If you’re into nootropic supplements1R. C. B. P. Anna Maria Pugliese, Effect of the nootropic drug oxiracetam on field potentials of rat hippocampal slices1990, there’s no doubt you’ve come across the term “racetam.”
Racetams are some of the most popular nootropics available on the market today.
When taken responsibly, racetam nootropics provide an excellent way to improve your long-term memory recall, leading to long-term memory improvement in physical and mental performance while also reducing your risk for diseases like dementia or Alzheimer’s disease2V. V. B. De Reuck J, The clinical safety of high-dose piracetam–its use in the treatment of acute stroke 1991..
While their overall molecular structure differs, those in the racetam family share a similar chemical backbone. This means racetams can cross the blood-brain barrier and easily bind with neurotransmitters in the brain, including acetylcholine, dopamine, serotonin, and norepinephrine.
This makes racetams a popular choice for both nootropic newcomers and experienced brain hackers looking to sharpen their overall cognitive function.
The following article offers a primer on the different racetam nootropics available today, discusses their benefits, and tips on using them.
Read on for a mind-blowing conversation on getting the most out of racetams for your specific needs!
What Are Racetam Nootropics?
Racetam Nootropics are a series of chemically synthesized compounds such as drugs and food supplements developed particularly to boost to produce improved cognitive function3N. M. B. R. F. P. B. L. S. G. De Vreese LP, Memory training and drug therapy act differently on memory and metamemory functioning: evidence from a pilot study 1996.
They are a class of synthetic compounds that have basic similar chemical structures.
How Racetams Affect Cognitive Function Compared To Other Nootropics
There is no customarily accepted mode of action as to how racetam nootropics function in cognitive effects. However, they enhance cognition by interaction with the brain’s cholinergic system.
The cholinergic system is involved in memory enhancement, learning attention, and other higher brain functions. Although, a few Nootropic supplements like aniracetam are not purported to have a considerable influence on choline.
It seems that racetams, particularly aniracetam and Piracetam, modulate Glutamate and AMPA receptors in the brain4S. A. Gouliaev AH, Piracetam and other structurally related nootropics 1994..
In addition, reputedly, racetam nootropics modulate acetyl cholinergic systems. However, in contrast to other nootropics, racetams have multiple modes of action and are in the different racetam classes.
Complete List Of The Racetam Family
There are more than twenty derivatives of racetam, which includes;
Top 7 Popular Racetam Nootropics
It boosts cerebral blood flow; it increases cognition, especially in aged people.
The prescribed piracetam dose is 1,600 mg 3-times a day.
It modulates AMPA and NMDA receptors which enhances the effectiveness of glutamate in the brain.
It possesses anticonvulsant and neuroprotective properties and is purported to enhance neural plasticity.
It is a water-soluble racetam nootropic.5M. K. K Nakamura, Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism Eur J Pharmacol. 2001
It is sometimes considered the best racetam. This is because it promotes choline uptake and boosts activity in the hippocampus of the brain.
It’s believed to be an effective treatment for both Alzheimer’s and major depressive disorder and maybe mental disorders.
It boosts brain fluidity which enhances communication between cells.6S. M. Malykh AG, Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders 2010
The side effects are relatively mild. They include rash, drowsiness, diarrhea, insomnia, hyperactivity.
The prescribed Pramiracetam dose is close to 250 – 400 mg up to 3-times a day.[coupon couponid=’10527′ name=’Piramiracetam’] [amazin-product-box id=”10533″]
The prescribed Oxiracetam dose is close to 750- 1,500 mg a day, split into two servings.
It aids in metabolizing phospholipids and impacts neurotransmitter release7C. D. B. D. G. E. McLean A Jr, Placebo-controlled study of pramiracetam in young males with memory and cognitive problems resulting from a head injury and anoxia 1991.
When used with physostigmine, it enhances improved memory.
It is used to decrease the symptoms of Alzheimer’s disease and memory loss.
It boosts choline-acetyltransferase (ChAT) in the brain, producing more acetylcholine.
It is a fat-soluble racetam nootropic. Thus, requiring fatty acids to be ingested.
It modulates AMPA receptors and reduces the rate of receptor desensitization.
Aniracetam is cholinergic; hence, it aids the release of 200-300% more acetylcholine.
The prescribed aniracetam dose is 750 mg twice per day.
It is an effective anxiolytic.
It aids in reducing symptoms of anxiety, depression, and panic.
It potentiates athletic/ physical performance.
The prescribed Phenylpiracetam dose is close to 100 mg twice a day.
