11 Best Nootropics For Hangovers

Key Takeaways:

Hangovers are caused primarily by the buildup of acetaldehyde in the body

Nootropics can’t cure a hangover, but may ease some of the symptoms

Some nootropics, such as NAC, can be taken before a night out as a preventative measure to minimize the damage

Other nootropics, such as noopept, can provide some relief the morning after

11 Best Nootropics For Hangovers

So, you drank too much last night and want it all to stop hurting? We’re all adults, and we know occasional overindulgence is just a part of life.

No judgments here, we’ve been there too. Fortunately, there are a few nootropics that can at least ease the pain a bit.

Related: Mind Lab Pro vs Qualia Mind Head To Head Review

What Are The Best Nootropics For Hangovers – Quick Answers

Mind Lab Pro #1

Mind Lab Pro

Science-backed nutrition for your brain
Learn MoreBuy 3 bottles, get 1 free with our links
Chaga #2


Improve digestion & detoxify your body
Chaga #3


Improve digestion & detoxify your body
Magnesium Breakthrough #4

Magnesium Breakthrough

#1 Magnesium Product
Lion's Mane Mushrooms #5

Lion’s Mane Mushrooms

Superfood for tackling ADHD
Cordyceps Mushroom #6

Cordyceps Mushroom

The Mushroom for Energy
Qualia Mind #7

Qualia Mind

Most Nootropics Per Serving
Oxiracetam #8


Popular synthetic learning and memory aid
Noopept #9


World's #1 Selling Nootropic
Citicoline #10


Get more done in your day
NAC #11


Powerful mood stabilizer
L-Theanine #12


The all-natural "chill pill"
best nootropics for hangovers, best supplement for a hangover, hangover cure
Some supplements may take the edge off the hurt.

Can You Cure A Hangover With Nootropics?

First, let’s talk about why you feel so bad in the first place. An alcohol hangover happens physiologically when enough ethanol (the active ingredient in all alcoholic drinks) gets converted to toxic acetaldehyde. If acetaldehyde builds up faster than your liver can clear it out, you wind up permanently poisoned.

  • 11 All-Natural Nootropics 
  • Boost Mental Energy, Lower Fatigue
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  • Stress Reduction

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Acetaldehyde is the primary source of the dehydration, nausea, headaches, and general ill-being of hangovers. First, the bad news: there’s no magic bullet that will get you back to 100% instantly. The only things that can do that are abstinence (which is probably already not an option for you if you’re reading this article) and time.

Plenty of water, sleep, and nutritious food will also get you back on your feet quicker. But, you probably knew all that already, so let’s get to the nootropics. We can’t promise that all these will work for you, but you may find something that makes Sunday morning a bit less miserable.

Read More: Why You Should Never Buy Nootropics From Amazon

Best Nootropic Hangover “Cures”

Science-backed nutrition for your brain

Mind Lab Pro

Mind Lab Pro
Check PriceBuy 3 bottles, get 1 free with our links
Check PriceBuy 3 bottles, get 1 free with our links
  • Overcome a hangover with efficiency

  • Reduce fatigue and improve mental clarity

  • Easy to take-on the go, no more struggling through mornings after partying all night

  • Increase attention span, memory recall, motivation and cognitive performance

Mind Lab Pro is a preformulated Nootropic “stack” that includes 11 cognitive-enhancing ingredients that help you recover from a nasty hangover.

It includes the perfect mix of nootropics, amino acids, and adaptogens to optimize your mind after a rough night.

Starting your morning (or afternoon) with Mind Lab Pro delivers the nutrition your brain desperately needs.

This stack replenishes neurotransmitters, stabilizes the glutamate-GABA balance, and lowers inflammation, all of which are necessary components of overcoming a nasty hangover. 

The supplements themselves are 3rd party tested and free of excess fillers and toxic ingredients. 

I love this stack for nootropic newbies and experienced nootropic users alike.


  • Proven to boost overall cognitive performance including memory, focus, mood, creativity, motivation, and overall well-being.
  • Potent blend of all-natural nootropics, herbs, amino acids, vitamins, and minerals.
  • Good for Experienced Biohackers and those new to nootropics.
  • Caffeine Free
  • No artificial fillers or toxic preservatives
  • Affordable Price


  • Ingredients are lower dosed.
  • Fewer ingredients than other leading nootropic stacks

Improve digestion & detoxify your body
  • Supercharge your liver with the most potent of antioxidants

  • Provide all-natural relief for alcoholic hangovers

  • Increase levels of good cholesterol (LDL) and lower levels of bad cholesterol (HDL)

  • Decreases oxidative stress at the tissue level after excessive drinking

Chaga is a must-have in anyone’s organic hangover protocol.

