Fl Modafinil: Benefits, Dosing, Where To Buy, And More!

Hey there!

Welcome to my review of Flmodafinil.

As someone way too deep down the nootropic rabbit hole, I wondered if there was a way to get my hands on Modafinil without a prescription and soon stumbled across its “over-the-counter” analog, Flmodafinil.

I spent over 20 hours researching Flmodafinil and talking to experts to put this review together to help you decide whether this compound is suitable for you.

The following article discusses everything you need to know about Flmodafinil including what it is, its benefits, side effects, other user reviews, and most importantly where to buy it (because it’s kind of hard to find)>

So if you’re ready to learn more about one of the most potent cognitive enhancers on the planet, let’s jump into it!

Where To Buy Fl Modafinil

More Bioavailable Modafinil

Fl Modafinil

4.7

Shop NowSave 15% w. code “holisticnootropics”

Modafinil analog
More bioavailable than modafinil with less addictive properties
Promotes wakefulness and mental alertness
Shown to boost memory and learning capabilities
Available without a prescription

What Is Fl Modafinil

Fl Modafinil or spelled Flmodafinil, also known as CRL 40,940 flmodafinil, bisfluoromodafinil, or lauflumide, is a modafinil analog, meaning it shares many of the latter’s qualities, such as its therapeutic use, its much-appreciated use as a nootropic, and its additional benefit of the compound being of low rates of dependency. ¹

Modafinil is a medication used to treat narcolepsy and other sleep disorders.

It is commonly used as a nootropic due to its effect on alertness, focus, memory, cognition, and learning.²³

In studies, modafinil has shown to improve episodic and working memory.⁴

It also has shown to improve cognitive function and even learning by activating several areas in the brain that promotes cognition and learning.⁵

Unlike other prescription smart drugs utilizing amphetamines, modafinil has fewer side effects and a decreased risk of addiction.⁶

Effects such as dependence, or addiction colloquially, are deterrents for using amphetamines as a central nervous system stimulant (CNS stimulant) treatment option.

With this in mind, the chemical modafinil has been undergoing clinical trials as a smart drug since it is suggested to improve cognitive function without the problem of addiction.⁷

The same can be said for fl modafinil, as mounting scientific research suggests fl modafinil as a potent wakefulness-promoting agent.⁸

Fl Modafinil vs Modafinil

Compound Structure

Flmodafinil or CRL 40,940 is a bisfluoro- analogue of Modafinil.

This means that unlike Modafinil, flmodafinil has two fluoride parts that connect to the parent compound modafinil.⁹

Bioavilability

Chemistry aside, this means that CRL 40,940 has higher bioavailability than modafinil, which is one positive point.

Both modafinil and CRL 40,940 are poorly soluble in water but are quickly absorbed by the body when taken orally, especially in powder form, but CRL 40,940 is more quickly acting.¹⁰

Half-life

In terms of half-life or how long the two medications stay in the body, flmodafinil has a similar or even longer half-life than the parent drug modafinil, with modafinil having a half-life of 12-15 hours.¹¹

dosage

Of the two, flmodafinil is more potent if you base it per mass.

The standard flmodafinil dose is considerably less if you compare it with modafinil, with flmodafinil dosage requiring a low dose.¹²

side effects

The side effects of modafinil are headache, nausea, and decreased appetite, anxiety, insomnia, dizziness, diarrhea, and rhinitis.¹³

It may be expected that flmodafinil may have a similar profile on side effects.

safety

Of the two, modafinil is the more researched drug compared to flmodafinil.

Modafinil is already on the market as an FDA-approved prescription drug used to treat narcolepsy and other sleep-related disorders.

Given that it is FDA-approved, modafinil has an already-guaranteed level of safety.

Flmodafinil, on the other hand, is a research chemical and is currently being used in clinical studies to test its safety.¹⁴¹⁵

Fl Modafinil vs Fl Adrafinil

compound structure

Both flmodafinil and fladrafinil share the same parent chain and have the same and therapeutic uses.

