Having been a nutritional therapist for several years now, I’ve seen firsthand the amazing potential of nootropics to help my clients maximize their brain performance.
After spending countless hours researching and testing different nootropics, I have crafted an incredibly powerful list of products that can help improve focus, memory, creativity and energy levels — just to name a few. And each product has been carefully selected for its cost-effectiveness, ingredients, and reviews.
By reading this article, you’ll get an in-depth look at the concept of nootropics stacks, become familiar with more popular preformulated stacks, and you’ll have some insight into what makes the best nootropic stack. So let’s dive in.
Biohack Your Brainpower
Best Preformulated Nootropics Stacks April 2024 – Quick Answers
Mind Lab Pro
NooCube
Alpha Brain by Onnit
Dopamine Brain Food by Natural Stacks
Serotonin Brain Food by Natural Stacks
Preformulated Nootropic Stacks FAQ
As nootropics become more popular, so too do nootropic stacks.
This idea of mixing and matching different nootropic supplements, also known as stacking, is one of the most effective ways to boost brain performance significantly.
Stacking goes beyond the idea that if something is good, more must be better, as it utilizes the synergistic power that two (or more) compounds can elicit from each other.
In other words, 1 + 1 = 5!
Nootropic Stacks vs. Individual Nootropic Supplements
Nootropic brain supplements are smart drugs that have various actions on brain functioning.
They can enhance learning, boost memory, and improve natural mental performance.1Noor Azuin Suliman et al, Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural NootropicEvid Based Complement Alternat Med. 2016
Nootropics can also help the brain and body to resist stress conditions such as low oxygen or electroconvulsive shock.2Noor Azuin Suliman et al, Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural NootropicEvid Based Complement Alternat Med. 2016
Nootropics may also protect the brain from damage by physical and chemical toxins. 3Amy L. Roe et al, The Safety and Efficacy of Botanicals with Nootropic EffectsCurr Neuropharmacol. 2021
All these functions vary depending on the formulation of a nootropic supplement and its main ingredient.
Nootropic Stacks
On the other hand, a nootropic stack is formed by the combination of various nootropic supplements together.
All the components of a nootropic stack should act synergistically, enhancing and augmenting the effect of each other.4Ruchi Malik et al Towards better brain management: nootropicsCurr Med Chem. 2007
Most importantly, a nootropic stack should be safe.
When properly formulated, a nootropic stack can significantly enhance overall brain performance.
A suitable formulation of nootropic ingredients presents many cognitive benefits that boost memory, brain energy, mental processing speed, and memory and retention skills.
The right stack consisting of brain supplements, including the best nootropics, may also stave off cognitive decline, promoting an overall healthy brain.
Nootropic Synergy – Mixing Nootropics
The best nootropic stack for your needs includes nootropic ingredients that work synergystically to maximize their effectiveness.
Although tempting, throwing the kitchen sink of even the best nootropic supplements in a formula is not wise as you may encounter adverse effects.
When used together, many nootropic supplements biochemically antagonize each other, cancel out their effect, and lead to zero benefits.
That’s why it’s important to carefully do your research and make sure you understand how to pair each nootropic supplement.
The Best Nootropic Stacks Understand Timing
Every supplement has a half-life in the body, meaning a specific time after which the amount will reduce to half.
Stacks are devised to act effectively, keeping timing and half-life in mind. This is true even for agonists.
Using too many synergistically acting nootropics in a stack might lead to a worse outcome than an expected good one simply due to half-life complications and other biochemical factors.
Excessive use may have zero to abnormally large effects on the body.
Always try supplementing lower dosages first and give enough time to observe their effects.
You can adjust the dosage slightly if you feel the body needs more.
Make sure to avoid overdosing on nootropics alongside other powerful nootropics because you don’t know what the outcome would be in that case.
Nootropics and Brain Health
Nootropics have many cognitive benefits that contribute to overall powerful, healthy brain. An effective nootropic stack increases these benefits exponentially.
Nootropic stacks, loaded with potent cognitive enhancers, encourage the release of brain chemicals escalating brain energy and mental function.5Noor Azuin Suliman et al, Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural NootropicEvid Based Complement Alternat Med. 2016
Nootropic stacks have also been shown to promote the growth of brain cells, and strenghtening brain cell membranes, henceforth preventing brain degeneration and promoting brain cell repair and brain health.6Philippe Taupin, Nootropic agents stimulate neurogenesis. Brain Cells, Inc.: WO2007104035Expert Opin Ther Pat. 2009
A good nootropic stack helps you reach peak mental performance and brain power preventing brain degeneration.
