Testosterone is a man’s lifeline.
This one hormone single-handedly controls how you feel, how you perform, and your overall sense of joy in life.
It’s relatively common knowledge that boosting testosterone can optimize muscle growth and strength.
But its effects on mental health are even more profound.
These days testosterone is under assault from environmental toxins, poor diet, and chronic stress.
While there are plenty of doctors who can prescribe synthetic testosterone replacement, many men are wary of this option.
For those interested in a more natural, preventative approach, TestoLab Pro is a great option.
The following review goes deep into what TestoLab Pro is and how it can help you naturally raise testosterone for better mental and physical performance.
What Is TestoLab Pro T Booster?
TestoLab Pro is a testosterone enhancing supplement made from all-natural ingredients.
Years of research support the combination of these ingredients, to give you a superior product.
TestoLab Pro is free from caffeine, gluten, soy, allergens, synthetic additives, artificial coloring, artificial fillers, and preservatives.
It’s also non-irradiated, non-GMO, free of banned substances, and uses only GMP-certified ingredients.
Patented plant-based, prebiotic-enriched nutricaps cover each capsule for easy digestion.
The complete product is third-party tested by certified labs to ensure high-quality performance.
Its parent company, OptiNutra offers a 30-day risk-free, money-back guarantee, 24/7 customer support, and prompt, world-wide shipping.
TestoLab Pro also cares for the environment. They use only eco-friendly ingredients and recyclable packaging materials.
Low Testosterone and Mental Health
Low testosterone levels profoundly affect many aspects of cognitive performance as it influences the brain’s organizational and functional capabilities. 2Peter Celec, Daniela Ostatníková, and Július Hodosy, On the effects of testosterone on brain behavioral functions, Front Neurosci. 2015
The following examples highlight testosterone’s effects on mental health and cognition.
Testosterone and Brain Fog
Brain fog is a cognitive impairment that shows symptoms like lack of focus and concentration, forgetfulness, and hazy thought processes.3Anthony J. Ocon, Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome, Front Physiol. 2013
It is usually a result of chronic fatigue, but low testosterone levels worsen the situation.
Research highlights testosterone replacement therapy’s effectiveness in improving cognitive function, memory, and focus of men with Alzheimer’s disease and mild cognitive impairment. 4M M Cherrier 1, A M Matsumoto, J K Amory, S Asthana, W Bremner, E R Peskind, M A Raskind, S Craft, Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment, Neurology. 2005 5Hyun Jin Jung and Hong Seok Shin, Effect of Testosterone Replacement Therapy on Cognitive Performance and Depression in Men with Testosterone Deficiency Syndrome, World J Mens Health. 2016
Testosterone and Memory
Testosterone also plays a vital role in the memory and learning capacity of a person.
A study of older men with prostate cancer receiving androgen deprivation therapy showed lowered long-term and working memory impairment. 6AM M Cherrier 1, S Asthana, S Plymate, L Baker, A M Matsumoto, E Peskind, M A Raskind, K Brodkin, W Bremner, A Petrova, S LaTendresse, S Craft, Testosterone supplementation improves spatial and verbal memory in healthy older men, Neurology. 2001
Testosterone administration, on the other hand, produced the opposite result. Subjects given testosterone supplementation showed improved cognitive functions, including spatial and verbal memory. 7M M Cherrier , S Asthana, S Plymate, L Baker, A M Matsumoto, E Peskind, M A Raskind, K Brodkin, W Bremner, A Petrova, S LaTendresse, S Craft, Testosterone supplementation improves spatial and verbal memory in healthy older men, Neurology. 2001
Similar results have also been observed in men with Alzheimer’s disease experiencing mild cognitive impairment.8M M Cherrier , A M Matsumoto, J K Amory, S Asthana, W Bremner, E R Peskind, M A Raskind, S Craft, Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment, Neurology. 2005 9Jeremy T. Hua, MD, Kerry L. Hildreth, MD, and Victoria S. Pelak, MD, Effects of Testosterone Therapy on Cognitive Function in Aging: A Systematic Review, Cogn Behav Neurol. 2016