It enhances the mass-to-volume ratio of acetylcholine (Ach), NMDA, GABA, and dopamine receptors in the brain8C. P. A.-A. I. Naftalin RJ, Piracetam and TRH analogues antagonise inhibition by barbiturates, diazepammelatonini,n and galanin of human erythrocyte D-glucose transport. 2004..
It is an anticonvulsant and thus effective in the treatment of epilepsy.
It appears that nefiracetam potentiates both GABAergic and cholinergic signaling.
It lengthens the opening of calcium channels9S. M. Malykh AG, Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders 2010.
It improves neuroplasticity.
It seems to improve memory formation and recall.
The prescribed Nefiracetam dose is close to 900 mg per day.
It is one of the fat-soluble racetam nootropics.
It converts choline to acetylcholine through a process known as High-Affinity Choline Uptake. (HACU)10C. D. B. D. G. E. McLean A Jr, Placebo-controlled study of pramiracetam in young males with memory and cognitive problems resulting from a head injury and anoxia. 1991.
It is known to associate with choline transporters; however, it’s pretty hard to determine its function after the interaction.
It could function in the preservation of choline intake into neurons when impaired.
The prescribed Coluracetam dose is 20-80 mg twice per day.
Other Racetams with Emerging Data
It is a novel drug on trial that belongs to the racetam family11J. L. J. J. Zhang H, Oxiracetam Offers Neuroprotection by Reducing Amyloid β-Induced Microglial Activation and Inflammation in Alzheimer’s Disease. PUBMED, 2020..
Research on the effect of prolonged treatment using nebracetam nootropic drugs on neurotransmitters of brain regions in rats has been carried out; however, the result in humans is not currently known.
It is an investigative chemical compound that belongs to the racetam family. However, it is a nootropic substance not widely known and in use like piracetam and other leading nootropics racetam. There are not enough reliable research materials available about fasoracetam.
It is a nootropic drug classified under the racetam family. Research purports that it enhances temporary memory in rats and monkeys12W. Y. T. J. H. D. Z. R. J. X. H. X. S. J. G. J. W. Z. P. Q. L. Q. Wang D,, Oxiracetam Mediates Neuroprotection Through the Regulation of Microglia Under Hypoxia-Ischemia Neonatal Brain Injury in Mice. Mol Neurobiol PUBMED, 2021.
It was discovered that it has a short-live effect in several animal species with a half-life below 25 minutes.
It is a nootropic drug classified under the racetam family. It has been employed in the pilot-scale study of the treatment of AIDS and neuropathy.
There is not enough reliable clinical literature about dimiracetam pharmacodynamics, mode of action, and absorption.
It is a drug that is a derivative of pyrrolidone. It is a nootropic drug classified under the racetam family, having a chemical structure similar to levetiracetam.
It is considered a 100-times potent and effective anticonvulsant drug compared to levetiracetam.
It has an elimination half-life of 8hours. It is under clinical trials; as such, there are no ample reliable research materials available about the production of seletracetam13T. M. B. A. Winnicka K,, Piracetam–an old drug with novel properties? 2005.
Sunifiram is a synthetic piracetam-derived compound.
It is considered a more potent nootropic than Piracetam. It has a mode of action that is close to nefiracetam. It is classified as ampakines, but it is less researched and understudied14T. M. B. A. Winnicka K,, Piracetam–an old drug with novel properties? 2005.
Best Racetam For You
It is important to use the right racetam class for the right purpose to get the most out of using racetam nootropics.
There might not be the best racetam that gives all functions or profound effects to all needs; however, there is the best racetam for particular benefits.
Below are some recommendations for the best racetam for a need for specific purposes.
Best Racetam For Memory Formation, Enhancement and Learning – Pramiracetam
Pramiracetam’s major effect comes from high-affinity choline absorption (HACU) into the brain(hippocampus), which significantly impacts the neurotransmitter acetylcholine synthesizing and binding to the nicotinic acetylcholine receptors.
It helps develop new synapses and nerve connections, improving the overall communication between the brain hemisphere. Hence, it helps in improving memory formation without causing revolving brain fog, logical thinking enhanced, more areas of thought and reasoning16A. R. G. U. A. M. M. V. R. M. C. I. M. B. E. Mushtaq A, Biomolecular Evaluation of Lavandula stoechas L. for Nootropic Activity. PUBMED, 2021. This improves memory retention.