Nootropic Stack Benefits
Nootropic stacks can improve brain function in many ways, and are used for everything from focus and memory improvement, to boosts in mental processing and overall mental clarity.7María Medrano et al Acute Effect of a Dietary Multi-Ingredient Nootropic as a Cognitive Enhancer in Young Healthy Adults: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover TrialFront Nutr. 2022
Many preformulated nootropic stacks like Mind Lab Pro and the Alpha Brain nootropic stack contain a range of natural nootropic supplements, each with their own set of benefits.
These nootropics can increase the blood flow to the brain, which boosts memory, mental processing speed, and cognitive performance. 8María Medrano et al Acute Effect of a Dietary Multi-Ingredient Nootropic as a Cognitive Enhancer in Young Healthy Adults: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover TrialFront Nutr. 2022
This helps individuals who have to retain a lot of new information daily, including high performing professionals, students, and even athletes.
Daily use can make learning and productivity more fruitful because the brain is more open to accepting and processing new information.
Nootropic stacks have also been shown to improve mental energy.9Noor Azuin Suliman et al, Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural NootropicEvid Based Complement Alternat Med. 2016
This sharpens the focus and improves brain health and performance.10Noor Azuin Suliman et al, Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural NootropicEvid Based Complement Alternat Med. 2016
Thus an individual is better able to focus on studies and routine tasks. An increase in concentration is likely to improve the quality of work.
What To Look For In A Nootropic Stack
A nootropic stack should be composed of an amalgam of ingredients acting in synergy.
It should contain a good blend of natural ingredients including a mix of nootropic supplements, herbs, adaptogens, mushrooms, amino acids, vitamins, minerals, and as few added ingredients as possible.
The best nootropic stack should consist of a proportion of cofactors for cellular processes such as magnesium, zinc, and B vitamins.
Those making their own personal nootropic stack may opt for stacking smart drugs and synthetic nootropic supplements like racetams and noopept. We discuss some strategies for those below.
You also want to look for substances that mitigate or inhibit ingredient side effects.
Using l-theanine with caffeine is an example of this as l-theanine can take the edge off and lower the stimulatory effects.
Caffeine
Caffeine, when used in moderate doses along with other suitable nootropic supplements, can prove to be a beneficial nootropic.
Caffeine stacked with L-theanine is used as a beginner nootropic supplement.
It enhances cognitive functioning and learning.11Bryant J.Jongkees et al, Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands—A reviewJournal of Psychiatric Research. 2015
Caffeine is one of the most predominant names in energy boosting. It increases mental alertness and brain function.12Bryant J.Jongkees et al, Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands—A reviewJournal of Psychiatric Research. 2015
A few milligrams of this brain supplement is enough to increase mental clarity, cognitive functioning, and cognitive energy13Jorge Gutiérrez-Hellín and David Varillas-Delgado, Energy Drinks and Sports Performance, Cardiovascular Risk, and Genetic Associations; Future ProspectsNutrients 2021
Proprietary Blends
A proprietary blend is a special combination of ingredients in a nutritional supplement that is designed for a particular function.
Like a secret recipe, the amounts and ratios of the custom blend components are considered a trade secret.
Proprietary blends are looked down on because you can’t quantify how much of each ingredient is included.
This is not necessarily bad, but something to keep in mind.
As nootropic supplements have a crucial role in overall brain health, the blend can not be something to solely rely on as you don’t know what could be the effect of the amount of each component in a blend.
Best Overall Nootropic Stack [Display_current_date]
Following are some of the overall best nootropic stack products for healthy brain function.
Mind Lab Pro
Designed to optimize cognitive functions through 11 natural ingredients that work in 6 bio-pathways
Boosts serotonin levels which can help improve your mood, sleep quality, appetite control, stress management,
Mind Lab Pro helps improve focus, memory, clarity, energy levels without relying on stimulants or artificial additives
Contains premium forms of each ingredient for enhanced potency and activity, while avoiding potential side effects associated with lower quality ingredients
Mind Lab Pro aims to provide an all-in-one solution for improving mental health & performance without any harsh side effects like those associated with prescription medications or other supplements on the market today.
It contains 11 clinically studied ingredients that work synergistically to improve focus, memory, clarity, and energy levels. For example, Rhodiola Rosea helps reduce fatigue, while Citicoline increases alertness and concentration. Phosphatidylserine helps protect neurons from damage, while L-Theanine helps reduce stress and anxiety.
In addition to these ingredients, Mind Lab Pro also contains Lion’s Mane Mushroom, which has been shown to stimulate Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). These proteins are important for developing new neurons in the brain and releasing neurotransmitters such as dopamine, which can help improve mood and focus.
