on ACh.¹¹

Alpha GPC For Traumatic Brain Injuries

It seems that Alpha GPC can even potentially treat traumatic brain injuries.

One study looked at patients who had received serious concussions.

After three months of supplementing with Alpha GPC, 96% of the participants saw significant improvement in cognitive functioning.¹²

Alpha GPC For Parkinson’s Disease

One study looked at the combination of Alpha GPC and piracetam (a common nootropic stack) on patients with Parkinson’s.

Researchers noted that patients with Parkinson’s Disease who were prescribed Alpha GPC in addition to piracetam experienced greater general cognitive status and quality of life than in those just given piracetam.¹³

Alpha GPC and Alzheimer’s/Dementia

Alpha GPC seems to be a promising treatment for Alzheimer’s.

There are multiple human studies that implicate choline and acetylcholine dysfunction in this disease.

It appears that by modulating ACh levels, Alpha GPC can treat and even partially reverse some of the symptoms of Alzheimer’s.¹⁴¹⁵¹⁶¹⁷

Is Alpha GPC A Growth Hormone?

Alzheimer’s is also related to growth hormone decline. Alpha GPC can raise levels of growth hormone through its modulation of ACh.

So, it seems that this compound can treat Alzheimer’s through this pathway as well, providing multiple benefits.¹⁸¹⁹²⁰

Alpha GPC and Memory

Alpha GPC is not only useful for preventing cognitive decline or warding off diseases like Alzheimer’s and Parkinson’s.

The same mechanism that makes Alpha GPC useful as a neuroprotectant that fights Alzheimer’s and Parkinson’s can also improve memory in healthy people.

In one study, young volunteers were given either Alpha GPC or a placebo. Then researchers induced temporary amnesia by injecting them with scopolamine, an acetylcholine inhibitor. The volunteers that had taken the Alpha GPC scored significantly better on memory tasks than the control group.²¹

This result is not surprising, considering how important acetylcholine is for memory encoding.

There are also plenty of anecdotal reports of Alpha GPC improving recall. Some users report that this benefit starts kicking in after only a couple of weeks of supplementation.

Physical Performance Benefits Of Alpha GPC

While Alpha GPC has a reputation as a powerful nootropic supplement, it can also improve athletic performance and aid in recovery and muscle building after exercise.²²

Two separate studies found that Alpha GPC can increase explosive force production after supplementing for one week.

One study also noted an increase in “psychomotor vigilance,” meaning mind-body coordination. Interestingly, these studies only saw an improvement in lower body force, not in the upper body.

Still, both concluded that this supplement could be useful for strength and power athletes.²³²⁴

Alpha GPC For Bodybuilding

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As we mentioned, one of Alpha GPC’s major benefits include stimulating the production of growth hormone, which is vital for building new muscle.

There is also evidence that it can help burn fat as well.²⁵

For these reasons, many bodybuilders have added this supplement to their routine. If you live an active lifestyle, Alpha GPC could pull double duty for both mental and physical enhancement.

Alpha GPC For Studying

Alpha GPC could be a very useful study aid for many people due to its wide range of cognitive enhancements. One of the most classic and reliable nootropic stacks is Alpha GPC with a racetam (such as aniracetam or oxiracetam)

This combo is great for focus, attention, memory, and overall mental performance. We highly recommend looking into this stack if you are a student.

Does Alpha GPC Help With Depression?

So far there have not been any studies looking at this specifically.

Generally, depression is thought to affect neurotransmitters like dopamine and serotonin.

There is some preliminary evidence that Alpha GPC can increase dopamine levels, but this mechanism is not well understood.²⁶

Some users report that Alpha GPC can increase mood.

It may be the case that by improving brain function holistically, this nootropic could have a use for treating depression.

Since it affects ACh levels, Alpha GPC has a general effect on most mental processes.

However, more research is needed before we can draw any firm conclusions.

Is Alpha GPC Useful For ADHD?

There is no evidence that Alpha GPC can treat ADHD specifically. However, it does have cognitive benefits for memory that might have a secondary benefit for people with this condition.

It may be useful when stacked with other nootropics that are known to improve ADHD symptoms, such as NALT or l-tyrosine.

How Alpha-GPC Works In The Brain

what is alpha gpc,when to take alpha gpc,how to take alpha gpc,what does alpha gpc do,how long does alpha gpc take to work,how much alpha gpc to take,where to buy alpha gpc — Alpha GPC works through the acetylcholine system in the brain.

Alpha GPC is a highly bioavailable form of choline. Research shows that when it is ingested, it is quickly broken down into choline by the gut.²⁷

Blood concentrations of choline increase rapidly, and this spike helps it cross over into the brain. A dose of this nootropic can have effects for up to 30 hours.²⁸²⁹³⁰

Once Alpha GPC crosses the blood-brain barrier, it affects cognition through a few different pathways.

