11 Best Supplements For Neuroplasticity

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Key Takeaways:

Neuroplasticity is the brain’s ability to learn new things


BDNF is the main currency of neuroplasticity


Specific supplements like choline, b-vitamins, DHA, and nootropics can help boost brain neuroplasticity

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Hey there! Welcome to my review of the best supplements for neuroplasticity.

As you probably know, some specific nootropics and supplements can help boost your brain’s neuroplasticity.

As a medical school student in my 40s, discovering new molecules to help my brain adapt to the rigors of learning complex medical information is paramount to my success.

This is why I’ve spent countless hours researching and testing different supplements that boost neuroplasticity.

Although neuroplasticity is a complex process that is not fully understood, we do know many factors that enhance its capabilities. 

We also know that a handful of supplements on the market today can help enhance neuroplasticity.  

If you’re looking to boost your brain’s ability to retain data, improve focus and adapt to new things, the following recommended supplements will help you in your journey.

The following article is a deep dive into the science of neuroplasticity and supplements that support it.

If you’re ready to discover the best supplements for neuroplasticity, let’s jump into it! 

Best Supplements For Neuroplasticity -Quick Guide-



#1 For Neuroplasticity
Learn MoreBuy 3 and get 2 Free + 🏷️ 20% off Everything
Mind Lab Pro

Mind Lab Pro

Supercharged Neuroplasticity
Learn MoreBuy 3 bottles, get 1 free with our links
Nootropics Depot Alpha-GPC

Nootropics Depot Alpha-GPC

Choline on demand
CZTL Methylene Blue

CZTL Methylene Blue

High-Quality, Low-Cost
Piracetam - Cosmic Nootropics

Piracetam – Cosmic Nootropics

The OG nootropic
Learn MoreUse code: HOLISTIC5 To Save 5%
Lion's Mane - Real Mushroom

Lion’s Mane – Real Mushroom

#1 Mushroom For Neuroplasticity
Learn MoreBest Value, Highest Quality Mushroom
Omega 3 DHA - Nootropics Depot

Omega 3 DHA – Nootropics Depot

High Potency Omega 3-Rich DHA
Melatonin- Nootropics Depot

Melatonin- Nootropics Depot

#1 Deep Sleep PromoteMelatonin is a hormone produced by the br


The miracle ingredient in energy drinks
Acetyl L-Carnitine (ALCAR)

Acetyl L-Carnitine (ALCAR)

Boost energy levels and athletic performance
Magnesium Breakthrough

Magnesium Breakthrough

#1 Magnesium Product
Learn MoreUse code: HOLISTICNOOTROPICS to save 10%

Neuroplasticity Supplements FAQ

Best Supplements For Neuroplasticity

Science-backed nutrition for your brain

Mind Lab Pro

Mind Lab Pro
Shop NowBuy 3 bottles, get 1 free with our links
Shop NowBuy 3 bottles, get 1 free with our links
  • Designed to optimize cognitive functions through 11 natural ingredients that work in 6 bio-pathways

  • Boosts serotonin levels which can help improve your mood, sleep quality, appetite control, stress management,

  • Mind Lab Pro helps improve focus, memory, clarity, energy levels without relying on stimulants or artificial additives

  • Contains premium forms of each ingredient for enhanced potency and activity, while avoiding potential side effects associated with lower quality ingredients

Mind Lab Pro aims to provide an all-in-one solution for improving mental health & performance without any harsh side effects like those associated with prescription medications or other supplements on the market today.

It contains 11 clinically studied ingredients that work synergistically to improve focus, memory, clarity, and energy levels. For example, Rhodiola Rosea helps reduce fatigue, while Citicoline increases alertness and concentration. Phosphatidylserine helps protect neurons from damage, while L-Theanine helps reduce stress and anxiety.

In addition to these ingredients, Mind Lab Pro also contains Lion’s Mane Mushroom, which has been shown to stimulate Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). These proteins are important for developing new neurons in the brain and releasing neurotransmitters such as dopamine, which can help improve mood and focus.

