Exploring natural cognitive enhancers often brings us to ancient medicinal traditions, where plants like Celastrus paniculatus, also known as the intellect tree or Jyotishmati, have been used for centuries to support mental health and performance.
At Holistic Nootropics, we’re dedicated to providing evidence-based information on natural supplements to help you optimize cognitive function and overall well-being. In this guide, we’ll explore the history, benefits, and science behind Celastrus paniculatus, helping you decide if this herb fits your holistic nootropic regimen.
As a certified functional nutritional therapy practitioner, my interest in Celastrus paniculatus began with its traditional use for enhancing mental clarity. Understanding its benefits and science has deepened my appreciation for this remarkable plant, and I’m excited to share its potential with you.
What is Celastrus paniculatus?
Celastrus paniculatus is a woody climbing shrub native to India and parts of Southeast Asia. It has been used in Ayurvedic medicine for centuries to treat various neurological disorders and cognitive issues. The seeds and oil of this plant are of particular interest, as they contain a variety of active compounds believed to be responsible for its nootropic effects.
The plant is known by several common names, including:
- Black oil plant
- Intellect tree
- Jyotishmati
- Malkangni
As interest in natural cognitive enhancers grows, Celastrus paniculatus has emerged as a promising option for those seeking to boost their memory, learning, and overall brain function.
Learn More: What are Nootropics? The Ultimate Beginners Guide To Cognitive Enhancers
Celastrus Paniculatus Extract Capsules | 500mg by Nootropics Depot
Boost cognitive abilities with Celastrus Paniculatus.
Traditional Uses and History
Celastrus paniculatus has a long history of use in Ayurvedic medicine, where it is known as “Jyotishmati,” or the “light of intellect.” It has been used to treat a wide range of neurological and cognitive issues, including:
- Memory loss
- Cognitive dysfunction
- Paralysis
- Epilepsy
- Insomnia
In addition to its nootropic properties, Celastrus paniculatus has also been used to treat rheumatism, arthritis, sciatica, and leprosy in traditional Ayurvedic practice.
Active Compounds and Mechanisms of Action
The seeds of Celastrus paniculatus contain a variety of active compounds, including:
- Sesquiterpenes: celastrine, celapanine, celapagin, paniculatin
- Alkaloids
- Flavonoids
- Terpenoids
These compounds are believed to contribute to the nootropic effects of Celastrus paniculatus through several mechanisms, including:
Acetylcholinesterase inhibition: Some compounds in Celastrus paniculatus, such as the sesquiterpenes, may inhibit the enzyme acetylcholinesterase, which breaks down the neurotransmitter acetylcholine. By preventing the breakdown of acetylcholine, Celastrus paniculatus may enhance memory, learning, and overall cognitive function. Learn More: The Brain-Boosting Effects Of Choline
Antioxidant properties: Celastrus paniculatus has been shown to possess antioxidant properties, which may help protect brain cells from oxidative stress and damage. This neuroprotective effect could contribute to its cognitive-enhancing benefits.
Potential Nootropic Benefits
Based on traditional use and preliminary scientific research, Celastrus paniculatus may offer several nootropic benefits, including:
- Memory enhancement: By increasing acetylcholine levels in the brain, Celastrus paniculatus may help improve memory formation, retention, and recall.
- Improved learning and recall: The cognitive-enhancing effects of Celastrus paniculatus may facilitate faster learning and better recall of information.
- Neuroprotection: The antioxidant properties of Celastrus paniculatus may help protect brain cells from oxidative stress and damage, potentially slowing cognitive decline and supporting long-term brain health.
- Reduced mental fatigue and stress: Some users report that Celastrus paniculatus helps reduce mental fatigue and improve stress resilience, allowing for better cognitive performance under pressure.
- Mood elevation: Although more research is needed, some anecdotal evidence suggests that Celastrus paniculatus may have mood-enhancing effects, potentially supporting mental well-being and motivation. Learn More: Best Nootropics For Motivation
Scientific Research
While human studies on Celastrus paniculatus are limited, several animal studies have investigated its effects on cognitive function, memory, and learning. These studies provide preliminary evidence for the nootropic potential of this herb.
Memory and Learning Studies
| Study | Model | Dosage | Results |
|---|---|---|---|
| Bhanumathy et al. 2010[1] | Rats & mice | 350-1050 mg/kg in rats, 500-1500 mg/kg in mice | Improved memory, reduced AChE activity |
| Kumar and Gupta 2002[2] | Rats | 100-200 mg/kg | Enhanced cognition, antioxidant effects |
| Gattu et al. 1997[3] | Rats | 50-200 mg/kg | Reversed scopolamine-induced memory deficits |
These studies suggest that Celastrus paniculatus may have memory-enhancing and neuroprotective effects, potentially mediated by its ability to modulate acetylcholine levels and reduce oxidative stress in the brain. However, it’s important to note that more human research is needed to confirm these benefits and determine optimal dosing.
Dosage and Administration
Celastrus paniculatus is available in various forms, including seeds, oil, and standardized extracts in capsules or tablets. The optimal dosage may vary depending on the form and individual needs.
Traditional Ayurvedic dosing often involves starting with a low dose of seeds, such as 5-10 seeds per day, and gradually increasing the dose as tolerated. Some practitioners recommend chewing the seeds thoroughly to release the active compounds.