Mind Lab Pro has been developed to affect the following six key bio-pathways:
- Neuro-Energy Metabolism
- Antioxidant Enhancements
- Neurotransmitter Support
- Neural Structures Protection
- Stress/Anxiety Resistance
- Brain Circulation/Oxygenation
The recommended dosage is two capsules daily in the morning or early afternoon. You can safely increase your dose to four capsules daily during increased cognitive demand. Taking Mind Lab Pro with water, juice, or coffee is best.
I’ve been using Mind Lab Pro for several extended periods of high-demand brain activity, and I can confidently say that it lives up to its claims.
If you are looking for a natural supplement to help boost your cognitive performance, then Mind Lab Pro is an excellent choice to get the most out of your day and start building toward long-term cognitive performance.
Pros
- Proven to boost overall cognitive performance including memory, focus, mood, creativity, motivation, and overall well-being.
- Potent blend of all-natural nootropics, herbs, amino acids, vitamins, and minerals.
- Good for experienced biohackers and those new to nootropics.
- Caffeine Free
- No artificial fillers or toxic preservatives
- Affordable Price, money back guarantee
Cons
- Ingredients are lower dosed.
NooCube
Improves oxygenation, nutrient absorption and stimulate neurotransmitter production for better cognitive function
Stimulates the production of neurotransmitters
Supports increases in concentration, learning, short-term memory, and problem-solving
Reduce age-related cognitive decline while improving overall mental performance
NooCube is a revolutionary dietary supplement that provides cognitive benefits to help people with their everyday tasks.
It contains a unique blend of natural ingredients such as Lutemax, Bacopa monnieri, Huperzia Serrata, Pterostilbene, Resveratrol, L-theanine, L-tyrosine, Alpha GPC, Oat straw extract, Cat’s claw, Vitamin B1, Vitamin B7, and Vitamin B12.
Lutemax is derived from lutein and zeaxanthin and helps support optimal health by helping the body absorb light better. Bacopa monnieri helps boost memory and concentration by supporting neurotransmitters in the brain.
Huperzia Serrata boosts mental clarity by making it easier for your brain to process information quickly and accurately. Pterostilbene helps preserve healthy brain cells, while Resveratrol promotes overall brain health.
L-theanine works in combination with caffeine to provide more focused alertness without the jittery side effects generally associated with the caffeine alone.
L-Tyrosine aids in reducing mental fatigue, while alpha GPC helps improve memory formation after exercise or physical stress. Oat straw extract helps increase mental energy levels while cat’s claw supports cognitive function through its anti-inflammatory properties. Vitamins B1 (thiamin), B7 (biotin), and B12 (cobalamin) support healthy nervous system functioning crucial for all aspects of neural communication within the brain.
NooCube combines this unique blend of natural ingredients to create an effective solution for people looking to boost their focus and concentration when performing daily tasks or studying for exams or projects.
By providing improved cognitive abilities without the dangerous side effects of other prescription drugs, NooCube is an easy alternative for anyone looking to get ahead in life without risking their long-term health or productivity levels.
As someone who has used NooCube regularly, I can confidently say that it has made an incredible difference in my day-to-day life since taking it regularly over the past few months.
The combination of natural ingredients has allowed me to focus on my tasks throughout the day while providing increased energy levels so I can stay productive longer into the night if needed.
Overall I think NooCube is one of the best supplements out there right now – allowing people to boost their cognitive abilities safely and naturally – which is why I highly recommend it.
Pros
- Preformulated for easy access to essential nootropics
- Best value for nootropic cognitive enhancement
- All-natural ingredients with no fillers/preservatives
- Includes B-vitamins for enhanced metabolism
Cons
- Some ingredients may be underdosed for specific nootropic therapy
NITROvit
Improves Memory Formation & Recall : contains Vitamin B12 which has been shown to improve memory formation and recall by increasing levels of acetylcholine in the brain.
Accelerates learning: The combination of Noopept® and Choline helps to increase mental clarity, focus, concentration, and overall cognitive performance.
Provides instant energy & focus without caffeine
Nitrovit is a nootropic supplement designed to support healthy cognitive function and enhance mental performance. It contains a powerful mix of natural ingredients, including Noopept, which makes it stand out from other nootropic supplements on the market.
Noopept is an advanced cognitive enhancer that has been demonstrated to help improve memory, reduce anxiety and protect neurological health. It works by increasing levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which are essential for maintaining healthy brain function and supporting the formation of new neurons. Noopept also helps to prevent oxidative stress and lipid peroxidation in the brain, which can lead to age-related cognitive decline.
Unlike most other racetams, Noopept has a unique structure that allows it to cross through the blood-brain barrier much more easily than other racetams, resulting in faster absorption and a greater impact on cognitive functioning. It is also much more potent than other racetams; just one dose of Noopept can be as effective as several doses of piracetam or oxiracetam.