Mind Lab Pro has been developed to affect the following six key bio-pathways:

  • Neuro-Energy Metabolism
  • Antioxidant Enhancements
  • Neurotransmitter Support
  • Neural Structures Protection
  • Stress/Anxiety Resistance
  • Brain Circulation/Oxygenation

The recommended dosage is two capsules daily in the morning or early afternoon. You can safely increase your dose to four capsules daily during increased cognitive demand. Taking Mind Lab Pro with water, juice, or coffee is best.

I’ve been using Mind Lab Pro for several extended periods of high-demand brain activity, and I can confidently say that it lives up to its claims.

If you are looking for a natural supplement to help boost your cognitive performance, then Mind Lab Pro is an excellent choice to get the most out of your day and start building toward long-term cognitive performance.

Maximize your mental performance for peak productivity


Shop NowGet 20% off three bottles
Shop NowGet 20% off three bottles
  • Improves oxygenation, nutrient absorption and stimulate neurotransmitter production for better cognitive function

  • Stimulates the production of neurotransmitters

  • Supports increases in concentration, learning, short-term memory, and problem-solving

  • Reduce age-related cognitive decline while improving overall mental performance

NooCube is a revolutionary dietary supplement that provides cognitive benefits to help people with their everyday tasks.

It contains a unique blend of natural ingredients such as Lutemax, Bacopa monnieri, Huperzia Serrata, Pterostilbene, Resveratrol, L-theanine, L-tyrosine, Alpha GPC, Oat straw extract, Cat’s claw, Vitamin B1, Vitamin B7, and Vitamin B12.

Lutemax is derived from lutein and zeaxanthin and helps support optimal health by helping the body absorb light better. Bacopa monnieri helps boost memory and concentration by supporting neurotransmitters in the brain.

Huperzia Serrata boosts mental clarity by making it easier for your brain to process information quickly and accurately. Pterostilbene helps preserve healthy brain cells, while Resveratrol promotes overall brain health.

L-theanine works in combination with caffeine to provide more focused alertness without the jittery side effects generally associated with the caffeine alone.

L-Tyrosine aids in reducing mental fatigue, while alpha GPC helps improve memory formation after exercise or physical stress. Oat straw extract helps increase mental energy levels while cat’s claw supports cognitive function through its anti-inflammatory properties. Vitamins B1 (thiamin), B7 (biotin), and B12 (cobalamin) support healthy nervous system functioning crucial for all aspects of neural communication within the brain.

NooCube combines this unique blend of natural ingredients to create an effective solution for people looking to boost their focus and concentration when performing daily tasks or studying for exams or projects.

By providing improved cognitive abilities without the dangerous side effects of other prescription drugs, NooCube is an easy alternative for anyone looking to get ahead in life without risking their long-term health or productivity levels.

As someone who has used NooCube regularly, I can confidently say that it has made an incredible difference in my day-to-day life since taking it regularly over the past few months.

The combination of natural ingredients has allowed me to focus on my tasks throughout the day while providing increased energy levels so I can stay productive longer into the night if needed.

Overall I think NooCube is one of the best supplements out there right now – allowing people to boost their cognitive abilities safely and naturally – which is why I highly recommend it.

Choline on demand

Nootropics Depot Alpha-GPC

  • Powder and Capsule Formulations

  • USA Made

  • Dairy, Gluten, Yeast, and Artificial Additive Free

  • Backed by Research as a Nootropic Supplement

  • Derived from GMO-Free Soy Lecithin

  • Lab Tested and Verified for Product Purity, Potency, and Identity

Nootropics Depot offers a high-quality alpha-GPC product available in both capsule and powder formulations. It is manufactured in the USA and does not contain dairy, gluten, yeast, or artificial additives.

This product is backed by ample research to support its use as a nootropic and effective daily supplement for improving memory, enhancing learning speed, and improving mental clarity.

The alpha-GPC found in this supplement is derived from soy lecithin, and it does not contain GMOs. It is also lab-tested and verified for product purity, potency and identity so that you don’t have to worry about inaccurate labeling, presence of contaminants, or use of any unapproved drugs.

