Pyrroloquinoline Quinone PQQ: Benefits, Dosing, Where To Buy, And More!

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Key Information

PQQ is a mitochondrial booster:

PQQ enhances mitochondrial function and biogenesis, which increases cellular energy and health.

PQQ is a powerful antioxidant:

PQQ scavenges free radicals and protects cells from oxidative damage and aging.

PQQ has cognitive benefits:

PQQ improves memory, cognition, attention, and neurogenesis, and prevents neurodegeneration.

PQQ has physical benefits:

PQQ supports liver, kidney, heart, and gut health, and boosts metabolism and immunity.

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Unleash Your Brain’s Full Potential with Pyrroloquinoline Quinone (PQQ)

In today’s fast-paced world, where mental clarity and cognitive performance are paramount, we are constantly seeking ways to optimize our brain function. Enter Pyrroloquinoline Quinone (PQQ), a remarkable compound that has garnered significant attention in the realm of nootropics and brain health. This blog post will delve into the intricacies of PQQ, shedding light on its mechanisms, benefits, and the scientific evidence supporting its efficacy.

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What is Pyrroloquinoline Quinone (PQQ)?

Pyrroloquinoline Quinone, commonly referred to as PQQ, is a naturally occurring compound with a unique quinone structure. It was initially discovered in bacteria and later found in various plant sources, including kiwifruit, green peppers, and parsley. Despite its ubiquity in nature, the human body does not produce PQQ on its own, making dietary supplementation a necessity to harness its potential benefits.

Classification and Discovery

PQQ was initially classified as a vitamin, but further research revealed its distinct role as a cofactor – a molecule that assists enzymatic reactions within the body. Its discovery dates back to 1964, when Norwegian biochemist Jens Hauge first identified it as a novel prosthetic group in bacterial glucose dehydrogenase enzymes. Subsequent studies unveiled its presence in interstellar dust particles, adding to its mystique and potential cosmic origins.

Mechanisms of Action

To fully appreciate the impact of PQQ on cognitive function, it is essential to understand its mechanisms of action within the body. PQQ exerts its effects through three primary pathways:

1. Mitochondrial Biogenesis

PQQ has a remarkable ability to stimulate the production of new mitochondria, the powerhouses of our cells responsible for energy generation. By increasing mitochondrial density, PQQ enhances cellular energy levels, which translates into improved cognitive performance and overall brain function. Learn More: Mitochondrial Biogenesis Supplements

2. Antioxidant Properties

PQQ exhibits potent antioxidant activity, protecting brain cells from oxidative stress and inflammation. Its ability to neutralize free radicals and reduce inflammatory markers contributes to the maintenance of a healthy neurological environment, essential for optimal cognitive function.

3. Neuroprotection and Neurogenesis

PQQ plays a crucial role in supporting nerve growth factor (NGF) production, a protein that promotes the growth, maintenance, and survival of neurons. By stimulating NGF, PQQ fosters neuronal regeneration and protects against age-related cognitive decline and neurodegenerative disorders.

Benefits of PQQ

The multifaceted mechanisms of PQQ translate into a diverse array of benefits for cognitive function and overall brain health:

  • Enhanced Memory and Learning: By increasing mitochondrial energy production and supporting neuronal growth, PQQ has been shown to improve memory formation, recall, and learning abilities.
  • Improved Focus and Concentration: The energy-boosting effects of PQQ contribute to heightened focus and sustained concentration, making it an invaluable ally for students, professionals, and anyone seeking to enhance their mental performance.
  • Neuroprotective Properties: PQQ’s antioxidant and anti-inflammatory properties offer protection against neurological disorders, such as Alzheimer’s disease, Parkinson’s disease, and stroke. By reducing oxidative stress and supporting neuronal health, PQQ may play a role in preventing or slowing the progression of these conditions.
  • Mood and Sleep Regulation: PQQ has been linked to improved mood and better sleep quality, potentially due to its ability to modulate neurotransmitter levels and reduce oxidative stress, which can contribute to mood disorders and sleep disturbances.
  • Longevity and Anti-Aging: By supporting mitochondrial function and reducing oxidative stress, PQQ may have implications for longevity and healthy aging. Its potential role in slowing the aging process and preventing age-related cognitive decline has garnered significant scientific interest.

Pyrroloquinoline Quinone (PQQ) FAQ

1. Is PQQ safe to consume?

PQQ is generally considered safe for human consumption when taken in recommended dosages. However, it is essential to consult with a healthcare professional before incorporating any new supplement into your regimen, especially if you have underlying health conditions or are taking medications.

2. What is the recommended dosage of PQQ?

While there is no officially established dosage for PQQ, most studies have used dosages ranging from 10 mg to 20 mg per day. It is advisable to start with a lower dose and gradually increase it as needed, under the guidance of a healthcare professional.

3. Are there any side effects associated with PQQ supplementation?

PQQ is generally well-tolerated, and serious side effects are rare. However, some individuals may experience mild side effects, such as headaches or insomnia, particularly at higher doses. It is crucial to follow the recommended dosages and consult a healthcare professional if you experience any adverse reactions.

4. Can PQQ interact with medications?

While there are no known major interactions between PQQ and medications, it is always advisable to consult with your healthcare provider before taking PQQ, especially if you are on any prescription or over-the-counter medications.

5. Is PQQ better combined with other supplements?

PQQ has been shown to work synergistically with other supplements, such as CoQ10, to enhance its effects on cognitive function and mitochondrial health. However, it is important to consult with a healthcare professional before combining supplements to ensure safety and efficacy.