Nitrovit is one of the few supplements on the market that includes Noopept in its formula.
We like that it combines noopept with herbal extracts and essential vitamins that help the body more fully utilize the ingredients. NITROvit combines Vitamin B12 with Noopept®, and Choline – all proven to be effective in improving cognitive function. Other ingredients include Huperzine A, Vinpocetine, Alpha GPC, L-Theanine, Acetyl L-Carnitine and GABA. Each of these components provides different benefits to help boost your cognitive performance:
- Huperzine A helps boost cognitive function and enhances mental clarity
- Vinpocetine improves blood flow to the brain for an oxygen-rich environment for optimal mental performance
- Alpha GPC supports mental energy production and helps regulate overall cognitive functioning
- L-Theanine boosts mental health by decreasing anxieties and stress related to cognitive tasks
- Acetyl L-Carnitine supports mental alertness, focus, and clarity of thought
- GABA regulates the nervous system and improve nerve impulse transmission
Key benefits of NITROvit®:
- Improves Memory Formation & Recall: NITROvit® contains Vitamin B12 which has been shown to improve memory formation and recall by increasing levels of acetylcholine in the brain.
- Accelerates Learning: The combination of Noopept® and Choline helps to increase mental clarity, focus, concentration, and overall cognitive performance.
- Provides Instant Energy & Focus: The combination of ingredients helps to give you an instant boost of energy and focus when you need it most.
- Helps with Insomnia & Infantile Spasms: Nitrovit has been shown to be effective in treating insomnia as well as infantile spasms due to its calming effects on the brain.
While not as effective as Mind Lab Pro or in our experience, then NITROvit® is still a solid choice for those looking for a nootropic stack without having to mix your own supplements.
Alpha Brain by Onnit
Alpha Brain delivers a blend of potent nootropics that promote alpha brain waves and improved cognitive function
The formula includes L-Theanine, phosphatidylserine, L-tyrosine, cats claw, be it in a propriety form
There are no artificial additives, flavors, sweeteners, colors, caffeine, dairy or gluten in the product
Keto and paleo diet friendly
Alpha Brain is a nootropic supplement created by Joe Rogan’s well-known supplement company Onnit. As such, its probably the most hyped, most heavily marketed nootropic stack on the planet.
We like Alpha Brain because not only does it provide natural ingredients to help boost cognitive enhancement but it also offers many other benefits such as improved brain energy levels and enhanced concentration skills; plus its easy-to-take capsules make taking it on a daily basis simple! On the other hand, some people may not be fans of Alpha Brain due to its proprietary blends since those looking for full transparency may not be satisfied with what they see on the label.
I personally have tried out Alpha Brain and noticed huge improvements in my focus levels after a few weeks of consistent usage; this allowed me to power through difficult tasks with much more ease than before taking it.
Alpha Brain was designed to enhance cognitive functions, such as focus, concentration, and memory. It contains various natural ingredients that have been carefully selected in order to give the optimal boost for peak mental performance.
The primary ingredient in Alpha Brain is Alpha GPC or Alpha glycerylphosphorylcholine. This is a choline-enhancing compound that helps to replenish the neurotransmitter acetylcholine, which aids in memory formation and recall. Another beneficial ingredient is Huperzia Serrata, an extract from Chinese club moss which has been used for centuries for its cognitive-enhancing properties.
Bacopa Monnieri, another key ingredient found in Alpha Brain, has been clinically proven to improve memory retention and comprehension. L-Theanine and L-Tyrosine are amino acids that help increase alertness and reduce stress.
Oat Straw Extract, Phosphatidylserine, Cat’s Claw Extract (AC-11), Pterostilbene, and L-Leucine are all additional ingredients found in Alpha Brain that aid in improving mental clarity and focus while maintaining overall brain health.
Finally, Vitamin B6 promotes energy production throughout the body while helping to prevent fatigue caused by extended periods of concentration or mental strain.
It is recommended to take two capsules of Alpha Brain daily after a light meal for optimal results.
However, it can take up to several weeks before you begin feeling any noticeable effects depending on your individual circumstances so patience is key when trying this supplement out for the first time.
Neurofuel
Reduces stress and fatigue
Boosts neurotransmitter cyclic adenosine monophosphate (cAMP) levels, leading to improved focus and concentration
Helps regulate hormones important for learning and memory formation
Contains B6, artichoke extract, forskolin, L-phenylalanine and acetyl-L-carnitine
NeuroFuel is a brain supplement and focus supplement created by Natural Stacks. NeuroFuel contains the patented CILTEP Nootropic Formula that put the company on the map and set the standard for high-quality nootropic stacks long ago, and its this unique formula of natural ingredients sets Neurofuel apart from other supplements:
It contains B6, artichoke extract, forskolin, L-phenylalanine and acetyl-L-carnitine, all of which work together to increase neurotransmitter cyclic adenosine monophosphate (cAMP) levels in the brain which helps to improve focus and concentration, as well as memory formation and recall.