The powder formulation can easily be dissolved with water or any other beverage. The capsule formulation contains 150mg of α-GPC in each capsule which can be taken once or twice a day after meals as advised by your health care professional.

As of May 2022, a pack of 60 capsules will cost you somewhere between $16 USD to $35 USD.

High-Quality, Low-Cost

CZTL Methylene Blue

  • Pure Methylene Blue

  • No fillers, preservatives, or sweeteners

  • CZTL is the most cost-effective methylene blue option. Bulk orders are available

  • Fast delivery, with good customer support on all orders

  • Every order comes with a certificate of analysis of lab testing for purity

  • Each order includes instructions on how to prepare and dose

CZTL is high-quality, USP-grade methylene blue.

Every batch is purity tested for heavy metals, and each order includes a certificate of analysis confirming its purity.

What I love most about CZTL is that it is the most cost-effective methylene blue on the market.

You can buy a bulk load of pure methylene blue and be set for a long time.

They also ship internationally to over 75 countries.

The OG nootropic

Piracetam – Cosmic Nootropics

Piracetam - Cosmic Nootropics
Shop NowUse code: HOLISTIC5 To Save 5%
Shop NowUse code: HOLISTIC5 To Save 5%
  • Has the ability to increase blood flow to the brain, which enhances cognitive function

  • Work by modulating neurotransmitter levels in the brain

  • Helps protect against age-related memory decline.

  • Increases acetylcholine in the brain to boost learning and memory formation.

Piracetam is a popular nootropic supplement that is claimed to offer a range of cognitive benefits. These benefits include improved memory, concentration and focus. Piracetam is also said to help protect the brain from age-related damage.

Piracetam supplements are generally well-tolerated, but some people may experience side effects such as headache, nausea or nervousness.

If you’re considering taking Piracetam supplements, it’s important to talk to your doctor first to discuss whether they are right for you.

#1 Magnesium Product

Magnesium Breakthrough

Magnesium Breakthrough
Shop NowUse code: HOLISTICNOOTROPICS to save 10%
Shop NowUse code: HOLISTICNOOTROPICS to save 10%
  • Magnesium restores balance to the mind and body

  • Improves symptoms of ADHD in some people

  • Triggers relaxation response

  • Steadies the mind for restful sleep

Magnesium is an essential mineral that is involved in over 300 metabolic processes in both the mind and body.

These metabolic processes include neurotransmitter synthesis including dopamine.

In today’s hectic society filled with nutrient-depleted food, magnesium deficiency is on the rise.

Subsequently most people with ADHD exhibit low levels of magnesium.1T Kozielec, et al. Assessment of magnesium levels in children with attention deficit hyperactivity disorder (ADHD), Magnes Res. 2006

Recent research into magnesium’s influence on ADHD points to a statistically significant relationship between magnesium deficiency and ADHD.2Mohammad Effatpanah, et al. Magnesium status and attention deficit hyperactivity disorder (ADHD): A meta-analysisPsychiatry Res. 2019

In clinical studies, supplementation with Magnesium has shown effective in improving ADHD symptoms. 3M Mousain-Bosc, et al. Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. I. Attention deficit hyperactivity disorders, Magnes Res. 2006

Ultimately, magnesium is highly effective at calming the body’s stress response, inducing relaxation, and steadying the mind.

Learn more about how Magnesium works in treating ADHD and other symptoms.

Lion’s Mane – Real Mushrooms

Lion’s Mane – Real Mushroom

Lion's Mane - Real Mushroom
Shop NowBest Value, Highest Quality Mushroom
Shop NowBest Value, Highest Quality Mushroom
  • Clinically proven to boost neurogenesis

  • Contains Anti-Inflammatory Compounds

  • Shown to help improve memory, focus, concentration and overall cognitive performance.

  • Can boost immunity in the body

Lion’s Mane mushroom is a potent nootropic that stands out because of its unique ability to improve focus, concentration, and memory.