Chaga mushroom is a great source of antioxidants making it an excellent anti-inflammatory organic ingredient.1Yang Hee Hong, Effects of the herb mixture, DTS20, on oxidative stress and plasma alcoholic metabolites after alcohol consumption in healthy young men, Integr Med Res. 2016

 This dusky textured mushroom has been found to combat oxidative stress, and decrease low-density lipoprotein (LDL), aka the bad cholesterol.2Weifa Zheng , Meimei Zhang, Yanxia Zhao, Kangjie Miao, Shenyuan Pan, Feng Cao, Yucheng Dai, Analysis of antioxidant metabolites by solvent extraction from sclerotia of Inonotus obliquus (Chaga), Phytochem Anal. 2011

This medicinal mushroom also relieves oxidative stress at the tissue level after excessive drinking.

Freshcap Mushrooms provide the highest percentage of beta glucans and fruiting body nutrients, making this mushroom product my preferred choice for Chaga.

#1 Magnesium Product

Magnesium Breakthrough

  • Alcohol depletes magnesium and takes a toll on your body when it’s consumed

  • Magnesium can help with alcohol dehydrogenase production in the liver

  • With regular use, you will reduce the negative side effects associated with heavy drinking such as pain or nausea

Like B vitamins, magnesium is an important micronutrient that your body needs for a variety of processes. Alcohol depletes magnesium through the urine, which can cause many negative side-effects.3Altura BM, Altura BT, Gupta RK. Alcohol intoxication results in rapid loss in free magnesium in brain and disturbances in brain bioenergetics: relation to cerebrovasospasm, alcohol-induced strokes, and barbiturate anesthesia-induced deaths, Magnes Trace Elem. 1991-1992

Luckily, taking magnesium supplements before and after you drink can ease the pain. Magnesium supports alcohol dehydrogenase production in the liver.

Alcohol dehydrogenase is the enzyme that breaks down alcohol so that your body can eliminate it. Magnesium can help metabolize and get rid of dangerous toxins faster.4HenryWeiner, KojiroTakahashi. Effects of magnesium and calcium on mitochondrial and cytosolic liver aldehyde dehydrogenases, Pharmacology Biochemistry, and Behavior. 1983

Superfood for tackling ADHD

Lion’s Mane Mushrooms

  • Promote liver function and blood circulation

  • Reduce stress levels and anxiety

  • Improve general mood by increasing serotonin levels in the brain

  • Enhance cognitive ability

Lion’s Mane mushroom, also referred to as Hericium Erinaceus has been evidenced to have protective effects on alcohol induced hepatotoxicity and veisalgia (hangovers).5Lijun Hao, Yuxi Xie, Guikai Wu, Aibin Cheng, Xiaogang Liu, Rongjuan Zheng, Hong Huo, and Junwei Zhang, Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice, Evid Based Complement Alternat Med. 2015

This mushroom contains a few unique polysaccharide compounds, which have been proven to have remarkable water retention capacity.6Vikineswary Sabaratnam, Wong Kah-Hui, Murali Naidu, and Pamela Rosie David, Neuronal Health – Can Culinary and Medicinal Mushrooms Help?, J Tradit Complement Med. 2013

It also comprises active enzymatic compounds such as hericenones and erinacines which can cross the blood-brain barrier.7Puei-Lene Lai , Murali Naidu, Vikineswary Sabaratnam, Kah-Hui Wong, Rosie Pamela David, Umah Rani Kuppusamy, Noorlidah Abdullah, Sri Nurestri A Malek, Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia, Int J Med Mushrooms. 2013

All the aforementioned properties such as water-retention, and ability to cross blood-brain barrier makes Lion’s Mane mushroom a good remedy for hangover.

Freshcap Mushrooms provide the highest percentage of beta glucans and fruiting body nutrients, making this mushroom product my preferred choice for Lion’s Mane.