Together these ingredients create an effective nootropic stack that can help you reach peak mental performance.
What we really like about NeuroFuel is the company behind it – Natural Stacks is committed to providing clean and effective supplements backed by science. They have an “open source” transparency program that provides ingredient traceability and 3rd party lab test results for every batch so that you can make informed decisions about their health and wellness.
I have personally used Neurofuel for a few months, and I can attest to its effectiveness in improving my mental clarity and focus. After taking it regularly, I noticed an increase in my ability to concentrate on tasks for more extended periods of time without feeling overwhelmed or fatigued.
The dosage instructions were easy to follow, and the capsules are easy to take on an empty stomach in the morning for maximum effect.
Serotonin Brain Food by Natural Stacks
Contains Rhodiola Rosea and four key ingredients to help the body produce serotonin
Supports serotonin production to help maintain a positive mood
Offered in an open source format for customers to know exactly what is in the product
Offered in an open source format for customers to know exactly what is in the product
Are you feeling overwhelmed, unmotivated, and anxious? You may be suffering from low levels of serotonin. Serotonin is a neurotransmitter the human brain produces that helps regulate mood, sleep, and appetite. Low serotonin can lead to feelings of sadness, cravings for sweets or starchy food, fatigue, and anxiety.
Natural Stacks has the perfect solution for those experiencing these symptoms: Serotonin Brain Food. This all-natural supplement contains the essential ingredients to help your body produce more serotonin. Its four key ingredients are L-Tryptophan, Vitamin B3, Magnesium Glycinate & Zinc Glycinate, which work together to create balanced serotonin levels in your body and give you back control of your life. Plus, Rhodiola Rosea helps boost energy levels and improve mental clarity. Natural Stacks guarantees 100% satisfaction with their product, so customers have nothing to worry about when using it.
I’ve been using this supplement for several weeks now, and I feel great! I’m no longer plagued by overwhelming fatigue, and my mood has improved significantly.
The days that used to be filled with stress are now far less anxious thanks to the balanced serotonin levels provided by Natural Stack’s Serotonin Brain Food.
I feel energetic during the day with improved concentration and better focus, enabling me to get more done each day than ever before! It’s incredible how much a balanced diet can play in improving overall well-being and this supplement is an essential part of that routine.
Dopamine Brain Food by Natural Stacks
Improved focus and attention
Increased drive to accomplish tasks
Better physical and athletic balance
Reduced brain fog and improved mental clarity
Contains natural ingredients like Vitamin C, Vitamin B6, and L-Tyrosine
Dopamine Brain Food by Natural Stacks is a great nootropic stack that has helped us out quite a bit! It’s designed to support the production of dopamine, an essential neurotransmitter for the central nervous system.
As one of the primary chemical messengers in the brain, dopamine plays a vital role in regulating our emotions, attention, and focus. It also helps reinforce certain behaviors and provides an intense feeling of reward and pleasure. Low dopamine levels can lead to difficulty concentrating, depression, and fatigue, so keeping our dopamine levels balanced for optimal mental health and well-being is essential.
This supplement combines vitamins and minerals to help focus, concentration, and mental clarity. The ingredients in Dopamine Brain Food are Vitamin C, B6, Rhodiola Rosea extract, L-Tyrosine, and Ginkgo Biloba extract. Vitamin C helps with cognitive function and healthy brain development. Vitamin B6 boosts energy metabolism and lifts your mood. Rhodiola Rosea extract is an adaptogen that helps reduce stress and fatigue while improving mental performance. L-Tyrosine aids in producing dopamine in the brain, which improves alertness, while Ginkgo Biloba extract has been used for centuries to improve memory and cognitive function.
We’ve taken this supplement and can confirm it has positively affected cognitive performance. After taking this supplement for a few weeks, we noticed increased focus levels and improved mental clarity. Our experience has been great – we recommend Dopamine Brain Food by Natural Stacks if you want something to boost your cognitive performance!
DIY Nootropic Stacks
It’s essential to keep a few things in mind if you’re combining nootropics to form your own nootropics stack, primarily the synergy and complementary mechanism of each ingredient in the stack.
As mentioned above, just combining the best nootropic supplements can only get you so far.
A nootropics stack is more than just a bunch of ingredients. It’s a mutually beneficial relationship between multiple nootropic supplements.