This potent mushroom has been used in traditional Chinese medicine for centuries, but recent research has uncovered even more benefits. Studies have shown that Lion’s Mane contains compounds called hericenones and erinacines, which can help stimulate the growth of nerve cells in the brain. This means that this nootropic not only helps improve mental performance and focus but it also helps to protect against age-related memory decline.

On top of this, Lion’s Mane also has amazing anti-inflammatory properties that can help reduce inflammation in the body, helping with conditions like arthritis and digestive issues like constipation. It has even been found to boost the immune system by increasing white blood cells and antibodies.

Finally, some heart health benefits are associated with Lion’s Mane mushrooms as well – studies have shown that these mushrooms may help reduce cholesterol levels and lower blood pressure. For those looking for a natural way to boost their mental performance or protect against age-related memory decline, look no further than Lion’s Mane mushroom!

#1 Deep Sleep PromoteMelatonin is a hormone produced by the br

Melatonin- Nootropics Depot

  • Melatonin is the #1 supplement for promoting deep sleep and regulating sleep/wake cycles

  • Beneficial for mental disorders, insomnia, neurodegenerative disorders, GI conditions

  • Low toxicity and side effects

  • May contribute to daytime drowsiness

  • Affordable pricing and fast shipping from Nootropics Depot

Melatonin is a hormone produced by the brain in response to darkness.  It helps to regulate our circadian rhythms or internal body clock and plays a vital role in regulating our sleep-wake cycle.

Melatonin is produced by the pineal gland located in the brain, and its production is influenced by light exposure. When it gets dark, melatonin production increases, helping us to feel sleepy. During daylight hours, melatonin levels are low and we feel more alert and awake.

Research has shown that it interacts with various brain parts involved in regulating sleep-wake cycles, such as the hypothalamus and suprachiasmatic nucleus (SCN). Melatonin also binds to receptors on cells throughout the body, influencing physiological processes such as blood pressure and temperature regulation.

In addition to its role in regulating sleep-wake cycles, melatonin has been studied for its potential antioxidant properties. It has been found to be an effective scavenger of highly toxic hydroxyl radicals, which can cause oxidative damage to cells. This suggests that melatonin may have beneficial effects on health beyond just improving sleep quality.

Supplemental melatonin is considered the first-line pharmacologic therapy for the treatment of insomnia by the American Academy of Family Physicians (AAFP) and is considered generally safe with few potential side effects.

Nootropics Depot melatonin is lower dosed at 300mcg than most other melatonin supplements, yet delivers powerful results for most users.

Nootropics Depot Melatonin Customer Reviews

“Well I have to say that I was sceptical about the tiny dose of Melatonin, after always taking at least 3 mg per night. But the tiny dose seems to work just fine, I take it with Magnesium at night and have been having lovely sleeps :)” – Tania Fernyhough (June ’22)

“Favorite dosage of melatonin here. Most others are 5mg and above which leave me groggy in the morning. This pill gives my body a hint that it’s time for bed. They don’t keep me asleep through the night but act as a solid start” – Adam (May ’20)

The miracle ingredient in energy drinks


  • Commonly found in many energy drinks and supplements

  • Can improve mental focus and physical performance

  • Helps to protect the brain from age-related damage and oxidative stress

Taurine is an amino sulfonic acid, but it is often called an organic acid. It is found in large quantities in the brain and eyes. Taurine has several nootropic effects. It can help improve memory and learning, and it also has neuroprotective effects. Taurine supplements can also help reduce anxiety and depression.

The exact mechanism of action is not fully understood, but it is thought that taurine works by modulating neurotransmitters in the brain. Taurine is also known to have anti-inflammatory and antioxidant effects. These properties make taurine a potentially powerful nootropic supplement. Taurine is generally well-tolerated, but it can cause some side effects, such as headaches, insomnia, and anxiety.

Overall, taurine is a safe and effective nootropic supplement with many potential benefits.