Alpha GPC is an acetylcholine (ACh) precursor.

ACh is one of the most pervasive chemical messengers in your brain. By increasing levels of ACh, you can increase the overall transmission of information throughout your brain. This affects most cognitive functions, from memory to mood, to decision making, to executive processing.

Alpha GPC and Phosphatidylcholine

Alpha GPC is also a precursor to a compound called Phosphatidylcholine (PC).

This is a phospholipid that makes up a significant proportion of your brain cells. PC is vital for maintaining and growing neurons.

Taking Alpha GPC means your body has enough choline circulating to build and repair cell walls with PC.

If your PC levels are too low, this can eventually lead to cognitive problems such as dementia or Alzheimer’s.

Alpha GPC and Your Nervous System

ACh isn’t just used by the brain, but by the whole nervous system which is why it may also help athletic performance.

Research shows it may increase output during resistance training and help recovery afterward. Higher levels of ACh also may increase growth hormone secretion, which can help with muscle growth.³¹³²

How Much Alpha-GPC Should I Take?

The recommended dose for most people is 400 mg three times a day.

When To Take Alpha GPC

Alpha GPC can be taken any time, although for some people it can have a mild stimulatory effect so it might be best to avoid it before bedtime. Most people take it in divided doses 2-3 times a day.

Can You Take Alpha GPC Every Day?

Alpha GPC is safe and non-toxic, and most people tolerate it well. You can most likely take it every day, but as with all nootropic supplements, we recommend cycling it.

This means sticking to a schedule where you take it on weekdays and not on the weekends or take a whole week off every couple of months. It’s important to listen to your body and discontinue any supplement you think may be causing issues.

Alpha-GPC Potential Side Effects

There are very few adverse reactions reported when taken 400mg 3x/day. Most clinical trials report that this nootropic has a very low side-effect profile.

However, some people report these Alpha-GPC Side effects:

Irritability
Low mood
Gastrointestinal issues
Headache

These are relatively rare, but discontinue use if you think it is cause problems for you.

There are no known drug interactions.

Alpha GPC Reddit Reviews

[su_quote cite=”u/Robtobin1″ url=”https://amp.reddit.com/r/Nootropics/comments/5jd3zr/alpha_gpc_caught_me_by_surprise/”]Alpha gpc is underrated imo when ppl say its optional to dose it alongside racetams for headache prevention. On its own it can really improve my workouts and motivation outside the gym. Alpha gpc and uridine are my fav mood enhancers. Dont even need tianeptine wheb i consistently take the mrhappystackk[/su_quote][su_quote cite=”u/Therealbigjon” url=”https://www.reddit.com/r/Nootropics/comments/5jd3zr/alpha_gpc_caught_me_by_surprise/?utm_source=amp&utm_medium=&utm_content=comments_view_all”]I take 300 mg twice a day. Sometimes on weekends I forget to take it and my wife is convinced that it effects my mood. She says I seem happier when I take it.[/su_quote][su_quote cite=”u/reaper59″ url=”https://www.reddit.com/r/Nootropics/comments/1l4it7/alpha_gpc_success/?utm_source=amp&utm_medium=&utm_content=post_body”]The alpha gpc is absolutely awesome. I must have been deprived of choline because before I was groggy all day and had some low level of brain fog. I’ve just been taking the alpha gpc, l theanine, b complex, multi, and fish oil and I have been feeling absolutely great. My lifts at the gym have more energy, I can focus more easily, and I find I even have more motivation.[/su_quote]

Alpha GPC Amazon Reviews

[su_quote cite=”Volbriecht Ortrun Solvein” url=”https://www.amazon.com/gp/aw/reviews/B00XWQSD7G/ref=cm_cr_unknown?ie=UTF8&filterByStar=five_star&pageNumber=1″]I find Alpha GPC Choline to be absolutely amazing both my wife and myself use it daily. We started using it in small doses and the improvement in focus and memory is clear. We then up our doses to eight caps a day and well that did not disappoint it just improved even more. [/su_quote][su_quote cite=”Thomas Croyle” url=”https://www.amazon.com/gp/aw/reviews/B00XWQSD7G/ref=cm_cr_unknown?ie=UTF8&filterByStar=five_star&pageNumber=1″]Previous to taking Alpha GPC, I was becoming very forgetful, and I felt that my strength was fading. After taking the supplement for several weeks, I noticed my cognitive function improving, and my strength improved as well. I am very pleased with this supplement.[/su_quote][su_quote cite=”Skipppy” url=”https://www.amazon.com/gp/aw/reviews/B00XWQSD7G/ref=cm_cr_unknown?ie=UTF8&filterByStar=five_star&pageNumber=1″]Foggy head & fatigue if I take a full dose in the morning, but clear and focused if I spread it out 1/2 morning 1/2 evening.. highly recommend – Good Stuff![/su_quote]