Oxiracetam: Benefits, Dosing, Where To Buy, And More!

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Key Information

Oxiracetam is a synthetic nootropic:

Oxiracetam is a derivative of piracetam that has more potent and diverse cognitive benefits.

Oxiracetam enhances memory and learning:

Oxiracetam modulates AMPA and NMDA receptors, increases neurotransmitter release, and boosts brain metabolism.

Oxiracetam may prevent cognitive decline:

Oxiracetam has neuroprotective effects and can improve cognitive function in patients with dementia or brain damage.

Oxiracetam is safe and well-tolerated:

Oxiracetam has few side effects and can be taken with a choline source to prevent headaches.

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In the ever-expanding world of nootropics, Oxiracetam stands out as a promising cognitive enhancer with a range of potential benefits for mental performance and brain health.

As part of the racetam family, Oxiracetam has gained attention for its ability to improve memory, focus, and overall cognitive function.

At Holisticnootropics.com, we believe in taking a holistic approach to cognitive enhancement, combining evidence-based supplementation with lifestyle practices that support overall mind-body health.

In this comprehensive guide, we’ll explore the science behind Oxiracetam, its benefits, dosage, safety, and how it fits into a holistic nootropic regimen.

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How Does Oxiracetam Work?

Oxiracetam’s mechanism of action involves modulating key neurotransmitter systems in the brain, particularly glutamate and acetylcholine. Oxiracetam can enhance cognitive processes such as memory formation, learning, and focus by influencing these neurotransmitters. Here are some key ways Oxiracetam works:

  • Modulates AMPA and NMDA receptors, which are involved in glutamate signaling and synaptic plasticity
  • Increases acetylcholine release and enhances the activity of choline acetyltransferase (ChAT), an enzyme crucial for acetylcholine synthesis
  • Boosts glucose and oxygen consumption in the brain, supporting energy metabolism and cognitive function

By optimizing these neurotransmitter systems, Oxiracetam can help improve various aspects of cognitive performance, making it an attractive option for those seeking a mental edge.

Benefits of Oxiracetam

Oxiracetam offers a range of potential cognitive benefits backed by scientific research and user anecdotal reports. Some of the key benefits include:

  • Cognitive enhancement: Oxiracetam can improve memory, learning, focus, and mental clarity. It may help with tasks that require sustained attention and cognitive processing.
  • Neuroprotection: Studies suggest that Oxiracetam may have neuroprotective properties, potentially helping to slow age-related cognitive decline and support brain health in conditions like Alzheimer’s and dementia.
  • Mood and emotional well-being: Some users report that Oxiracetam can help reduce anxiety and depression symptoms while boosting motivation and drive.

While more research is needed to fully understand the extent of Oxiracetam’s benefits, the available evidence suggests that it can be a valuable tool for optimizing cognitive performance and supporting long-term brain health.

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Oxiracetam Dosage

Finding the right Oxiracetam dosage is essential for maximizing its benefits while minimizing the risk of side effects. The recommended dosage range for Oxiracetam is typically between 800-2400 mg per day, divided into two or three doses. However, factors such as body weight, tolerance, and desired effects can influence the optimal dosage.

It’s best to begin with a lower dose and gradually increase it as needed when starting with Oxiracetam. This approach allows you to assess your response and find the best dosage for you. It’s also important to consider the timing of your doses, as taking Oxiracetam too late in the day may lead to insomnia or sleep disturbances.

Oxiracetam Side Effects and Safety

Oxiracetam is generally well-tolerated, with a low incidence of side effects. However, some users may experience the following:

  • Headache
  • Insomnia
  • Irritability
  • Digestive discomfort

These side effects are usually mild and transient, resolving independently with continued use or dosage adjustment. Rare side effects may include allergic reactions or skin rashes. If you experience any severe or persistent side effects, discontinue use and consult a healthcare professional.

Oxiracetam is considered safe for long-term use, with no evidence of toxicity or serious adverse effects in studies. However, using Oxiracetam responsibly and not exceeding the recommended dosage is essential. If you have any pre-existing medical conditions or are taking medications, consult your doctor before starting Oxiracetam to ensure it’s safe for you.

Oxiracetam Stacks

Oxiracetam can be taken alone or combined with other nootropics for synergistic effects. Some popular Oxiracetam stacks include:

  • Oxiracetam + Choline source (Alpha-GPC or CDP-Choline): Adding a choline supplement can help prevent headaches and enhance the cholinergic effects of Oxiracetam.
  • Oxiracetam + Piracetam or Aniracetam: Combining Oxiracetam with other racetams may provide a broader spectrum of cognitive benefits.

Learn More: Best Nootropic Stack For Ultimate Brain Performance

When creating an Oxiracetam stack, it’s essential to consider your individual goals, tolerance, and response. Start with lower doses of each component and adjust as needed to find the optimal combination for your needs.

