Noopept: Benefits, Dosing, Where To Buy, And More!

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Key Information

Noopept is a powerful nootropic:

Noopept is a synthetic supplement that enhances memory, cognition, learning, mood, and perception.

Noopept works by modulating neurotransmitters:

Noopept increases acetylcholine and glutamate, which are important for brain function, and protects against oxidative damage.

Noopept has multiple benefits for the brain:

Noopept improves focus, attention, recall, stress resistance, and neuroplasticity, and may prevent cognitive decline.

Noopept is safe and easy to use:

Noopept has few side effects, a low dose, and a fast onset of action, and is legal and affordable.

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Noopept, a popular nootropic compound developed in Russia, has gained significant attention for its potential cognitive-enhancing effects. At, we believe in a comprehensive, evidence-based approach to optimizing mental performance and well-being.

In this ultimate guide, we’ll dive deep into the world of Noopept, exploring its origins, mechanisms of action, benefits, dosage recommendations, and more. Our goal is to provide you with the knowledge and tools to make informed decisions about incorporating Noopept into your holistic cognitive enhancement regimen.

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What is Noopept?

Noopept, scientifically known as N-phenylacetyl-L-prolylglycine ethyl ester, is a synthetic nootropic compound derived from the racetam family. Although structurally similar to piracetam, Noopept has a distinct chemical composition that sets it apart.

Developed in Russia in the 1990s, Noopept has been studied for its potential cognitive-enhancing properties and neuroprotective effects.

Compared to other nootropics like piracetam, Noopept is considered to be more potent, with a recommended dosage range of 10-30 mg per day. Its unique chemical structure allows for better bioavailability and faster absorption in the body, making it an attractive option for those seeking cognitive support.

How Does Noopept Work?

Noopept’s mechanisms of action in the brain are multifaceted and complex. Research suggests that Noopept works by:

  • Modulating AMPA and NMDA receptors, which are involved in learning and memory processes[1]
  • Enhancing acetylcholine transmission, a neurotransmitter crucial for cognitive function[1]
  • Providing neuroprotective effects by reducing oxidative stress and inflammation in the brain[1]

Moreover, Noopept has been shown to increase the expression of Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF), two essential proteins that support the growth, survival, and plasticity of neurons.[2]

By promoting neuroplasticity and long-term potentiation, Noopept may contribute to enhanced cognitive performance and brain health.

Benefits of Noopept

The potential benefits of Noopept are wide-ranging and may include:

  • Improved cognitive function and mental clarity
  • Enhanced memory and learning abilities[3]
  • Increased focus and concentration
  • Potential anxiolytic (anti-anxiety) effects[4]
  • Neuroprotective properties, potentially mitigating age-related cognitive decline[5]

It’s important to note that individual results may vary, and more research is needed to fully understand the long-term effects of Noopept on cognitive performance and brain health.

Noopept Dosage and Administration

The recommended dosage range for Noopept is typically between 10-30 mg per day. Noopept is available in various forms, including powder, capsules, and sublingual tablets. When starting with Noopept, it’s crucial to begin with a low dose and gradually increase as needed, carefully monitoring your body’s response.

Optimal timing and frequency of dosing may vary depending on individual factors and desired outcomes. Some users prefer to take Noopept in divided doses throughout the day, while others find a single daily dose effective. Experimentation and tracking your personal response can help determine the most suitable regimen for your needs.

Noopept vs. Other Nootropics

Noopept is often compared to other popular nootropics, particularly those in the racetam family. While Noopept shares some similarities with compounds like piracetam, aniracetam, and oxiracetam, it also possesses unique characteristics that set it apart:

  • Higher potency: Noopept is considered to be more potent than piracetam, with effective doses ranging from 10-30 mg per day, compared to the gram-scale doses typically used for piracetam.
  • Better bioavailability: Noopept’s chemical structure allows for better absorption and faster uptake in the body, potentially leading to more rapid effects.
  • Distinct mechanisms of action: While Noopept and other racetams may share some common pathways, Noopept’s effects on NGF, BDNF, and other neurotransmitter systems may contribute to its unique cognitive-enhancing properties.
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Potential Side Effects and Precautions

Noopept is generally well-tolerated, but some users may experience side effects, particularly at higher doses or with prolonged use. Potential side effects may include:

  • Headaches
  • Irritability
  • Brain fog
  • Sleep disturbances

To minimize the risk of side effects, it’s essential to start with a low dose, monitor your response, and cycle Noopept as needed. If you have pre-existing medical conditions or are taking medications, consult with a healthcare professional before starting Noopept or any other nootropic supplement.