  • Clinically proven to increase Nerve Growth Factor synthesis
  • Can cross the blood-brain barrier
  • Boosts energy levels and sharpens focus
  • Suitable for Vegans/Vegetarians
  • Available in powder and pill form
  • Can be mixed in with meals and beverages


  • Can contain small amounts of toxins if not purchased from reputable sources

The Mushroom for Energy

Cordyceps Mushroom

  • Improve your stamina and energy levels

  • Helps improve your respiratory function and blood circulation

  • Potent anti-inflammatory and antioxidant effects

  • Helps ncrease the oxygen intake (VO2 max)

Cordyceps mushrooms are just one of the many natural options available for improving mental health. If you are looking for ways to reduce stress and anxiety or improve cognitive function, consider adding cordyceps mushrooms to your diet or supplement routine.

So, how do cordyceps mushrooms work for mental health and wellness?

These mushrooms contain compounds like cordycepin and polysaccharides which can help improve mental health by reducing stress and anxiety.

One of the main ways they do this is by helping to regulate the hormone cortisol. Cortisol is often referred to as the “stress hormone” as it is released when we are under stress.

Cordyceps also contains antioxidants that can protect the brain from damage caused by free radicals.

Studies show they can also help to improve cognitive function, memory, and focus while boosting energy levels. A recent study found that cordyceps improved memory and attention in a group of healthy adults. The study participants took either a placebo or cordyceps supplement for 12 weeks.

At the end of the study, those who had taken cordyceps showed significant improvements in memory and attention compared to those who took the placebo.

Cordyceps contains a few distinct bioactive amalgams which improve blood circulation, and enhance your body’s ability to more efficiently utilize oxygen, making it a key ingredient in your hangover recipe.8Bharat Kumar Pradhan, Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes): A Potential Bioresource for Commercialization in Sikkim Himalaya, India, Int J Med Mushrooms. 2016

Cordyceps has been found to support hepatic health and a few studies have shown that consuming cordyceps prior to drinking alcohol or getting high on any substance will help you to stay focused and alert.9Xuanwei Zhou , Zhenghua Gong, Ying Su, Juan Lin, Kexuan Tang, Cordyceps fungi: natural products, pharmacological functions and developmental products, J Pharm Pharmacol. 2009

Cordyceps will not only help you to reduce symptoms of the hangover quickly but will also help you get a better sleep afterwards.

Freshcap Mushrooms provide the highest percentage of beta glucans and fruiting body nutrients, making this mushroom product my preferred choice for Cordyceps.


  • Available in capsules and powder form
  • Can protect against health problems like asthma, depression, diabetes, fatigue, high cholesterol, and upper respiratory tract infections.
  • Has been shown to improve athletic performance and reduce fatigue.
  • All-natural


  • Quality cordyceps can be quite expensive and hard to find

Most Nootropics Per Serving

Qualia Mind

  • Improve focus, concentration, creativity and productivity

  • Increase mental dexterity and physical stamina

  • Sharpen memory

  • Enhance mood, sleep cycles and social skills

  • Alleviate the pain of a hangover

Qualia Mind is the most advanced nootropic formula on the market.

It includes 28 high-purity ingredients designed to maximize cognitive function.

Each component in isolation can make a significant impact on your neurochemistry.

When taken together, they display a powerful synergistic effect that can optimize vital neural pathways and processes.

The combined nootropic compounds, neuro-vitamins, amino acids, choline donors, and herbal adaptogens can help ease the pain of a hangover and restore your brain to optimal function.

This stack is great for anyone who needs a significant boost in brainpower.


  • Most advanced nootropic formula on the market
  • All-natural ingredients
  • Clean formula: No toxic fillers or necessary preservatives
  • Many positive user testimonials
  • Option for less potent Qualia Focus Available
  • Over 50% off 1st Bottle
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  • Large dose of 7 pills
  • More expensive than most other nootropics
  • More ingredients not always better.

Popular synthetic learning and memory aid


  • Helps with the recovery of your brain after one too many drinks

  • Helps clear up hangover symptoms like nausea, vomiting and general headaches

  • Is considered to be an excellent tool for preventing damage caused by traumatic brain injury

Any member of the racetam family may help with hangovers, but oxiracetam is particularly famous for its neuroprotective qualities.

Studies prove that it can protect the brain from traumatic brain injury. While nobody has done any studies regarding oxiracetam and hangovers, it would make sense that it would also help with alcohol-induced brain injury.

Hangover cures aren’t precisely the researcher’s biggest priority, which makes rigorous clinical evidence hard to come by.

But there are plenty of anecdotal reports that it can help the brain recover from a night out. And there is at least a solid theoretical basis for thinking it might be right.

The only real way to know is to try it out yourself.

Learn more about Oxiracetam for hangovers and other uses.