Flmodafinil is the fluoridated analogue of modafinil whereas fladrafinil is the fluoridated analogue of adrafinil.

Flmodafinil and fladrafinil have the same configuration having two fluoride units attached to the main compound.

Again, it is important to stress that flmodafinil and fladrafinil share the same parent chain of modafinil and adrafinil.

bioavailability and half-life

This allows for greater bioavailability compared to the parent drug modafinil.¹⁶

As for half-life, both drugs have the same half life but both may have varying differences in terms of bioavailability depending on the time of day.¹⁷¹⁸

This particular nuance may have an effect or a benefit when these compounds are used in a particular time of day.

side effects

Fl adrafinil may have a similar profile of side effects with its nonfluorinated parent adrafinil including malodorous urine, headache, disturbed sleep, anxiety, and feeling unpleasantly stimulated.¹⁹

Fl modafinil, on the other hand, may show similar side effects to modafinil such as headache, nausea, and decreased appetite, anxiety, insomnia, dizziness, diarrhea, and rhinitis.²⁰

safety

Both drugs require more research studies that have more research subjects to test for safety especially in the early phases of trial.

Animal studies must first be done to conduct safety studies with the promotion of further studies should the safety in animal testing is satisfactory.

How Fl Modafinil Works In The Brain

Flmodafinil, like modafinil, is a dopamine reuptake inhibitor.

From the name of its drug class, CRL 40,940 acts by preventing dopamine reuptake back into the presynaptic neuron.²¹

This allows for more time and frequency of dopamine to bind to the receptors D1 and D2.²²²³

Effects of Flmodafinil on Dopamine

Flmodafinil inhibits dopamine reuptake at the presynaptic neuron, allowing for the increased dopamine binding to the receptor.

In preliminary studies, it is noteworthy that flmodafinil’s selectivity in its dopamine reuptake inhibition gives it an advantage over other similar nootropics.²⁴

This particular selectivity of inhibition allows for a lower but more stable level of dopamine in all the neurons enough to produce feelings of wakefulness but removes the unwanted side effects such as dependence and rebound hypersomnia.

An additional effect of flmodafinil on dopamine is that it promotes improved wake response and arousal with the continued, sustained action of dopamine on the receptors.²⁵

In trials, this is the same premise that allows flmodafinil to have applications in many neurological disorders, from sleep-related disorders to attention-deficit disorders and to even neurological disorders resulting from dopamine dysfunction such as Parkinson’s disease.²⁶²⁷

Role of Dopamine in Wakefulness

Dopamine plays a role in wakefulness but its role is complex.²⁸

When binding to D1 and D2 receptors, Dopamine produces wakefulness and increased arousal.

Specifically, dopamine promotes wakefulness by decreasing NREM sleep.

Another critical effect of dopamine is that it causes decreased wakefulness at low levels, whereas, with high levels, it causes increased wakefulness.²⁹

But another notion would be how long and frequently dopamine is released to bind to the receptors that produce these effects.

As demonstrated clinically, the continued release of high dopamine levels into the synaptic space to bind to the dopamine receptors can cause rebound hypersomnolence.

Rebound hypersomnolence is a common side-effect of earlier wake-promoting agents such as amphetamines which cause high dopamine levels to bind to the D1 and D2 receptors.³⁰³¹

Effects of Flmodafinil on Memory and Cognition

As a nootropic or a CNS stimulant, it is hypothesized that flmodafinil might just be the same as modafinil in terms of having the benefit of improved memory and cognition with fewer side effects of sleep debt from rebound hypersomnia.³²³³

Currently, studies are being undertaken to demonstrate the effects of flmodafinil and its derivatives in several areas of memory and cognition.

The parameters being tested and measured are neural responses from learning behaviors, memory, attention, response time, and reaction time.³⁴³⁵

Flmodafinil Benefits

Like modafinil, flmodafinil has the same cognitive benefits but with the added benefit of better bioavailability.