Oxiracetam vs. Other Racetams

Oxiracetam is just one of many racetam nootropics, each with its own unique profile of effects. Here’s a comparison of Oxiracetam with some other popular racetams:

RacetamPotencyHalf-lifeUnique Effects
OxiracetamMedium8 hoursStimulant-like, verbal fluency
PiracetamLow5 hoursMild cognitive enhancement
AniracetamMedium1-2 hoursAnxiolytic, creativity boost
PramiracetamHigh4-6 hoursIntense focus, memory improvement

While all racetams share some similarities in their mechanism of action, each has its own unique effects and benefits. Oxiracetam is known for its stimulant-like properties and potential to enhance verbal fluency, setting it apart from other racetams. When choosing a racetam, consider your specific goals and how each aligns with your needs.

Where to Buy Oxiracetam

When purchasing Oxiracetam, it’s crucial to choose a reputable vendor that prioritizes quality, purity, and safety. Some trusted vendors in the nootropics community include:

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Look for vendors that provide third-party testing results and have a track record of delivering high-quality products. Be aware of the legal status of Oxiracetam in your country, as it may be regulated or restricted in certain jurisdictions.

Oxiracetam Discussions on Reddit

User Experiences and Anecdotes

Reddit is a valuable resource for learning about personal experiences with Oxiracetam. Many users report positive effects, such as increased focus, mental clarity, and improved verbal fluency.

“Oxiracetam definitely felt like a stimulant to me… Similar to any other racetam but not much unique flavor, kind of like piracetam.”

u/illenial999 in discussion ‘Is oxiracetam available anywhere?’

However, some users also report side effects or concerns, such as headaches or insomnia, highlighting the importance of individual variation in response to Oxiracetam.

Dosage and Administration Tips

Reddit discussions often revolve around finding the optimal Oxiracetam dosage and timing for best results. Many users suggest starting with lower doses and adjusting based on personal responses.

“I’m quite sensitive to oxiracetam for some reason and take much less than the average dose. Was mixing about 100-300mg of oxiracetam with some coffee for a while.”

u/xdiggertree in discussion ‘Oxiracetam and Aniracetam’

Some users also discuss the importance of timing doses properly, such as taking Oxiracetam earlier in the day to avoid sleep disturbances.

Stacking and Synergy

Oxiracetam is often combined with other nootropics for enhanced effects. Reddit users share their experiences with various Oxiracetam stacks and the synergy they’ve found.

“Personally I loved OxiR for the cognitive aspect, stacked with a good SkullCap for anxiolytic really made work a lot better IME.”

u/xdiggertree in discussion ‘Oxiracetam and Aniracetam’

These discussions provide valuable insights into how Oxiracetam can be combined with other supplements for a more tailored and effective nootropic regimen.

FAQ about Oxiracetam


Oxiracetam is a promising nootropic with a range of potential cognitive benefits, from improved memory and focus to enhanced verbal fluency and neuroprotection.

As part of a holistic approach to cognitive enhancement, Oxiracetam can be a valuable addition to a well-rounded nootropic regimen. By understanding its mechanism of action, benefits, dosage, and safety profile, you can decide whether Oxiracetam is right for you.

However, it’s essential to remember that nootropics are just one piece of the puzzle when it comes to optimizing brain health and performance. At Holisticnootropics.com, we believe in a comprehensive approach encompassing nutrition, exercise, sleep, stress management, and other lifestyle factors.

Combining evidence-based supplementation with healthy habits can unlock your brain’s full potential and achieve lasting cognitive benefits.

As with any new supplement, it’s crucial to do your own research, consult with a healthcare professional, and start with lower doses to assess your individual response. By taking a responsible and informed approach to Oxiracetam and other nootropics, you can harness their potential to support your cognitive goals and overall well-being.

We hope this comprehensive guide has provided valuable insights into Oxiracetam and how it can fit into your holistic nootropic journey. If you have any personal experiences, questions, or insights, we encourage you to join the discussion in the comments section below.

Together, we can continue to explore the fascinating world of nootropics and support each other in our quest for optimal brain health and performance.


  1. Copani A, et al. Nootropic drugs positively modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-sensitive glutamate receptors in neuronal cultures. J Neurochem. 1992;58(4):1199-204. doi: 10.1111/j.1471-4159.1992.tb11336.x. https://pubmed.ncbi.nlm.nih.gov/1372342/
  2. Mochizuki D, et al. [Biochemical studies of oxiracetam (CT-848) on cholinergic neurons]. Nihon Yakurigaku Zasshi. 1992;99(1):27-35. Japanese. doi: 10.1254/fpj.99.27. https://pubmed.ncbi.nlm.nih.gov/1559639/
  3. Gabryel B, et al. Influence of piracetam and oxiracetam on the content of high-energy phosphates and morphometry of astrocytes in vitro. Pol J Pharmacol. 1999;51(6):485-95. https://pubmed.ncbi.nlm.nih.gov/10817522/
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Erik Abramowitz is a certified Nutritional Therapy Practitioner (NTP), Naturopathic Doctoral student, health coach, and father. He is the primary content creator for HolisticNootropics.com and the host of the Holistic Nootropics Podcast.