Synergy between nootropic suppelements specifically means that adding two or more nootropics may not be equal to the actual numerical sum of the components but may result in a greater than anticipated effect.14Kyle R. Roell, An Introduction to Terminology and Methodology of Chemical Synergy—Perspectives from Across DisciplinesFront. Pharmacol., 2017
That’s 0 plus 0 may be equal to 1, or 1 plus 1 may be equal to 4.
You cannot stack nootropics that do not complement each other and act synergistically.15Kyle R. Roell, An Introduction to Terminology and Methodology of Chemical Synergy—Perspectives from Across DisciplinesFront. Pharmacol., 2017
If each ingredient behaves differently or oppositely, then using them in a stack would be useless.16Kyle R. Roell, An Introduction to Terminology and Methodology of Chemical Synergy—Perspectives from Across DisciplinesFront. Pharmacol., 2017
Also keep in mind that not all stacks work for everyone.
Everyone’s brain reacts differently to different chemicals; therefore, it is essential to make a formulation that works for you.17Kyle R. Roell, An Introduction to Terminology and Methodology of Chemical Synergy—Perspectives from Across DisciplinesFront. Pharmacol., 2017
Many companies like Thesis make a customized nootropic according to every individual’s specific needs.
Stacks can also be made for a particular purpose. Like there can be a stack for the whole day.
Another stack may be specific for night or day, depending on your daily activities.
A stack may also be suitable to be used before exercise or studying to increase the outcomes of the activity.18Kyle R. Roell, An Introduction to Terminology and Methodology of Chemical Synergy—Perspectives from Across DisciplinesFront. Pharmacol., 2017
Since specific stacks may not work for everyone as everyone reacts differently to different substances, it is necessary to always check with a trained professional before making any changes to the diet and supplement regimen.19Kyle R. Roell, An Introduction to Terminology and Methodology of Chemical Synergy—Perspectives from Across DisciplinesFront. Pharmacol., 2017
Best Nootropic Starter Stack
The most basic starter stack of nootropics is the combination of caffeine and L-Theanine, which act in synergy to augment energy and focus.
L-theanine’s main cognitive benefit is to promote alpha brain waves promotes the feeling of
“being in the zone” and calming the anxious mind.
These two benefits bolster caffeine’s ability to increase mental alertness and reduce brain fog with more focused mental energy.
Overall, this stack helps in increasing mental clarity and alertness, and mental clarity.
Racetam Stacks
Racetam stacks involve the combination of a choline source and a racetam.
Piracetam (racetam) supplements have a lot of significant advantages for brain function, but they must be taken in substantial doses and in combination with a choline source to work.20Noor Azuin Suliman et al, Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural NootropicEvid Based Complement Alternat Med. 2016
This is because racetams work to deplete choline stores.
Always use choline like alpha gpc or cdp choline or huperzine A while taking racetams to counter this negative effect..21Noor Azuin Suliman et al, Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural NootropicEvid Based Complement Alternat Med. 2016
Racetams include piracetam, oxiracetam, phenylpiracetam and aniracetam.
These stacks have many benefits. They have long been known to prevent cognitive decline.
They have several impacts, including enhancing memory and learning ability, enhancing attention span, focus, and concentration, and even assisting in mood enhancement.22Noor Azuin Suliman et al, Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural NootropicEvid Based Complement Alternat Med. 2016
Best Stack For Learning and Memory
Some of the best nootropic stacks for boosting learning and memory include the following ingredients:
L-Tyrosine
This ingredient assists in stress reduction, relieving anxiety, and improving mood.
It can improve cognitive function, thus maintaining cognitive performance even under extreme stress.
Tyrosine helps steady cognitive performance during acute stress and boosts mental function and blood flow.23Zizhen Xie et al, A review of sleep disorders and melatoninNeurol Res. 2017
Lion’s Mane
Lions Mane Mushroom has been used to support nerve growth factor in the human brain.
It has a neuroprotective role in neurodegenerative diseases by virtue of its composition of a large amount of structurally different bioactive components, including polysaccharides, erinacines, hericerins, steroids, alkaloids, and lactones.24Ramón Martínez-Mármol, Hericerin derivatives from Hericium erinaceus exert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memorybiorxiv. 2020
Lion’s mane is known to boost memory, increase brain energy, lower brain fog, and help with overall learning.
Alpha GPC
Like the maritime pine bark extract, alpha gpc is used for Alzheimer’s, stroke, and dementia is reduced caused by reduced blood flow to the brain.25Song Hee Lee et al, Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairmentBrain Res. 2017
It also enhances memory and thinking skills.26Song Hee Lee et al, Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairmentBrain Res. 2017
Best Nootropic Stack For A Calm Mood
The best stack for a calming mood includes the following ingredients:
Magnesium
Magnesium is among the most abundant minerals in the body.