World’s #1 Selling Nootropic


  • Improves brain connectivity and helps with focus

  • Highly sustainable- no need for tolerance build up

  • Helps to avoid the sudden crashes you see with other drugs

  • Minimal side effects, can be taken every day

Noopept is the most popular nootropic on the market, and some users claim that it can ease the effects of heavy drinking.

Many nootropics enthusiasts will take it the night before to counteract the next day’s misery.

Again there is no clinical evidence that this is effective, but many people swear by it.

Read more about Noopept nootropic for hangovers and other symptoms.

Get more done in your day


  • Helps prevent headache/hangover

  • Builds memory

  • Reduces bad feelings like nausea and fatigue

If you are going to use one of the above racetams to help your hangover, you should also consider stacking it with a choline source like citicoline.

Oxiracetam or noopept will deplete your brain’s choline stores through their action, so it’s smart to fortify your brain with extra. Draining your choline can cause a headache, and you certainly don’t want that on top of whatever misery you’re already suffering.

Supplementing citicoline may also have some long term benefits for drinkers as well. Choline is necessary for forming and storing memories, something that alcohol is notorious for disrupting. Citicoline could help prevent this from happening.

There is also evidence that keeping your choline levels high can reduce the desire for drinking and drug use. So, citicoline may help curb your appetite for the substances that cause your hangover in the first place. 10Wignall, Brown. Citicoline in Addictive Disorders: A Review of the Literature, Am J Drug Alcohol Abuse 201411Rahman, Prendergast. Cholinergic receptor system as a target for treating alcohol abuse and dependence, Recent Patents In CNS Drug Discovery 2012

Learn More About Citicoline


  • Great choice for students or anyone looking to boost their cognitive performance
  • Improves focus, attention, and impulse control in people with ADHD
  • Generally well tolerated and side effects are rare.
  • All-natural supplement
  • Easily found online or in health food stores


  • May cause stomach upset, headache, dizziness, and insomnia

Powerful mood stabilizer
  • Treats the symptoms of hangovers

  • Decrease the severity of alcohol over time

  • Highly potent antioxidant that can scrub toxins from your body and brain

  • Can be used in hospitals to reverse acetaminophen overdose

NAC (N-acetyl L-cysteine) is a potent antioxidant that can scrub toxins from your body and brain. It is used in hospitals to reverse acetaminophen overdose, but can also treat the side-effects of alcohol use.

NAC contains the amino acid L-cysteine, which increases the antioxidant glutathione. Glutathione, in turn, binds to acetaldehyde and removes it from the body at a quicker rate.

Acetaldehyde is responsible for the worst symptoms of hangovers and can cause serious harm to your body long-term.

So, by clearing acetaldehyde out of the body, NAC can ultimately lessen the severity of alcohol toxicity. NAC also lowers the inflammation that drinking can cause. This process may allow you to feel better fast, as well as limit overall damage to your organs.12Mouret J, Lemoine P, Minuit MP, Robelin N. L-tyrosine cures, immediate and long term, dopamine-dependent depressions. Clinical and polygraphic studies, C R Acad Sci III. 1988

Learn More About NAC Nootropic

The all-natural “chill pill”


  • Take the edge off of caffeine’s jitteriness

  • Increases mood and focus

  • Boost productivity

One of the classic hangover cures is a hot cup of coffee.

While the caffeine may make you feel better, you can get an added benefit by stacking it with l-theanine.

L-theanine is a naturally occurring compound found in tea that can work synergistically with caffeine to improve mood and focus.

It is famous for taking the edge off of caffeine jitteriness.

If you need to power through a hangover and get work done, l-theanine and caffeine are your best friends.

The l-theanine will ensure that your coffee doesn’t overstimulate you and cause additional pain.

There is also evidence that taking l-theanine before drinking can reduce alcohol toxicity in mice. So, this nootropic may help you ward off the negative effects of overindulgence on either side of a big night out.13Sadzuka Y, et al. Effects of theanine on alcohol metabolism and hepatic toxicity, Biol Pharm Bull. 2005

Learn more about L-Theanine’s Benefits

Wrapping Up

The only surefire way to avoid a hangover is to practice moderation. But, if you’re dead set on letting the good times roll, you can at least pick up some of the nootropics on this list to ease the pain the morning after.

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Erik Abramowitz is a certified Nutritional Therapy Practitioner (NTP), Naturopathic Doctoral student, health coach, and father. He is the primary content creator for HolisticNootropics.com and the host of the Holistic Nootropics Podcast.

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