Here are some of the potential benefits of flmodafinil.

Wakefulness-promoting agent

Similar to modafinil, flmodafinil induces and maintains wake to avoid daytime sleepiness.

In the study of healthy research subjects, this chemical carries feelings of alertness with no repercussion of feeling sleepy.³⁶

One of the potential benefits of flmodafinil is that it improves the capacity to carry out all your day’s taks. ³⁷ ³⁸

Cognitive Enhancement

One of the benefits that is currently under clinical trials is the cognitive enhancement by flmodafinil.

In studies on research subjects, flmodafinil, like modafinil, can be used as a smart drug with better bioavailability.

Studies show that the drug improves memory and reduces working memory errors.³⁹⁴⁰

Mood Enhancer

With the premise that flmodafinil is a structural analog of modafinil, flmodafinil can be used as a mood booster.

Flmodafinil specifically treats the manifestation of residual tiredness and fatigue to induce wakefulness, which translates into a better mood and overall contentment.⁴¹

Stress, Mood and Sleep Disorders

Stress

Stress from work and even stress in general may be necessary to move forward.

But there are cases wherein too much stress can cause grossly slow body movements and even poor response to stimuli.

Flmodafinil, with the same expected action as modafinil, can improve the body’s gross movement in response to stress, mainly due to its effects on locomotion from the adrenergic receptors.⁴²

Mood

Mood disorders ranging from major depressive disorder to bipolar disorders have been known to affect human function especially in that of society.

It can affect a person’s productivity and can also affect social interaction.

Studies were done on modafinil to combat mood disorders namely depression.

In these studies, modafinil improved mood disorder scores especially in the depression scores.⁴³⁴⁴

With flmodafinil, this benefit on mood may also be evident in clinical trials.

Sleep Disorders

With the constant demands of work, people may develop sleep disorders due to sleep deprivation.

For much of the working class, especially those who may work during the day or at night, the random working hours may result in shift work sleep disorder.⁴⁵

In this disorder, insomnia develops, which can cause daytime sleepiness due to sleep debt.

The sleep-deprived workers can pose a risk for those around them or occupational risk.

These can result in injury and even death if left unchecked.⁴⁶

In some, mood disorders such as anxiety and depression can also cause sleep problems, which can result in the vicious cycle of sleep debt.⁴⁷

In this regard, modafinil and even flmodafinil improve wakefulness and can be used to treat sleep disorders.

Modafinil is a known stimulant which treats many sleep disorders.

Given that flmodafinil has a similar

Clinical Trials/Evidence

Wake Promotion

In a recent study, Flmodafinil is suggested to be a new potent wake-promoting compound.

The study aimed to explore the wake-promoting effects of flmodafinil.

In lab tests, flmodafinil appears to have improved drug-induced wakefulness compared with the placebo, and has improved REM and NREM sleep by affecting specific sleep waves.

Further when comparing with modafinil, the results on wakefulness and recovery sleep are comparable and both have not caused rebound hypersomnia.⁴⁸

Cognitive Enhancer

In a meta-analysis, research was done on the different cognitive enhancers.

As highlighted, flmodafinil is the bisfluoro analog of modafinil that has the same action of modafinil as a treatment for daytime sleepiness.

It can also treat other sleep-related disorders other than narcolepsies such as idiopathic hypersomnia, night-shift sleep disorder, obstructive sleep disorder, obstructive sleep apnea, multiple sclerosis, Parkinson’s disease, and myotonic dystrophy, depression, schizophrenia, attention-deficit disorder, and cocaine dependence and withdrawal.⁴⁹

Other Clinical trials

Currently, flmodafinil is undergoing clinical trials for the claimed therapeutic uses in the treatment of attention-deficit/hyperactivity disorder or ADHD, narcolepsy, and idiopathic hypersomnia, among others.