Stacking Noopept with Other Nootropics

Noopept can be combined with other nootropics to create synergistic effects and target specific cognitive needs. Popular Noopept stacks include:

  • Noopept + Choline source (e.g., Alpha-GPC or Citicoline): Choline supplements can help prevent headaches and support acetylcholine synthesis when using Noopept.
  • Noopept + Racetams (e.g., Piracetam or Aniracetam): Combining Noopept with other racetams may amplify cognitive-enhancing effects and provide a more well-rounded nootropic experience.

When creating a Noopept stack, start with low doses of each compound and carefully monitor your response. Keep in mind that individual results may vary, and what works for one person may not work for another. Learn More: The Best Nootropic Stack For Ultimate Brain Performance

Noopept and Brain Health

Beyond its short-term cognitive-enhancing effects, Noopept may have long-term implications for brain health and neuroprotection. Animal studies suggest that Noopept could help mitigate age-related cognitive decline and protect against neurodegenerative conditions like Alzheimer’s disease.[6]

By promoting the expression of neurotrophic factors like NGF and BDNF, Noopept may support the maintenance and regeneration of neural tissue, contributing to overall brain health and resilience. However, more research is needed to fully understand the long-term effects of Noopept on human cognitive function and brain aging.

Where to Buy Noopept

When purchasing Noopept, it’s crucial to choose a reputable vendor that prioritizes quality, purity, and transparency. Look for companies that provide third-party lab testing results and have a proven track record of customer satisfaction. Some trusted online sources for Noopept include:

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Always exercise caution when purchasing nootropics online, and do your due diligence to ensure you’re getting a high-quality product from a trusted source.

Frequently Asked Questions (FAQ)

Is Noopept legal?

Noopept is legal to purchase and possess in most countries, including the United States. However, it is not approved by the FDA for medical use and is sold as a research compound or dietary supplement.

How long does it take for Noopept to work?

Noopept’s effects may be noticeable within an hour of administration, with peak effects occurring around 1-2 hours after ingestion. However, the full benefits of Noopept may develop over several weeks of consistent use.

Can Noopept be taken long-term?

While Noopept is considered safe for short-term use, more research is needed to fully understand its long-term effects. It’s generally recommended to cycle Noopept, taking breaks every few weeks to prevent tolerance and minimize potential side effects.

What are the best ways to take Noopept?

Noopept can be taken orally, sublingually, or intranasally. Oral administration via capsules or tablets is the most common method, but sublingual and intranasal routes may provide faster absorption and higher bioavailability.

Are there any drug interactions with Noopept?

Noopept may interact with certain medications, particularly those that affect the cholinergic or glutamatergic systems. If you are taking any prescription medications or have pre-existing health conditions, consult with a healthcare professional before starting Noopept.

Noopept Discussions on Reddit

Reddit has a vibrant community of nootropic enthusiasts who share their experiences, insights, and questions about Noopept. Let’s explore some notable discussions and user perspectives.

User Experiences and Reviews

Many Reddit users report positive experiences with Noopept, citing improvements in focus, memory, and overall cognitive function. However, some users also mention potential side effects and the importance of proper dosing and cycling.

Noopept has been helpful when I take about 10 to 15 mg in the morning. I cant take it every day or too often because it ends up giving me brain fog. Ill take it maybe once or twice a week at the most and not more than 15 mg per dose max for good results.

u/dgira574 in discussion ‘Has anyone experience negative effects from Noopept?’

Optimal Dosage and Cycling

Finding the right Noopept dosage and cycling schedule is crucial for maximizing benefits and minimizing side effects. Reddit users share their experiences and insights on optimal dosing strategies.

I take .08 mg/kg sublingually once or twice a day for four days. Then I take three days off. For me I notice a tolerance on day four. Feels fresh to me after three days off.

u/infrareddit-1 in discussion ‘Noopept – anyone still using this classic noot?’

Stacking Noopept with Other Nootropics

Noopept is often combined with other nootropics to create synergistic effects and target specific cognitive needs. Reddit users discuss their favorite Noopept stacks and share tips for optimizing results.