Even healthy men benefit from testosterone supplementations and display significant improvement in their spatial and verbal memory.10M M Cherrier 1, A M Matsumoto, J K Amory, M Johnson, S Craft, E R Peskind, M A Raskind, Characterization of verbal and spatial memory changes from moderate to supraphysiological increases in serum testosterone in healthy older men, Psychoneuroendocrinology. 2007
Testosterone and Depression and Anxiety
Testosterone demonstrates a strong potential to protect men against anxiety and depression 11Jenna McHenry , Nicole Carrier , Elaine Hull , Mohamed Kabbaj , Sex differences in anxiety and depression: role of testosterone, Neuroendocrinol. 2014 , while also showing an antidepressant effect.12FA Zarrouf, S Artz, J Griffith, C Sirbu, and M Kommor, Testosterone and depression: systematic review and meta-analysis, Centre for Reviews and Dissemination (UK); 1995 13Harrison G Pope Jr 1, Geoffrey H Cohane, Gen Kanayama, Arthur J Siegel, James I Hudson, Testosterone gel supplementation for men with refractory depression: a randomized, placebo-controlled trial, Am J Psychiatry. 2003
Low testosterone levels show a strong correlation in regards to depression in hypogonadal (diminished testes function) men. 14Andreas Walther, PhD,corresponding author, Jonas Breidenstein, BSc, and Robert Miller, PhDcorresponding author, Association of Testosterone Treatment With Alleviation of Depressive Symptoms in Men, JAMA Psychiatry. 2019 15Mohit Khera, Patients with testosterone deficit syndrome and depression, Arch Esp Urol. 2013
This relation happens because testosterone secretion responds to various stimuli, including social behavior demonstrating low levels of this hormone resulting in depression and other behavioral changes.16Farzan Kheirkhah, MD, Seyed Reza Hosseini, Seyyedeh Fatemeh Hosseini, MD, Nafiseh Ghasemi, DDS,1 Ali Bijani, MD, and Robert G. Cumming, MD, PhD, Relationship between testosterone levels and depressive symptoms in older men in Amirkola, Iran, Caspian J Intern Med. 2014
Clinical trials have proven that testosterone replacement therapy improves the symptoms of depression, anxiety, and irritability. 17Stuart N Seidman, Testosterone deficiency and mood in aging men: pathogenic and therapeutic interactions, World J Biol Psychiatry. 2003
Testosterone and Aggression/Anger
Increasing testosterone also works well in managing anger, nervousness, and irritability.
Subjects undergoing testosterone replacement therapy (TRT) display improved energy levels, friendliness, and general well being.18C Wang , G Alexander, N Berman, B Salehian, T Davidson, V McDonald, B Steiner, L Hull, C Callegari, R S Swerdloff, Testosterone replacement therapy improves mood in hypogonadal men–a clinical research center study, J Clin Endocrinol Metab. 1996
It is essential to note, though, the importance of supervised use of testosterone supplements.
Testo Lab Pro Cognitive Benefits
Testo Lab Pro comes with many cognitive benefits.
For many men, this all-natural formula works similarly to a nootropic.
Testosterone levels naturally lower with age.
Other causative factors of low testosterone levels include a poor diet, environmental toxicity, medications, alcohol abuse, and other medical conditions. 20Jordan Cohen, Daniel E. Nassau, Premal Patel, and Ranjith Ramasamy, Low Testosterone in Adolescents & Young Adults, Front Endocrinol (Lausanne). 2019
Low testosterone levels directly affect the body and mental functions of a man.21Liverman CT, Blazer DG, Testosterone and Aging: Clinical Research Directions., National Academies Press (US); 2004 But supplementation effectively increases testosterone levels.
Testosterone enhancement comes in different forms, and each has its pros and cons. However, oral forms give the lowest risks, offer more convenience, and are easier to discontinue when you feel any discomfort. 22Roger D Stanworth and T Hugh Jones, Testosterone for the aging male; current evidence and recommended practice, Clin Interv Aging. 2008
Medical practitioners recommend thorough monitoring every three months, especially if there are underlying conditions that may influence the treatment’s efficacy.