Furthermore, as the drug is heavily related to modafinil, flmodafinil appears to have been hypothesized to treat hypnagogic or hypnopompic hallucinations, sleep paralyses or autonomic acts as part of sleep disorders.⁵⁰

To confirm if flmodafinil can also be a smart drug like modafinil, a recent clinical trial is underway with 60 healthy subjects.

These healthy subjects undergo treatment and are tested for cognitive function with tests for neural processing during the interference processing and neural processing during feedback based learning for the primary outcome, which are the more specific parameters for cognition.

Other outcome measures considered in the study are response time, accuracy, and reaction time.⁵¹

Is Fl Modafinil A Weak Dopamine reuptake inhibitor?

Flmodafinil is not a potent dopamine reuptake inhibitor, but this does not mean that it is not practical.

This action is what gives flmodafinil its cognitive benefits due to the moderate to high levels of dopamine that bind to the dopamine receptors.⁵²⁵³

Even at a low dose, unlike modafinil, flmodafinil can exert its action at its minimum allowed value.

Optimum dopamine levels promote wakefulness and other benefits such as memory, cognition, and even mood. ⁵⁴⁵⁵

Its higher bioavailability also compensates for it being a weak reuptake inhibitor of dopamine as more molecules of it are present in the bloodstream unlike modafinil.⁵⁶

Flmodafinil, though a weak inhibitor, exerts far more action on the neurons, causing potent behavioral effects, including learning and cognition, than other substances with greater affinity for reuptake inhibition.⁵⁷

Is Flmodafinil Legal?

Modafinil, its parent compound, has the status of a Schedule 4 Drug by the FDA so a prescription is required before it can be dispensed.

No restrictions on procurement were imposed on the other analogs of modafinil, including flmodafinil.

Currently, flmodafinil is used as a patented research chemical, so it is intended for research use.

Having been used as a research chemical, CRL 40,940 currently has no license or has undergone any safety trials.

Regarding legality, CRL 40,940 is currently used on research subjects in clinical trials.

However, you can purchase flmodafinil as a flmodafinil powder or liquid flmodafinil online with the caveat that some vendors may sell it for research purposes and not for direct human consumption.⁵⁸⁵⁹⁶⁰

How Much Does Fl Modafinil Cost?

Currently, the 1500mg (50mg/ml) liquid flmodafinil costs $69.99 per bottle and the 5g powdered flmodafinil costs $180.00.

Flmodafinil tinctures are also available at $30.00 for 30ml.

Flmodafinil tablets cost at around $22.00 to $36.00 depending on the dosage strength.

However, it should be noted that due to the changes in the supply and demand for flmodafinil, there may be changes in the pricing as it may scale up or down.

Recommended Dose

Currently, while clinical studies are underway, the effective and safe dose range of flmodafinil is from 25mg to 100mg.

Just 25mg of flmodafinil is enough to have that much-wanted nootropic effect.

Doses of up to 100mg may be considered safe according to several flmodafinil reviews.

Again, it should be noted that clinical studies are still underway to determine the safe dose and that mindfulness of what to dose to take is highly advised.

Standard Modafinil Dose

The standard modafinil dose, as opposed to flmodafinil, is twice that of flmodafinil at 100mg to 200mg.

In studies, the dose of modafinil is best at 200mg to 400mg, with 400mg divided into two doses per day.

It was reported that in doses of 200mg twice a day, wakefulness significantly improved during the day.⁶¹

Fl Modafinil Half-Life

Half-life is defined as the time it takes for a concentration of a substance to decrease to half the concentration.

Modafinil has a half-life of 12-15 hours.

With this in mind and that flmodafinil is an analogue of modafinil, it is said that flmodafinil may have a similar half-life to that of modafinil.

But there are claims that flmodafinil may have a longer half life than that of modafinil. ⁶²

This is one advantage that flmodafinil has over modafinil one of the analogues.

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