It controls the activity of neuronal ion channels in the brain.
Magnesium, through its effect on neuron plasticity, boost cognitive function, recall, and memory.27Inna Slutsky et al, Enhancement of learning and memory by elevating brain magnesiumNeuron. 2010
Magnesium threonate is typically the best form for mental performance due to its ability to cross the blood brain barrier.
Bacopa monnieri
Among the best nootropics accessible, Bacopa monnieri has been used as an Ayurvedic for several years. Researchers have shown that Bacopa is as effective for anxiety as Lorazepam.
The compound is resistant to memory loss and has been shown to enhance brain health and cognitive functions.28ChuenjidKongkeaw et al, Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extractJournal of Ethnopharmacology. 2014
Reishi
Reishi mushroom is a powerful immune system supplement when combined with adaptogenic mushrooms like shiitake mushrooms.
It has potential nootropic effects and provides mood support and enhanced brain focus and energy.29Oleg B Shevelev et al, Hypotensive and neurometabolic effects of intragastric Reishi (Ganoderma lucidum) administration in hypertensive ISIAH rat strainPhytomedicine. 2018
Best Nootropic Stack For Neuroprotection
If neuroprotection is the main aim behind your nootropic stack, then it should contain the following ingredients:
Alpha GPC (or CDP Choline)
Alpha gpc is used for Alzheimer’s and stroke. It also cures dementia caused by reduced blood flow to the brain.30Song Hee Lee et al, Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairmentBrain Res. 2017
It also benefits cognition in individuals with mild cognitive impairment.
It also enhances memory and thinking skills.31Song Hee Lee et al, Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairmentBrain Res. 2017
Improving blood circulation helps in neuroprotection.32Song Hee Lee et al, Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairmentBrain Res. 2017
Methylene Blue
Methylene blue is a potent synthetic nootropic that increases mood memory and longevity.
It’s a mitochondrial booster with many cognitive and physical benefits.
Although not typically known as a brain supplement, methylene blue has been touted for improving cognitive performance.
It also eliminates social anxiety and makes you feel younger.
Sulbutiamine
Sulbutiamine is a more robust version of thiamine suitable to improve cognitive function.
It is one of the best standalone nootropic supplements.33Bernardo Starling-Soares et al, Role of the Synthetic B1 Vitamin Sulbutiamine on HealthJ Nutr Metab. 2020
It has been linked to memory improvement and improving a wide array of cognitive skills. 34Bernardo Starling-Soares et al, Role of the Synthetic B1 Vitamin Sulbutiamine on HealthJ Nutr Metab. 2020
Best Nootropic Stack For Cognitive Energy
Cognitive energy can be enhanced using the following ingredients in a nootropic stack.
Sulbutiamine
Sulbutiamine is stronger in effect than thiamine.
Sulbutiamine is essential for improving concentration and vigor and reducing memory loss.35J Micheau et al, Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediationPharmacol Biochem Behav. 1985
It is able to prevent inflammation helping the brain make wise decisions by keeping the brain functioning.
Sulbutiamine is required for the production of the neurotransmitter acetylcholine (ACh).36J Micheau et al, Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediationPharmacol Biochem Behav. 1985
In your brain, ACh is used to transmit messages between neurons.
It is also essential for memory, learning, and cognition.37J Micheau et al, Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediationPharmacol Biochem Behav. 1985
Sulbutiamine makes your body more resilient to stress.
Insufficient energy might affect one’s motivation and mood.
Thiamine can improve your mood and protect you from anxiety and despair.38J Micheau et al, Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediationPharmacol Biochem Behav. 1985
Alpha GPC (or CDP Choline)
Alpha GPC improves cognitive function and mental performance. It can be considered both a medication and a supplement.39Song Hee Lee , Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairmentBrain Res. 2017
Adrafinil
Adrafinil is a stimulant that fights against fatigue, increases the processing performance of the brain, boosts energy, and increases wellbeing.40Ana Sousa et al, Pharmacokinetic and pharmacodynamic of the cognitive enhancer modafinil: Relevant clinical and forensic aspectsSubstance Abuse. 2020
FDA’s Warning On Mixing Supplements and Nootropics
The FDA warns producers and consumers about mixing supplements and nootropics for fear of adverse reactions.
Combining prescription drugs and nutritional supplements may have adverse and fatal effects.
Some consumers might think that a supposedly “natural” product, such as fish oil or herbal supplement, can do them no harm.
Safe does not always equate to natural, therefore very natural nootropic stack may not be safe.
Bring a list of all the prescription drugs and dietary supplements you take whenever you visit a doctor’s office.
Include the dosages and the number of times you take them each day.