Testosterone demonstrates a dampening effect on elevated levels of the stress hormone cortisol. 23Matthew S. Panizzon, Richard L. Hauger, Hong Xian, Kristen Jacobson, Michael J. Lyons, Carol E. Franz, and William S. Kremen, Interactive Effects of Testosterone and Cortisol on Hippocampal Volume and Episodic Memory in Middle-Aged Men, Psychoneuroendocrinology. 2018
Stress can cause energy depletion leading to loss of sleep, fatigue, and other depressive symptoms.
Testosterone helps by increasing serotonin levels in the blood 24Georg S. Kranz, Wolfgang Wadsak, Ulrike Kaufmann, Markus Savli, Pia Baldinger, Gregor Gryglewski, Daniela Haeusler, Marie Spies, Markus Mitterhauser, Siegfried Kasper, and Rupert Lanzenbergera, High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People, Biol Psychiatry. 2015 which stabilizes mood, well-being, and positive attitude.
Low libido and low testosterone levels have a strong correlation among older men. Evidence shows positive responses in terms of sexual drive and activity after receiving testosterone treatment. 25Glenn R Cunningham , Alisa J Stephens-Shields , Raymond C Rosen , Christina Wang , Shalender Bhasin , Alvin M Matsumoto , J Kellogg Parsons , Thomas M Gill , Mark E Molitch 1, John T Farrar , David Cella , Elizabeth Barrett-Connor , Jane A Cauley , Denise Cifelli , Jill P Crandall , Kristine E Ensrud , Laura Gallagher , Bret Zeldow , Cora E Lewis , Marco Pahor , Ronald S Swerdloff , Xiaoling Hou , Stephen Anton , Shehzad Basaria , Susan J Diem , Vafa Tabatabaie , Susan S Ellenberg , Peter J Snyder , Testosterone Treatment and Sexual Function in Older Men With Low Testosterone Levels, J Clin Endocrinol Metab. 2016
Studies have also shown that oral testosterone derivatives significantly increase sexual interest and behavior. 26N E Skakkebaek, J Bancroft, D W Davidson, P Warner, Androgen replacement with oral testosterone undecanoate in hypogonadal men: a double blind controlled study, Clin Endocrinol (Oxf). 1981
Mental Clarity and Sharpness
We often try to avoid stress, but research presented compelling evidence that high cortisol (the primary stress hormone) levels proportionately affect the testosterone and the hippocampus, the part of the brain that governs learning. 27Matthew S. Panizzon, Richard L. Hauger, Hong Xian,Kristen Jacobson, Michael J. Lyons, Carol E. Franz,and William S. Kremen, Interactive Effects of Testosterone and Cortisol on Hippocampal Volume and Episodic Memory in Middle-Aged Men, Psychoneuroendocrinology. 2018
The same study underlined testosterone’s moderating effect on cortisol and how it protects the brain when cortisol levels approach unhealthy levels.
This moderating effect of testosterone helps preserve memory performance for better clarity.
Mental fortitude is a combination of attributes like emotion control, confidence, fast recovery from failures, and visualization of goals. A positive mindset is a must to achieve these attributes. 28Joanna S. Zeiger, Robert S. Zeiger, Mental toughness latent profiles in endurance athletes, PLoS One. 2018
Older men receiving testosterone replacement therapy showed better mood and decreased anger, irritability, and depression,29Vineet Tyagi, MD, Michael Scordo, MD, Richard S. Yoon, MD,1 Frank A. Liporace, MD,and Loren Wissner Greene, MD, Revisiting the role of testosterone: Are we missing something?, Rev Urol. 2017 essential in maintaining mental fortitude.
Many high performers tout the benefits of stoicism.
Stoicism is the ability to persevere through obstacles and finding meaning in life even while surrounded by negativity.
Sufficient testosterone levels help foster this mindset and keep you on the path to success.
Confidence and Swagger
“When you have confidence, you can have a lot of fun. And when you have fun, you can do amazing things.” – Joe Namath
As a man, nothing is more important than confidence.
It’s what gives you that push to accomplish goals, defy the odds, and just be an all-around bad-a$$.
For many men, that extra boost of testosterone is what gives you the edge to feel confident and carry yourself with an extra sense of accomplishment.
Especially for anyone who’s competitive, confidence is everything.