The dose recommendation is 400mg two to three times daily, with the optimal dose of about 1600mg in extreme cases
Best Racetam For Mental Energy and Eliminating Brain Fog – Piracetam
Piracetam acts to eliminate brain fog and increase mental energy by affecting the chemical activities of the brain in an elevating manner17R. E. J. K. C.-S. Robert G Robinson, Double-blind randomized treatment of poststroke depression using nefiracetam. J Neuropsychiatry Clin Neurosci 2008.
This is done by increasing brain perfusion and synthesizing relevant neurotransmitters faster than normal.
This helps improve the function of brain cells and aid cell repair.
The recommended oral dose is 1.2g twice daily.
Best Racetam For Overall Brain Health – Piracetam
Piracetam has an excellent effect on the brain’s health. It uses the GABA pathway, which has been shown to improve brain function and reduce dyslexic symptoms18P. C. B. E. Z. H. R. C. M. R. F. D. S. M. L. Y. M. R. Pan Z, Cognitive impairment in major depressive disorder PUBMED, 2018.
Animal studies have also shown that it makes the cell membrane more fluid. This makes cell to cell communication easier and faster.
The recommended oral dose is 1.2g twice daily.
Best Racetam For Elderly Patients To Prevent Cognitive Decline – PhenylPiracetam
Phenylpiracetam is derived from Piracetam with an additional phenyl group.
Its action in preventing cognitive decline and memory loss is enhanced by increasing blood flow to the brain.
This keeps the brain cells active and functional.
Its phenyl group allows for greater functionality with little dose compared to Piracetam.
The recommended oral dose is 200mg three times daily.
Best Racetam To Treat Depression, Anxiety, and Social Anxiety – Oxiracetam
Oxiracetam acts as a stimulant to treat depression and anxiety. Its mechanism of action is similar to Pramiracetam. It utilizes the Acetylcholine pathway, thereby stimulating brain function.
Oxiracetam also increases cerebral perfusion.
Recommended Oral dose is 800mg twice daily.
How Mixing Racetams Affect Cognitive Abilities
It’s purported that combining or mixing racetams could provide a synergistic and additive effect.
Several racetams like oxiracetam, aniracetam, and Piracetam could be beneficial, thereby improving cognitive effects. As Piracetam may plunge the brain into action, enhance memory, and remove brain fog, oxiracetam may build rational thinking. Aniracetam may aid in seeing the grand scheme giving cognitive benefits. However, excessive or inappropriate mixing could be deadly, leading to mental disorders and adverse reactions.
Stacking is simply combining two supplements(racemate nootropics) to boost the effects. Racetam stack is the result of mixing two or more racetams to give a synergistic effect.
Popular Racetam Stacks
Advanced Memory Stack
Alpha GPC-500mg, Centrophenoxine- 500mg, Vinpocetine- 15mg
Anxiety Relief Stack
Bacopa- 250mg and L-Theanine-200mg
Cognitive Enhancement Stack
Alpha GPC and CDP Choline
Basic Racetam Stack with DMAE
consist of Aniracetam and DMAE
Energy and Clarity Stack
Caffeine, vinpocetine, and Choline.
Choline and Piracetam Stack
Caffeine and L-Theanine Combo
The Aniracetam-Piracetam-Oxiracetam Stack
Piracetam and Huperzine-A
Piracetam and Pramiracetam
Racetams Vs. Smart Drugs
Smart drugs or ‘nootropics’ can be natural or chemically synthesized compounds that boost cognitive skills. They usually enhance brain performance19G. R. C. D. C. N. S. M. S. M. R. C. L. Y. M. R. Pan Z, Pharmacological Treatment of Cognitive Symptoms in Major Depressive Disorder. CNS Neurol Disord Drug Targets PUBMED, 2017..
Other not-prescribed compounds that can boost brain performance, such as caffeine and creatine, are nootropics. In addition, medical personnel could prescribe a nootropic to treat a health condition.
Examples of smart drugs include Amphetamine and dextroamphetamine (Adderall), creatine, Huperzine-A.
While Racetams is a class of synthetic nootropics, several series of chemically synthesized compounds such as drugs and food supplements developed to boost cognitive function.
Examples of nootropic racetams include; Piracetam, aniracetam, Pramiracetam, and phenylpiracetam.
Racetam nootropics have given humans the solution of being able to improve mental or cognitive activities. There are several functions performed by racetams like improved memory, mood, anxiety, focus, learning, creativity, and brain health.
There is no single racetam that can give the whole benefit, however, there are different types best for each benefit. The most effective, potent, and maybe strongest racetam is phenylpiracetam. This is mainly because it has the shortest onset of action among the other racetam nootropics.
Research is still ongoing to synthesize more racetam for use, which would aid brain metabolism, cognitive disorders.