Some people find it most convenient to pack up all of their prescription drugs and dietary supplements in one suitcase before going to the doctor.
Call your doctor before adding a dietary supplement to your daily regimen and inform them of all the supplements and prescriptions you are currently taking.
Additionally, let your doctor know if anything about your health has changed, especially if you are pregnant, nursing, or have recently undergone surgery or an illness.41FDA 2022, Mixing Medications and Dietary Supplements Can Endanger Your HealthFDA 2022
This is also one big reason why I tout the preformulated nootropic stacks over making your own nootropic stack.
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- 2Noor Azuin Suliman et al, Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural NootropicEvid Based Complement Alternat Med. 2016
- 3Amy L. Roe et al, The Safety and Efficacy of Botanicals with Nootropic EffectsCurr Neuropharmacol. 2021
- 4Ruchi Malik et al Towards better brain management: nootropicsCurr Med Chem. 2007
- 5Noor Azuin Suliman et al, Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural NootropicEvid Based Complement Alternat Med. 2016
- 6Philippe Taupin, Nootropic agents stimulate neurogenesis. Brain Cells, Inc.: WO2007104035Expert Opin Ther Pat. 2009
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- 9Noor Azuin Suliman et al, Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural NootropicEvid Based Complement Alternat Med. 2016
- 10Noor Azuin Suliman et al, Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural NootropicEvid Based Complement Alternat Med. 2016
- 11Bryant J.Jongkees et al, Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands—A reviewJournal of Psychiatric Research. 2015
- 12Bryant J.Jongkees et al, Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands—A reviewJournal of Psychiatric Research. 2015
- 13Jorge Gutiérrez-Hellín and David Varillas-Delgado, Energy Drinks and Sports Performance, Cardiovascular Risk, and Genetic Associations; Future ProspectsNutrients 2021
- 14Kyle R. Roell, An Introduction to Terminology and Methodology of Chemical Synergy—Perspectives from Across DisciplinesFront. Pharmacol., 2017
- 15Kyle R. Roell, An Introduction to Terminology and Methodology of Chemical Synergy—Perspectives from Across DisciplinesFront. Pharmacol., 2017
- 16Kyle R. Roell, An Introduction to Terminology and Methodology of Chemical Synergy—Perspectives from Across DisciplinesFront. Pharmacol., 2017
- 17Kyle R. Roell, An Introduction to Terminology and Methodology of Chemical Synergy—Perspectives from Across DisciplinesFront. Pharmacol., 2017
- 18Kyle R. Roell, An Introduction to Terminology and Methodology of Chemical Synergy—Perspectives from Across DisciplinesFront. Pharmacol., 2017
- 19Kyle R. Roell, An Introduction to Terminology and Methodology of Chemical Synergy—Perspectives from Across DisciplinesFront. Pharmacol., 2017
- 20Noor Azuin Suliman et al, Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural NootropicEvid Based Complement Alternat Med. 2016
- 21Noor Azuin Suliman et al, Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural NootropicEvid Based Complement Alternat Med. 2016
- 22Noor Azuin Suliman et al, Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural NootropicEvid Based Complement Alternat Med. 2016
- 23Zizhen Xie et al, A review of sleep disorders and melatoninNeurol Res. 2017
- 24Ramón Martínez-Mármol, Hericerin derivatives from Hericium erinaceus exert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memorybiorxiv. 2020
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- 27Inna Slutsky et al, Enhancement of learning and memory by elevating brain magnesiumNeuron. 2010
- 28ChuenjidKongkeaw et al, Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extractJournal of Ethnopharmacology. 2014
- 29Oleg B Shevelev et al, Hypotensive and neurometabolic effects of intragastric Reishi (Ganoderma lucidum) administration in hypertensive ISIAH rat strainPhytomedicine. 2018
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- 33Bernardo Starling-Soares et al, Role of the Synthetic B1 Vitamin Sulbutiamine on HealthJ Nutr Metab. 2020
- 34Bernardo Starling-Soares et al, Role of the Synthetic B1 Vitamin Sulbutiamine on HealthJ Nutr Metab. 2020
- 35J Micheau et al, Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediationPharmacol Biochem Behav. 1985
- 36J Micheau et al, Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediationPharmacol Biochem Behav. 1985
- 37J Micheau et al, Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediationPharmacol Biochem Behav. 1985
- 38J Micheau et al, Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediationPharmacol Biochem Behav. 1985
- 39
- 40Ana Sousa et al, Pharmacokinetic and pharmacodynamic of the cognitive enhancer modafinil: Relevant clinical and forensic aspectsSubstance Abuse. 2020
- 41FDA 2022, Mixing Medications and Dietary Supplements Can Endanger Your HealthFDA 2022