In a study among athletes, actors, and ministers, results showed that competitive people have higher confidence and testosterone levels. 30James M Dabbs , Denise de la Rue, Paula M Williams, Testosterone and occupational choice: actors, ministers, and other men, J Pers Soc Psychol. 1990
Anyone looking to get ahead in life needs this competitive edge. To survive the rigors of competition and outlast your opponents you must have a high level of confidence which calls for sufficient levels of testosterone. 31Christoph Eisenegger , Robert Kumsta , Michael Naef , Jörg Gromoll , Markus Heinrichs, Testosterone and androgen receptor gene polymorphism are associated with confidence and competitiveness in men, Horm Behav. 2017
Even if you’re not competitive, boosting testosterone gives you a sense of feeling like a winner that can boost your all-around mood. 32Ruth I. Wood1 and Steven J. Stanton, TESTOSTERONE AND SPORT: CURRENT PERSPECTIVES, Horm Behav. 2012
TestoLab Pro Physical Benefits Benefits
Testo Lab Pro’s physical benefits are just as impressive as its cognitive benefits.
Below are just some of the many physical benefits that come from supplementing with this all-natural testosterone booster.
Muscle Strength and Size
Muscle strength and size are proportionately related to testosterone levels, as observed in older men with weakened muscle strength. 33Upendram Srinivas-Shankar , Stephen A Roberts, Martin J Connolly, Matthew D L O’Connell, Judith E Adams, Jackie A Oldham, Frederick C W Wu, Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study, J Clin Endocrinol Metab. 2010 34R N Baumgartner 1, D L Waters, D Gallagher, J E Morley, P J Garry, Predictors of skeletal muscle mass in elderly men and women, Mech Ageing Dev. 1999
The oral testosterone administration resulted in increased muscle mass, further giving testosterone importance in maintaining muscle mass and strength in elderly subjects. 35You-Seon Nam, Gyeongsil Lee, Jae Moon Yun, and Belong Cho, Testosterone Replacement, Muscle Strength, and Physical Function, World J Mens Health. 2018
Testosterone supplementation enhancement can help erectile function in some cases.
It’s important to note that most cases of erectile dysfunction come from other complicating factors like blood flow and cardiovascular issues.
However, testosterone supplementation shows potential as an adjunct therapy for erectile dysfunction with aggravating conditions such as diabetes and other metabolic disorders. 36R Shabsigh , J Rajfer, A Aversa, A M Traish, A Yassin, S Y Kalinchenko, J Buvat, The evolving role of testosterone in the treatment of erectile dysfunction, Int J Clin Pract. 2006
There are even studies showing castrated men with overtly low testosterone levels experienced improved frequency and rigidity of erections, 37Jacob Rajfer, MD, Relationship Between Testosterone and Erectile Dysfunction, Rev Urol. 2000 sexual function, and satisfaction after undergoing testosterone supplementation. 38A Morales , B Johnston, J P Heaton, M Lundie, Testosterone supplementation for hypogonadal impotence: assessment of biochemical measures and therapeutic outcomes, J Urol. 1997 39R Shabsigh 1, J Rajfer, A Aversa, A M Traish, A Yassin, S Y Kalinchenko, J Buvat, The evolving role of testosterone in the treatment of erectile dysfunction, Int J Clin Pract. 2006
Low testosterone leads to fat gain, and fat gain causes low testosterone levels. 40Mark Ng Tang Fui, Philippe Dupuis, and Mathis Grossmann, Lowered testosterone in male obesity: mechanisms, morbidity and management, Asian J Androl. 2014 41E J Hamilton , E Gianatti, B J Strauss, J Wentworth, D Lim-Joon, D Bolton, J D Zajac, M Grossmann, Increase in visceral and subcutaneous abdominal fat in men with prostate cancer treated with androgen deprivation therapy, Clin Endocrinol (Oxf). 2011
Higher cortisol that is seen in obesity also promotes fat deposition.