I take polygala, 4dma-78dhf, noopept, and Mucuna pruriens daily. For intense internship days and intense study sessions I also take either N-Acetyl Semax Amidate or sunifiram. And occasionally I’ll take alpha-gpc.

u/geophilo in discussion ‘Noopept – anyone still using this classic noot?’

These discussions highlight the importance of individual experimentation, careful dosing, and monitoring when using Noopept and other nootropics. Always prioritize safety and consult with a healthcare professional if you have concerns.

Noopept Quick Facts

For a quick overview of Noopept’s key characteristics, benefits, and usage guidelines, refer to the table below:

Chemical NameN-phenylacetyl-L-prolylglycine ethyl ester
Recommended Dosage10-30 mg per day
Main BenefitsImproved memory, focus, and learning abilities; potential anxiolytic and neuroprotective effects
Possible Side EffectsHeadaches, irritability, brain fog, sleep disturbances (rare)
Typical FormsPowder, capsules, sublingual tablets
Recommended Cycle4 weeks on, 1-2 weeks off
Stacking OptionsCholine sources (Alpha-GPC, Citicoline), Racetams (Piracetam, Aniracetam)

Keep in mind that these are general guidelines, and individual experiences may vary. Always start with the lowest effective dose and adjust according to your body’s response and personal goals.


Noopept is a potent cognitive enhancer with a growing body of research supporting its potential benefits for memory, focus, and overall brain health. By understanding its mechanisms of action, proper dosage, and potential interactions with other nootropics, you can make informed decisions about incorporating Noopept into your cognitive enhancement regimen.

Remember, while Noopept and other nootropics can be powerful tools for optimizing mental performance, they should be part of a holistic approach that prioritizes healthy lifestyle practices, such as regular exercise, balanced nutrition, adequate sleep, and stress management.

As always, we encourage you to do your own research, consult with healthcare professionals, and listen to your body when experimenting with any new supplement or nootropic. The community is here to support you on your journey toward optimal cognitive performance and well-being.

Learn More: Racetams Guide

Share your experiences, insights, and questions about Noopept in the comments below. Together, we can navigate the fascinating world of nootropics and unlock our brain’s full potential.


[1] Ostrovskaya RU, Gudasheva TA, Voronina TA, Seredenin SB. The original novel nootropic and neuroprotective agent noopept. Eksp Klin Farmakol. 2002 Sep-Oct;65(5):66-72. PMID: 12596521.

[2] Ostrovskaya RU, Gudasheva TA, Zaplina AP, Vahitova JV, Salimgareeva MH, Jamidanov RS, Seredenin SB. Noopept stimulates the expression of NGF and BDNF in rat hippocampus. Bull Exp Biol Med. 2008 Sep;146(3):334-7. doi: 10.1007/s10517-008-0297-x. PMID: 19240853.

[3] Neznamov GG, Teleshova ES. Comparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin. Neurosci Behav Physiol. 2009 Mar;39(3):311-21. doi: 10.1007/s11055-009-9128-4. PMID: 19234797.

[4] Gudasheva TA, Konstantinopolsky MA, Ostrovskaya RU, Seredenin SB. Anxiolytic activity of endogenous nootropic dipeptide cycloprolylglycine in elevated plus-maze test. Bull Exp Biol Med. 2001 May;131(5):464-6. doi: 10.1023/a:1017928116025. PMID: 11550054.

[5] Jia X, Gharibyan AL, Öhman A, Liu Y, Olofsson A, Morozova-Roche LA. Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity. J Mol Biol. 2011 Dec 16;414(5):699-712. doi: 10.1016/j.jmb.2011.09.044. Epub 2011 Oct 5. PMID: 22024593.

[6] Ostrovskaya RU, Belnik AP, Storozheva ZI. Noopept efficiency in experimental alzheimer disease (cognitive deficiency caused by beta-amyloid25-35 injection into Meynert basal nuclei of rats). Bull Exp Biol Med. 2008 Jul;146(1):77-80. doi: 10.1007/s10517-008-0207-2. PMID: 19145354.

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Erik Abramowitz is a certified Nutritional Therapy Practitioner (NTP), Naturopathic Doctoral student, health coach, and father. He is the primary content creator for and the host of the Holistic Nootropics Podcast.