Boost energy levels and athletic performance

Acetyl L-Carnitine (ALCAR)

  • Improve cognitive function

  • Protect the brain from damage

  • Boost energy levels

  • Enhance athletic performance

Acetyl L-Carnitine (ALCAR) is a supplement that has many potential benefits. It is most commonly known for its nootropic effects, which means that it can help to improve cognitive function.

ALCAR is thought to work by increasing levels of acetylcholine, a neurotransmitter that is essential for memory and learning.

ALCAR has been shown to protect the brain from damage caused by free radicals, and it may even help to reverse some of the cognitive declines that occurs with age.

In addition to its nootropic effects, ALCAR has also been shown to boost energy levels and athletic performance. This is thought to be due to its ability to increase levels of carnitine, an amino acid that helps the body to burn fat for fuel.

Additionally, ALCAR has been shown to improve heart health by reducing oxidative stress and improving blood flow.

Overall, ALCAR is a safe and effective supplement that offers many potential benefits.

High Potency Omega 3-Rich DHA

Omega 3 DHA – Nootropics Depot

  • DHA plays a critical role in the development and functioning of the brain

  • Improved Cognitive Performance: The omega-3 fatty acid DHA found in fish oil has been shown to boost cognitive performance, memory recall and concentration, making it a great nootropic.

  • Neuroprotection: DHA can help protect the brain from age-related diseases like Alzheimer’s and dementia

  • Anti-inflammatory properties of DHA help boost your overall memory by improving formation of new memories

  • Optimized Learning & Attention Span: Supplementing with DHA may also help optimize learning abilities by improving attention span and focus, allowing you to get more done in less time.

  • Reduced Stress and Anxiety: Omega-3 fatty acids have been linked to lower levels of stress hormones such as adrenaline and cortisol, helping reduce feelings of anxiety and improving your mood.

DHA is an essential omega-3 fatty acid that plays a critical role in the development and functioning of the brain.

Studies have found that supplementing with DHA can improve cognitive performance, memory recall, focus and concentration.

Not only can it help protect against age-related diseases like Alzheimer’s and dementia, but it also helps reduce stress hormones such as adrenaline and cortisol – giving you a mood boost while improving your overall mental health.

DHA has also been found to have anti-inflammatory properties, which means it can help improve the formation of new memories in the brain, helping to boost your overall memory power.

One of the most significant benefits I’ve seen from DHA supplementation is its ability to optimize learning abilities by improving your attention span and focus – allowing you to get more done in less time!

In short, DHA is an excellent option for getting those extra brain-loving benefits.

What Is Neuroplasticity

Neuroplasticity is the ability of the brain to change and adapt in response to new experiences or stimuli. 1Patrice Voss, Maryse E. Thomas, J. Miguel Cisneros-Franco, and Étienne de Villers-Sidani, Name of studyFront Psychol. 2017

It is sometimes called “brain plasticity” or “neuroplasticity.” 

Through neuroplasticity, our brains can create new neural pathways, strengthen existing connections, and even rewire brain areas to help us develop new skills or recover from neurological disorders.2Ariel Rokem , Michael A SilverCholinergic enhancement augments magnitude and specificity of visual perceptual learning in healthy humansCurr Biol. 2010

Neuroplasticity is a critical factor in learning new things. It has been increasingly studied in recent years, with fascinating results showing its potential to improve mental health, enhance cognitive function, and more.3Joyce Shaffer, Neuroplasticity and Clinical Practice: Building Brain Power for HealthFront Psychol. 2016

Can You Enhance Neuroplasticity?

Yes, it is possible to enhance neuroplasticity. Various methods, such as physical activity, cognitive training, and meditation, have a positive effect on neuroplasticity.4Cristy Phillips, Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during AgingNeural Plast. 2017

Additionally, certain supplements and nootropics, both natural and synthetic, have been found to offer enhanced benefits when taken regularly.  

By using these different methods in combination with one another, it is possible to enhance the effects of neuroplasticity greatly.

Foods and Lifestyle Factors That Reduce Neuroplasticity

Diet and lifestyle can have a significant impact on neuroplasticity.  