Testosterone supplementation can be a game-changer for slowing and even reversing weight issues.43Gary A Wittert , Ian M Chapman, Matthew T Haren, Shylie Mackintosh, Penelope Coates, John E Morley, Oral testosterone supplementation increases muscle and decreases fat mass in healthy elderly males with low-normal gonadal status, J Gerontol A Biol Sci Med Sci. 2003 44Abdulmaged M. Traish, Testosterone and weight loss: the evidence, Curr Opin Endocrinol Diabetes Obes. 2014
Many factors influence sexual function, but evidence shows the potential of testosterone treatment in improving libido and erectile dysfunction. 45Samantha Huo, Anthony R. Scialli, Sean McGarvey, Elizabeth Hill, Buğra Tügertimur, Alycia Hogenmiller, Alessandra I. Hirsch, and Adriane Fugh-Berman, Treatment of Men for “Low Testosterone”: A Systematic Review, PLoS One. 2016
Testosterone supplementation is essential, especially in older men, as testosterone plays a vital role in male sexual desire, sex thoughts, reaction to sexual stimuli, and sexual activity. 46Jae Hung Jung, Hong Wook Kim, Vikram Narayan, Balaji Reddy, Thomas Walsh, Ho Song Yu, Jung Soo Lim, Myung Ha Kim, and Philipp Dahm, Testosterone supplementation in men with sexual dysfunction, Cochrane Database Syst Rev. 2018
Most testosterone supplements on the market are filled with synthetic, toxic ingredients that leave much to be desired.
Testo Lab Pro’s formula is truly remarkable in that it uses only natural, scientifically-proven ingredients without any added fillers.
This is what makes it my top choice as a testosterone booster.
KSM 66 Ashwagandha
Ashwagandha (Withania somnifera) has confirmed anxiolytic, neurological, anti-inflammatory, and antioxidant effects. 47Adrian L. Lopresti, PhD, Stephen J. Smith, MA,a,b Hakeemudin Malvi, MBBS, MD,c and Rahul Kodgule, MBBSd, An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract, Medicine (Baltimore). 2019
It influences sex hormone production, improves muscle strength and endurance, has mood-enhancing properties, and moderates cortisol and stress-causing hormones in the body.
Studies on the effectiveness of velvet beans (Mucuna pruriens) show improved testosterone levels leading to stress reduction and improved semen quality. 48Kamla Kant Shukla, Abbas Ali Mahdi, Mohammad Kaleem Ahmad, Shyam Pyari Jaiswar, Satya Narain Shankwar, and Sarvada Chandra Tiwari, Mucuna pruriens Reduces Stress and Improves the Quality of Semen in Infertile Men, Evid Based Complement Alternat Med. 201 49Akhand Pratap Singh, Saumya Sarkar, Muktanand Tripathi, and Singh Rajender, Mucuna pruriens and Its Major Constituent L-DOPA Recover Spermatogenic Loss by Combating ROS, Loss of Mitochondrial Membrane Potential and Apoptosis , PLoS One. 2013
Mucuna pruriens also shows neuroprotective benefits and potential to treat Parkinson’s disease, a degenerative disease that impairs a person’s motor and mental skills. 50Lucia Raffaella Lampariello, Alessio Cortelazzo, Roberto Guerranti, Claudia Sticozzi, and Giuseppe Valacchi, The Magic Velvet Bean of Mucuna pruriens, J Tradit Complement Med. 2012
Luteolin is a flavone found in parsley, thyme, and celery and works well in supporting steroidogenesis supporting testosterone production. 51Luc J. Martin1, and Mohamed Touaibia, Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism, Antioxidants (Basel). 2020 52Roxanne Couture 1, Nathalie Mora 2, Sheiraz Al Bittar 2, Mustapha Najih 1, Mohamed Touaibia 3, Luc J Martin , Luteolin modulates gene expression related to steroidogenesis, apoptosis, and stress response in rat LC540 tumor Leydig cells, Cell Biol Toxicol. 2020
Luteolin also helps to clear brain fog, improves cognitive functions in dementia and Alzheimer’s disease, and helps manage various health issues caused by obesity and other metabolic problems. 53Theoharis C. Theoharides, Julia M. Stewart, Erifili Hatziagelaki, and Gerasimos Kolaitis, Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin, Front Neurosci. 2015
D- Aspartic Acid
D-Aspartic acid is a non-essential amino acid known for its role in the central nervous system 54Nobutoshi Ota, Ting Shi, and Jonathan V. Sweedler D-aspartate acts as a signaling molecule in nervous and neuroendocrine systems, Amino Acids. 2012 and hormone production (testosterone included). 55Enza Topo, Andrea Soricelli, Antimo D’Aniello, Salvatore Ronsini, and Gemma D’Aniello, The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats, Reprod Biol Endocrinol. 2009
Male fertility 56Gemma D’Aniello , Salvatore Ronsini, Francesco Guida, Patrizia Spinelli, Antimo D’Aniello, Occurrence of D-aspartic acid in human seminal plasma and spermatozoa: possible role in reproduction, Fertil Steril. 2005 and neuropsychological conditions like schizophrenia 57Francesco Errico, Tommaso Nuzzo,2 Massimo Carella,2 Alessandro Bertolino,3 and Alessandro Usiello, The Emerging Role of Altered d-Aspartate Metabolism in Schizophrenia: New Insights From Preclinical Models and Human Studies, Front Psychiatry. 2018 also benefit from d-aspartic acid.