Where to Buy Pyrroloquinoline Quinone (PQQ)

PQQ supplements are widely available from various online retailers and health food stores. However, it is crucial to purchase PQQ from reputable sources to ensure quality and purity. Look for supplements that contain the patented and natural BioPQQ™ form of PQQ, which is produced through bacterial fermentation and is considered the highest quality form available.

Here are some recommended sources to consider when purchasing PQQ supplements:

  1. Life Extension PQQ Caps: Life Extension offers high-quality PQQ supplements in capsule form, containing 20 mg of BioPQQ™ per serving.
  2. Doctor’s Best PQQ: Doctor’s Best is a reputable brand that offers PQQ supplements in various dosages, all containing the patented BioPQQ™ form.
  3. Pure Nootropics PQQ: Pure Nootropics is a trusted source for high-quality nootropic supplements, including PQQ in capsule or powder form.

Remember to always follow the recommended dosages and consult with a healthcare professional before incorporating PQQ or any other supplement into your regimen.

Pyrroloquinoline Quinone (PQQ) Discussions on Reddit

To gain insights into the real-world experiences and perspectives of PQQ users, we delved into various Reddit discussions, uncovering a wealth of information and user testimonials.

Improved Sleep Quality and Reduced Fatigue

One of the most commonly reported benefits of PQQ on Reddit is its positive impact on sleep quality and overall energy levels. Several users have shared their experiences of experiencing better sleep and reduced fatigue after incorporating PQQ into their daily routines.

PQQ has improved my sleep quality significantly

u/sprintswithscissors in discussion ‘PQQ has improved my sleep quality significantly’

This sentiment is echoed by several other users, who report experiencing reduced fatigue and increased energy levels throughout the day after incorporating PQQ into their daily routine.

Synergistic Effects with CoQ10

Another common theme that emerges from Reddit discussions is the potential synergistic effects of combining PQQ with CoQ10. Many users report enhanced cognitive benefits when taking these two supplements together, potentially due to their complementary roles in supporting mitochondrial function and energy production.

PQQ goes for as little as $0.17 for a 20mg daily serving. The paper hasn’t been published yet so it’ll be interesting to see the actual effect sizes (amounts of improvements) they found.

u/creamyhorror in discussion ‘[PQQ] (2021, RCT) Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study’

This discussion highlights the potential cognitive benefits of PQQ, particularly when combined with CoQ10, and the anticipation of further research findings to shed light on the specific effect sizes and improvements observed.

Dosage and Safety Considerations

While many users report positive experiences with PQQ, there are also discussions around appropriate dosages and potential side effects. Some users have reported experiencing headaches or insomnia at higher doses, emphasizing the importance of starting with lower dosages and gradually increasing as needed.

If you are really into anti-aging, learn from Dr. Peter Attia.

u/sacca7 in discussion ‘Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects (2013)’

This comment emphasizes the importance of consulting reputable sources and healthcare professionals when considering PQQ supplementation, particularly in the context of anti-aging and longevity.

Individual Variability and Lack of Noticeable Effects

It is important to acknowledge that some Reddit users have reported not experiencing any noticeable effects from taking PQQ. This highlights the potential individual variability in response to supplements and the need for personalized approaches.

Ive never felt any effects from it whatsoever, and Im usually hyper aware of the effects and side effects from supplements.

u/T30000 in discussion ‘Thoughts on PQQ (PYRROLOQUINOLINE QUINONE)’

While some users may not experience immediate or noticeable effects, it is essential to approach PQQ supplementation with realistic expectations and to consult with healthcare professionals for personalized guidance.

Scientific Evidence and Research Findings

To provide a comprehensive understanding of PQQ and its potential benefits, it is crucial to examine the scientific evidence and research findings supporting its efficacy. While the majority of studies have been conducted on animals, there are several human trials that shed light on the effects of PQQ on cognitive function and overall brain health.

Study Findings
Nakano et al. (2015) In a double-blind, placebo-controlled trial involving 65 adults aged 50-70 with forgetfulness, supplementation with 20 mg of PQQ and 100 mg of CoQ10 for 24 weeks resulted in significant improvements in immediate memory, spatial awareness, and other cognitive functions. The effects were enhanced when PQQ was combined with CoQ10.
Itoh et al. (2016) A randomized, double-blind, placebo-controlled study on 41 healthy middle-aged and elderly adults found that supplementation with 21.5 mg of PQQ for 12 weeks led to significant improvements in memory, executive function, complex attention, cognitive flexibility, and reaction time compared to the placebo group.
Harris et al. (2013) In a study involving 10 human subjects, supplementation with PQQ resulted in significant decreases in plasma C-reactive protein (an inflammatory marker), interleukin-6 (IL-6), and urinary trimethylamine N-oxide levels, along with changes in urinary metabolites consistent with enhanced mitochondrial-related functions.

These studies, along with various animal and in vitro experiments, provide compelling evidence for the potential cognitive-enhancing and neuroprotective properties of PQQ. However, it is important to note that more extensive human trials are needed to further validate these findings and establish optimal dosages and long-term safety profiles.

[Rucker R., Chowanadisai W., Nakano M. Potential physiological importance of pyrroloquinoline quinone. _Alternative Medicine Revue_. 2009 Sep;14(3):268-77. URL]

[Nakano M., Kawasaki Y., Suzuki N., Takara Y. PQQ was found to improve not only immediate memory, but also other higher brain functions such as spatial awareness. The effects of PQQ were enhanced when the substance was used with CoQ10. _Journal of Nutritional Science and Vitaminology_ 61, 233-240, 2015

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Erik Abramowitz is a certified Nutritional Therapy Practitioner (NTP), Naturopathic Doctoral student, health coach, and father. He is the primary content creator for and the host of the Holistic Nootropics Podcast.

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