Eating processed food, drinking alcohol, smoking, and leading an inactive lifestyle can reduce the brain’s ability to form new neural pathways.5Cristy Phillips, Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar DisorderNeural Plast. 2017

Furthermore, chronic stress can interfere with the body’s ability to adapt to changes in environment or stimuli, which is one of the key functions of neuroplasticity. 6Simon Rosenbaum et al, Physical activity in the treatment of Post-traumatic stress disorder: A systematic review and meta-analysisPsychiatry Res. 2015

To maintain or even improve cognitive abilities and mental well-being, it is vital to have a healthy balanced diet full of fresh fruits and vegetables, healthy proteins and fats, as well as adequate amounts of exercise each day.  

Additionally, reducing stress levels through relaxation techniques such as meditation or yoga can help promote mental health and enhance neuroplasticity.

Neuroplasticity and Learning

Neuroplasticity has a profound effect on your ability to learn.  

It allows your brain to form new neural pathways, making it easier to acquire new information and retain memories.7B Jacobs , A B Scheibel, A quantitative dendritic analysis of Wernicke’s area in humans. I. Lifespan changesJ Comp Neurol. 1993

Neuroplasticity also creates connections between different parts of your brain, allowing you to solve problems creatively and develop innovative ideas.8Bryan Kolb , Robbin Gibb, Grazyna Gorny, Experience-dependent changes in dendritic arbor and spine density in neocortex vary qualitatively with age and sexNeurobiol Learn Mem. 2003

Finally, neuroplasticity helps you adjust to new circumstances and challenges you may face daily.  

All these traits are essential for mastering any skill or knowledge, making neuroplasticity an integral part of my learning process.

Neuroplasticity and Memory

Neuroplasticity also plays an essential role in memory formation and recall.  

The brain can quickly store and access information by forming new neural pathways.  

Neuroplasticity can also help strengthen existing memories, making remembering past experiences and information more accessible.9Warren H Meck , Christina L Williams, Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespanNeurosci Biobehav Rev. 2003

In addition, neuroplasticity has been linked to an increased ability to form associations between different concepts, allowing the brain to categorize information more efficiently for quicker recall. 10Denise C. Park, PhD et al, The aging mind: neuroplasticity in response to cognitive trainingDialogues Clin Neurosci. 2013

These factors create a solid foundation for long-term memory formation, making neuroplasticity a key factor for memory capabilities.

Neuroplasticity and Mood Disorders

Neuroplasticity has also been linked to depression, but in a more complex manner than one might expect.  

Research suggests that neuroplasticity can be beneficial and detrimental to people with depression. 11Zhen Wang et al, Antidepressant-like activity of resveratrol treatment in the forced swim test and tail suspension test in mice: the HPA axis, BDNF expression and phosphorylation of ERKPharmacol Biochem Behav. 2013

On the positive side, neuroplasticity can help people with depression create new neural pathways for emotional regulation, allowing them to understand better and manage their feelings of distress.12Ioana Rădulescu, et al Neuroplasticity and depression: Rewiring the brain’s networks through pharmacological therapyExp Ther Med. 2021

Conversely, some studies suggest that changes induced by neuroplasticity may contribute to the development of negative thought patterns, further exacerbating the symptoms of depression.13Wei Liu et al, The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal CortexNeural Plasticity in Mood Disorders. 2017

Ultimately, it appears that while neuroplasticity can help individuals learn to cope with depression over time, seeking professional help is crucial if symptoms persist or worsen.


Neuroplasticity is a phenomenon that can boost cognition in many profound ways and can be enhanced with proper lifestyle and diet habits.

The right supplements and nootropics, such as those mentioned above, can significantly enhance your mind’s neuroplasticity, boosting many aspects of your cognition.  

Remember to consult your physician to see if these changes suit you. 

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Erik Abramowitz is a certified Nutritional Therapy Practitioner (NTP), Naturopathic Doctoral student, health coach, and father. He is the primary content creator for HolisticNootropics.com and the host of the Holistic Nootropics Podcast.

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