As a nutritional therapy practitioner, I always look for the best nootropics to recommend to my clients.
After months of research and testing, I stumbled across NSI-189.
To learn more about NSI-189, I looked at factors such as safety, effectiveness, and cost and found this product to be an excellent option for the right person.
By reading this article, you will learn why NSI-189 is one of the best nootropics on the market today.
You’ll also get an in-depth look at how it works in your body and how NSI-189 can benefit your cognitive health.
Plus, you’ll get tips on how to use it safely and effectively to maximize its benefits.
So if you’re looking for a safe and effective nootropic to help improve your cognitive health, this article is for you!
Let’s dive in and take a closer look at NSI-189!
Where To Buy NSI-189 Phosphate
Proven neurogenic capabilities –> New brain cells
Shown to ameliorate depressive symptoms
Save 10% when using code HolisticNootropics @ Checkout
Safe and generally well-tolerated
What Is NSI-189?
NSI-189 is a proprietary new chemical created by Neuralstem, Inc. (NYSE Amex: CUR). It is a novel benzylpiperizine-aminiopyridine nootropic that has been shown to offer multiple cognitive benefits, including mood boosts, improved memory and focus, neuroprotection, neurogenesis, greater clarity of thought, and quicker reaction times.1M Fava et al, A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patientsMolecular Psychiatry 2016
Since its discovery as an agent of neurogenesis of human hippocampus-derived neural stem cells in vitro and in vivo, research into NSI-189 has discovered its role in overall cognitive enhancement.2Roger S McIntyre et al, The neurogenic compound, NSI-189 phosphate: a novel multi-domain treatment capable of pro-cognitive and antidepressant effectsExpert Opin Investig Drugs. 2017
Questions still surround whether NSI-189 exerts neurogenic effects in brain regions outside of the hippocampus or subventricular zone and whether there are stimulatory effects on glial populations.
Regardless, NSI-189 has proven its ability to boost various metrics of cognition in human and animal randomized controlled trials and in mechanistic data in-vitro trials.
NSI-189 Cognitive Benefits
All discussion of NSI-189’s benefits begin and end with its neurogenic abilities as it is a potent stimulator of neural stem cells in the hippocampus.3G. I. Papakostas et al, A phase 2, double-blind, placebo-controlled study of NSI-189 phosphate, a neurogenic compound, among outpatients with major depressive disorder molecular psychiatry. 2019
This phenomenon has been observed in human, animal, and in-vitro studies.
This process is considered one of the main ways that nootropics like NSI-189 can improve cognitive function and neuroplasticity.
In addition, patients treated with NSI-189 also showed increases in hippocampal volume and neural progenitor cell proliferation within the dentate gyrus region of the hippocampus.
These results suggest that neuronal plasticity and neurogenesis are at least partially responsible for the therapeutic effects of this novel nootropic.4M Fava et al, A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patientsMol Psychiatry. 2016
Additionally, subjects performed better on various behavioral and cognitive tests when compared to control given given only saline solution or placebo.
Overall, multiple studies have shown that NSI-189 can stimulate neurogenesis and increase hippocampal volume in both humans and animals, suggesting that it may play a role in improving cognitive functions such as memory and learning
It’s believed that loss of neurogenesis in the hippocampus is one of the physiological symptoms of major depressive disorder (MDD).5Gianluca Serafini, Neuroplasticity and major depression, the role of modern antidepressant drugsWorld J Psychiatry. 2012
Multiple randomized, placebo-controlled trials have demonstrated and replicated NSI-189’s ability to alleviate MDD symptoms through neurogenesis.6M Fava et al, A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patientsMol Psychiatry. 20167G I Papakostas et al, A phase 2, double-blind, placebo-controlled study of NSI-189 phosphate, a neurogenic compound, among outpatients with major depressive disorderMol Psychiatry. 2020
It’s believed that NSI-189 may have neuroprotective qualities against Alzheimer’s due to a 2019 study where 12 weeks of oral treatment with NSI-189 at 30 mg/kg significantly reversed learning and memory deficits in mice bred with tau and amyloid precursor protein (TAPP). 8Corinne G. Jolivalt et al, P2-067: EFFECTS OF THE NEUROGENIC MOLECULE NSI-189 ON INDICES OF COGNITION IN AN APP/TAU MOUSE MODEL OF ALZHEIMER’S DISEASEAAIC. 2019
Memory and learning enhancements may significantly benefit from enhanced hippocampal plasticity from NSI-189 treatment. 9Yan Liu et al, Enhancement of synaptic plasticity and reversal of impairments in motor and cognitive functions in a mouse model of Angelman Syndrome by a small neurogenic molecule, NSI-189Neuropharmacology. 2019
One study showed NSI-189 produced a time- and dose-dependent increase in the magnitude of long-term potentiation (LTP) is the primary experimental model for investigating learning and memory capabilities at the synaptic level. 10T. V. P. Bliss & G. L. Collingridge , A synaptic model of memory: long-term potentiation in the hippocampusNature 1993
A 2022 16-week study in diabetic rats showed NSI-189 enhanced mitochondrial function in the peripheral and central nervous systems, ameliorating impaired memory function and neural plasticity.11C G Jolivalt et al, Enhancement of Mitochondrial Function by the Neurogenic Molecule NSI-189 Accompanies Reversal of Peripheral Neuropathy and Memory Impairment in a Rat Model of Type 2 DiabetesJ Diabetes Res. 2022
Brain remodeling post-stroke may be NSI-189’s most impactful potential benefit.
While not extensively studied, there is some evidence that NSI augments endogenous repair mechanisms by increasing cell proliferation and neuronal lineage commitment in discreet neurogenic niches and non‐neurogenic brain regions due to its neurogenic properties shown both in vivo and in-vitro. 12Naoki Tajiri, NSI‐189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats J Cell Physiol. 2017
Even better, these experiments demonstrated NSI-189’s continued functional post-stroke brain improvements after discontinuing the treatment via the abovementioned mechanisms.
NSI-189 is generally safe and well-tolerated with no serious adverse events reported
In conclusion, NSI-189 is a powerful and safe nootropic with multiple cognitive benefits. Studies have found that it can stimulate neurogenesis and increase hippocampal volume, which may offer a way to reverse some of the effects of Alzheimer’s disease and major depressive disorder. On top of this, it can also help improve memory, focus, and clarity of thought. For these reasons, NSI-189 is quickly becoming one of the most popular nootropics today.