Zinc is an essential mineral known for its potential in modulating serum testosterone levels in men. 58A S Prasad , C S Mantzoros, F W Beck, J W Hess, G J Brewer, Zinc status and serum testosterone levels of healthy adults, Nutrition. 1996
Zinc treatment promotes spermatogenesis in men with low testosterone levels. 59Yan-Ling Liu, Man-Na Zhang, Guo-Yu Tong, Shou-Yue Sun, Yan-Hua Zhu,Ying Cao, Jie Zhang, Hong Huang, Ben Niu, Hong Li, Qing-Hua Guo, Yan Gao, Da-Long Zhu, Xiao-Ying Li, The effectiveness of zinc supplementation in men with isolated hypogonadotropic hypogonadism, Asian J Androl. 2017
Research also shows low zinc levels in patients diagnosed with psychiatric disorders 60Ole Grønli, Jan Magnus Kvamme, 1 Oddgeir Friborg,and Rolf Wynn, Zinc Deficiency Is Common in Several Psychiatric Disorders, PLoS One. 2013 and their role in treating psychosis and depression. 61Matthew A. Petrilli, Thorsten M. Kranz, Karine Kleinhaus, Peter Joe, Mara Getz, Porsha Johnson, Moses V. Chao, and Dolores Malaspina, The Emerging Role for Zinc in Depression and Psychosis, Front Pharmacol. 2017
Boron is an essential trace mineral necessary for your body’s use of testosterone and estrogen. One study proved that boron supplementation increased free testosterone levels. 62Lara Pizzorno, MDiv, MA, LMT, Nothing Boring About Boron, Integr Med (Encinitas). 2015
Another study documented the negative effect of boron deprivation on motor speed, agility, attention, and short-term memory. 63James G. Penland, The importance of boron nutrition for brain and psychological function, Biological Trace Element Research volume. 1998
Magnesium increases the bioactivity of testosterone by minimizing oxidative stress in the body. 64M. Maggio,G. P. Ceda, F. Lauretani, C. Cattabiani, E. Avantaggiato, S. Morganti, F. Ablondi, S. Bandinelli,L. J. Dominguez, M. Barbagallo, G. Paolisso, R. D. Semba, and L. Ferrucci, Magnesium and anabolic hormones in older men, Int J Androl. 2011
This finding shows the potential of magnesium and testosterone supplementation to improve physical and mental performance. 65Marcello Maggio, Francesca De Vita, Fulvio Lauretani, Antonio Nouvenne, Tiziana Meschi, Andrea Ticinesi, Ligia J. Dominguez, Mario Barbagallo, Elisabetta Dall’Aglio, and Gian Paolo Ceda, The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men, Int J Endocrinol. 2014
Magnesium also demonstrates positive effects on mental disorders such as bipolar disorder, schizophrenia, obsessive-compulsive disorder, autism, anxiety disorder, and eating disorders like bulimia and anorexia nervosa. 66Andrea Botturi,Valentina Ciappolino, Giuseppe Delvecchio, Andrea Boscutti, Bianca Viscardi, and Paolo Brambilla, The Role and the Effect of Magnesium in Mental Disorders: A Systematic Review, Nutrients. 2020 67Neil Bernard Boyle, Clare Lawton, and Louise Dye, The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review, Nutrients. 2017
It is also essential in the proper functioning of the central nervous system. 68Anna E. Kirkland, Gabrielle L. Sarlo, and Kathleen F. Holton, The Role of Magnesium in Neurological Disorders, Nutrients. 2018
