Lithium Orotate: Benefits, Dosing, Where To Buy, And More!

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Key Information

Lithium orotate is a natural mineral:

Lithium orotate is a form of lithium that is found in milk and dairy products and is essential for health.

Lithium orotate has mood-stabilizing effects:

Lithium orotate can help treat bipolar disorder, depression, anxiety, and substance abuse by balancing brain chemistry.

Lithium orotate has neuroprotective effects:

Lithium orotate can prevent brain damage, enhance neurogenesis, and reduce the risk of dementia and neurodegenerative diseases.

Lithium orotate has minimal side effects:

Lithium orotate can be taken in small doses without causing toxicity, weight gain, or kidney problems.

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Lithium Orotate: The Trace Mineral Supplement for Mood, Memory and More

In the realm of holistic cognitive enhancement, there’s a growing interest in the potential of lithium orotate as a natural supplement for supporting mental health and brain function. As a trace mineral found in varying amounts in food and water, lithium has a long history of use in psychiatry at high doses for bipolar disorder. However, recent research suggests that low-dose lithium supplementation, particularly in the form of lithium orotate, may offer a range of benefits for mood, memory, and overall brain health.

At Holistic Nootropics, our mission is to provide evidence-based, nutrition-first cognitive enhancement strategies that recognize the intricate connection between mind and body. By demystifying the world of nootropics through expert insights, scientific research, and practical applications, we aim to empower you with the knowledge and tools to optimize your mental well-being and cognitive performance.

In this comprehensive guide, we’ll explore the potential benefits of lithium orotate, its mechanisms of action in the brain, recommended dosages, and safety considerations. We’ll also delve into the latest research and real-world experiences shared by individuals in online communities like Reddit. Whether you’re new to nootropics or a seasoned enthusiast, this article will provide valuable insights to help you make informed decisions about incorporating lithium orotate into your holistic brain health regimen.

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What is Lithium Orotate?

Lithium orotate is a supplemental form of lithium, consisting of lithium bound to orotic acid. This combination is believed to enhance lithium’s bioavailability and delivery to the brain compared to other forms like lithium carbonate, which is typically prescribed at much higher doses for bipolar disorder.

While lithium has been used in psychiatry since the late 1940s, interest in low-dose lithium supplementation has grown in recent years as researchers explore its potential neuroprotective and cognitive-enhancing properties. Lithium orotate, in particular, has gained popularity among those seeking a natural way to support mood, mental clarity, and brain health.

How Lithium Orotate Works in the Brain

Lithium orotate is thought to influence brain function through several key mechanisms:

  • Inhibition of GSK-3B enzyme: Lithium has been shown to inhibit glycogen synthase kinase-3 beta (GSK-3B), an enzyme involved in various cellular processes. This inhibition leads to increased levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophin-3, which support the growth, survival, and plasticity of neurons[1].
  • Reducing glutamate toxicity: Lithium may help protect neurons from the damaging effects of excessive glutamate, an excitatory neurotransmitter, by modulating NMDA receptors[2].
  • Increasing neuroprotective proteins: Studies suggest that lithium upregulates the expression of bcl-2, a protein that promotes neuronal survival and resilience[3].

These mechanisms contribute to lithium’s potential neuroprotective and neurotrophic effects, which may underlie its benefits for mood, cognition, and brain health.

Potential Benefits of Lithium Orotate Supplementation

Mood Support

One of the most well-known potential benefits of lithium orotate is its ability to support a balanced mood and emotional well-being. Many users report experiencing a calming effect and reduced anxiety when taking low-dose lithium supplements[4]. Lithium may also help alleviate symptoms of depression, as suggested by a study showing that microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer’s disease[5].

Learn More: Best Natural Mood Enhancing Supplements and Biohacks


Lithium has demonstrated neuroprotective properties in various studies, suggesting its potential to slow the progression of neurodegenerative diseases like Alzheimer’s and Parkinson’s[6][7]. By protecting neurons against oxidative stress, inflammation, and the accumulation of toxic proteins like beta-amyloid, lithium may help preserve brain structure and function over time.

Memory and Cognitive Enhancement

Research indicates that lithium supplementation may support memory and overall cognitive function. A study found that long-term lithium treatment was associated with increased hippocampal volume and improved memory performance in patients with bipolar disorder[8]. Additionally, lithium has been shown to increase levels of N-acetyl-aspartate (NAA), a marker of neuronal health and function, which correlates with higher IQ scores[9].

Learn More: The Best BDNF Supplements, Foods, And Lifestyle Hacks

Lithium Orotate Dosage and Safety

Lithium orotate supplements typically contain between 1-10mg of elemental lithium, which is significantly lower than the therapeutic doses of lithium carbonate prescribed for bipolar disorder (300-1200mg). At these low doses, lithium orotate is generally considered safe and well-tolerated, with minimal side effects[10].