Sufficient evidence from studies reveals the relationship between low vitamin D levels and hypogonadism in men with a mean age of 53 69Ningjian Wang, Bing Han, Qin Li, Yi Chen, Yingchao Chen, Fangzhen Xia, Dongping Lin, Michael D. Jensen,corresponding author and Yingli Lu, Vitamin D is associated with testosterone and hypogonadism in Chinese men: Results from a cross-sectional SPECT-China study, Reprod Biol Endocrinol. 2015 and that vitamin D supplementation can increase testosterone levels. 70S Pilz , S Frisch, H Koertke, J Kuhn, J Dreier, B Obermayer-Pietsch, E Wehr, A Zittermann, Effect of vitamin D supplementation on testosterone levels in men, Horm Metab Res. 2011
Vitamin D deficiency also increases the chances of mental disorders, as exhibited by a few studies on psychiatric health patients. 71S. Ristic, S.S. Kocic, D.R. Milovanovic, G. Mihajlovic, N. Mihailovic, A.T. Lucic, and S. Zivanovic, VITAMIN D STATUS IN PATIENTS WITH MENTAL DISORDERS: A CROSS-SECTIONAL ANALYSIS OF SINGLE COHORT FROM ROUTINE PRACTICE, Acta Endocrinol (Buchar). 2017 72Alessandro Cuomo, Giuseppe Maina, Simone Bolognesi, Gianluca Rosso, Bruno Beccarini Crescenzi, Francesco Zanobini, Arianna Goracci, Edvige Facchi, Ettore Favaretto, Irene Baldini, Aurora Santucci, and Andrea Fagiolini, Prevalence and Correlates of Vitamin D Deficiency in a Sample of 290 Inpatients With Mental Illness, Front Psychiatry. 2019
Vitamins K1, K2
Clinical trials have positively identified low levels of vitamin K as one of the culprits of low testosterone production, 73Hitoshi Shirakawa , Yusuke Ohsaki, Yoshihiko Minegishi, Naofumi Takumi, Kousaku Ohinata, Yuji Furukawa, Takeo Mizutani, Michio Komai, Vitamin K deficiency reduces testosterone production in the testis through down-regulation of the Cyp11a a cholesterol side chain cleavage enzyme in rats, Biochim Biophys Acta. 2006 and supplementation can reverse this effect. 74Naofumi Takumi , Hitoshi Shirakawa, Yusuke Ohsaki, Asagi Ito, Takaya Watanabe, Puspo E Giriwono, Toshiro Sato, Michio Komai, , Food Funct. 2011
In multiple studies, subjects with low levels of vitamin K displayed increases in depression, 75Francesco Bolzetta, Nicola Veronese, Brendon Stubbs, Marianna Noale,2 Alberto Vaona, Jacopo Demurtas, Stefano Celotto, Chiara Cacco, Alberto Cester, Maria Gabriella Caruso, Rosa Reddavide, Maria Notarnicola, Stefania Maggi, Ai Koyanagi, Michele Fornaro, Joseph Firth, Lee Smith, and Marco Solm, The Relationship between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: A Cross-Sectional Analysis from a Large Cohort Study, Nutrients. 2019 and early-onset Alzheimer’s disease.76Nancy Presse , Bryna Shatenstein, Marie-Jeanne Kergoat, Guylaine Ferland, Low vitamin K intakes in community-dwelling elders at an early stage of Alzheimer’s disease, J Am Diet Assoc. 2008
On the other hand, high levels of vitamin K lead to improved memory. 77Justine Chouet , Guylaine Ferland , Catherine Féart , Yves Rolland , Nancy Presse , Kariane Boucher , Pascale Barberger-Gateau , Olivier Beauchet , Cedric Annweiler, Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study, Nutrients. 2015 78 Nancy Presse , Sylvie Belleville, Pierrette Gaudreau, Carol E Greenwood, Marie-Jeanne Kergoat, Jose A Morais, Hélène Payette, Bryna Shatenstein, Guylaine Ferland, Vitamin K status and cognitive function in healthy older adults, Neurobiol Aging. 2013
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