However, it’s essential to be aware of potential drug interactions, particularly with medications that affect serotonin levels, such as SSRIs and MAOIs. As with any supplement, it’s always best to consult with a healthcare professional before starting lithium orotate, especially if you have pre-existing medical conditions or are taking other medications.

Many users find benefits from cycling lithium orotate, taking it for a few weeks or months at a time, followed by a break. This approach may help prevent tolerance and maintain the supplement’s effectiveness over the long term.

Lithium Orotate vs Other Forms of Lithium

FormTypical DoseBioavailabilityProsCons
Lithium Orotate1-10mg elemental LiHighCrosses BBB easily, fewer side effectsLimited research
Lithium Carbonate300-1200mg (113-226mg elemental Li)LowerMost researched for bipolarMore side effects, requires monitoring
Lithium Citrate300-1200mgModeratePrescribed for bipolarSome side effects
Lithium Aspartate1-10mg elemental LiModerateBioavailableLimited research

FAQ about Lithium Orotate

  • Is lithium orotate safe? At recommended doses (1-10mg elemental lithium), lithium orotate is generally considered safe with minimal side effects. However, it’s essential to consult with a healthcare professional before starting any new supplement.
  • What is the recommended lithium orotate dosage? Most lithium orotate supplements contain 5mg of elemental lithium. It’s generally recommended to start with the lowest effective dose and adjust based on individual response and tolerance.
  • Can lithium orotate be taken with SSRIs or other medications? Lithium may interact with certain medications, particularly those that affect serotonin levels. Always consult with a healthcare professional before combining lithium orotate with other medications.
  • Are there any side effects of lithium orotate? At low doses, side effects of lithium orotate are typically mild and may include mild gastrointestinal discomfort, headache, or slight tremor. If you experience any concerning side effects, discontinue use and consult with a healthcare professional.
  • How long does it take for lithium orotate to work? Individual response to lithium orotate may vary. Some users report feeling the effects within a few days, while others may need several weeks of consistent use to notice benefits.

Where to Buy Lithium Orotate

When purchasing lithium orotate supplements, it’s essential to choose a reputable brand that adheres to strict quality control standards. Look for supplements that are third-party tested for purity and potency, and free from contaminants and fillers.

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Lithium orotate supplements are typically available in capsule or tablet form, with doses ranging from 1-10mg of elemental lithium per serving. Prices may vary depending on the brand and serving size, but expect to pay around $15-30 for a one to two-month supply.

Lithium Orotate Discussions on Reddit

Reddit communities like r/Nootropics and r/StackAdvice offer valuable insights into real-world experiences with lithium orotate supplementation. Let’s explore some notable topics and user perspectives.

Dosage and Cycling

I take it for anxiety, not sure how much it has done for the anxiety but i am very calm and evenleveled. Also have a headache.. i take 1,25 in the morning and in the night.

u/Searchforanswers90 in discussion ‘Just ordered some lithium orotate, are there any things I should be concerned about?’

Many Reddit users report positive experiences with low-dose lithium orotate, typically in the range of 1-10mg per day. Some individuals find benefit from splitting their dose between morning and evening, while others prefer taking it all at once. Cycling lithium orotate, with breaks every few weeks or months, is a common approach to maintain its effectiveness and minimize potential side effects.

Mood and Cognitive Benefits

I think its helped me think a little more clearly. I take 5mg personally. Pretty sure it worked because I was probably deficient, a major natural source is our drinking water, and I drink bottled or filtered water, so wasnt getting any from my water.

u/Icy_Raisin6471 in discussion ‘Anyone try lithium orotate?’

Users frequently report improvements in mood stability, mental clarity, and overall cognitive function when supplementing with lithium orotate. Some individuals attribute these benefits to correcting a potential lithium deficiency, as modern diets and filtered water may contain lower levels of this trace mineral compared to ancestral environments.

Interactions and Side Effects

Mixing with psychedelics can pose a serious seizure risk and a trip to the er.

u/joemushrumski in discussion ‘Just ordered some lithium orotate, are there any things I should be concerned about?’

While lithium orotate is generally well-tolerated at low doses, it’s crucial to be aware of potential interactions with other substances, particularly medications that affect serotonin levels and psychedelics. Some users report mild side effects like headaches or gastrointestinal discomfort, which may resolve with time or dose adjustment. As with any supplement, it’s essential to monitor your individual response and consult with a healthcare professional if you experience any concerning side effects.


Lithium orotate is a promising supplement for supporting mood, memory, and overall brain health. By providing low-dose lithium in a bioavailable form, lithium orotate may offer neuroprotective and cognitive-enhancing benefits without the more significant side effects associated with high-dose lithium pharmaceuticals.

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