Capsules or tablets containing standardized extracts of Celastrus paniculatus typically provide 200-500 mg per serving. As with any new supplement, it’s best to start with the lowest effective dose and increase gradually if needed.
When using Celastrus paniculatus, consider the following tips:
- Start with a low dose and increase gradually
- Take with food to enhance absorption and reduce the risk of gastrointestinal discomfort
- Use for at least 4-6 weeks to assess effects, as some benefits may take time to develop
- Consider cycling the supplement, taking breaks every few months to maintain sensitivity and prevent tolerance
Potential Side Effects and Interactions
Celastrus paniculatus is generally well-tolerated, with few reported side effects in traditional use or clinical studies. However, some potential side effects may include:
- Gastrointestinal discomfort
- Headache
- Dizziness
- Insomnia (if taken too close to bedtime)
One rat study suggested that Celastrus paniculatus seed extract may impair sperm development, but more research is needed to confirm this effect and determine its relevance to human use.
As Celastrus paniculatus may affect acetylcholine levels in the brain, it’s important to exercise caution when combining it with other cholinergic substances, such as:
- Acetylcholinesterase inhibitors (e.g., donepezil, rivastigmine)
- Cholinergic nootropics (e.g., Alpha-GPC, citicoline)
- Some mushrooms (e.g., lion’s mane, Hericium erinaceus)
If you are taking any medications or have a pre-existing medical condition, consult your healthcare provider before starting Celastrus paniculatus or any new supplement.
FAQ about Celastrus paniculatus
Where to Buy Celastrus paniculatus
When purchasing Celastrus paniculatus, it’s essential to choose a reputable supplier that provides high-quality, pure, and standardized extracts. Look for products that have been third-party tested for purity and potency, and avoid suppliers that make exaggerated or unsubstantiated claims.
Celastrus Paniculatus Extract Capsules | 500mg by Nootropics Depot
Some factors to consider when choosing a Celastrus paniculatus supplement include:
- Extraction method and solvent used
- Standardization of active compounds
- Presence of additives or fillers
- Reputation and transparency of the manufacturer
- Third-party testing and certification (e.g., GMP, USP, NSF)
At Holistic Nootropics, we are dedicated to providing our readers with the most up-to-date and reliable information on natural cognitive enhancers. While we do not endorse specific brands or products, we encourage you to do your own research and consult with your healthcare provider to find the best Celastrus paniculatus supplement for your needs.
Celastrus paniculatus Discussions on Reddit
The nootropic community on Reddit has been discussing Celastrus paniculatus, sharing personal experiences, dosing recommendations, and potential interactions. Let’s take a look at some of the most relevant discussions.
User Experiences and Reviews
I can see why they call celastrus ‘intellect tree’. Mind you this is not some limitless brain boost, but it’s there and to me worth it.
This user’s experience highlights the subtle yet noticeable effects of Celastrus paniculatus. It’s important to note that while many users report positive effects, the benefits may not be as dramatic as some marketing claims suggest.
Yep, easily one of my favorite nootropics. Affordable and effective on a lot of people. It almost feels like weed at high enough dosages, but instead of making you giggly and dazed, it actually lets you focus, like a really intense l-theanine of sorts.
This user’s comparison to L-theanine is interesting, as both compounds are known for their potential focus-enhancing effects. However, it’s crucial to approach high doses with caution and to start with lower doses to assess individual tolerance and response.
Dosing Recommendations
I believe the oil is 5 to 15 drops a day, usually 1 drop = 1ml, oral. Check with the manufacturer of your oil if it is edible, because India makes massage oils out of many things.
This user provides a general guideline for dosing Celastrus paniculatus oil. However, it’s important to note that dosage can vary depending on the concentration of the oil and individual factors. Always start with the lowest effective dose and increase gradually as needed.
Stacking and Interactions
Celastrus Paniculatus naturally raises acetylcholine which in turn fixes dopamine levels (PMID: 20645820). Nicotine does the same thing via acetylcholine receptors but as a big hit and big rise in dopamine which is cause for addiction, something you won’t have from celastrus paniculatus.
This user highlights the potential mechanism of action of Celastrus paniculatus, comparing it to nicotine but noting its potentially lower risk of addiction. This information underscores the importance of understanding how different nootropics interact with neurotransmitter systems in the brain.
While these Reddit discussions provide valuable insights from personal experiences, it’s crucial to approach them with a critical mindset. Individual responses to nootropics can vary greatly, and what works for one person may not work for another. Always conduct thorough research and consult with a healthcare professional before incorporating any new supplement into your regimen.
Conclusion
Celastrus paniculatus, the “intellect tree,” offers intriguing potential as a natural nootropic supplement. With its long history of use in Ayurvedic medicine and promising preliminary research, it may provide benefits for memory, learning, and overall cognitive function. However, as with any supplement, it’s essential to approach its use with caution and informed decision-making.
At Holistic Nootropics, we believe in a comprehensive approach to cognitive enhancement that goes beyond supplementation. While Celastrus paniculatus may be a valuable addition to your nootropic regimen, it’s important to consider it as part of a broader strategy that includes proper nutrition, regular exercise, stress management, and quality sleep.
As research on Celastrus paniculatus continues to evolve, we remain committed to providing you with the most up-to-date and evidence-based information. Remember to consult with your healthcare provider before starting any new supplement, especially if you have pre-existing medical conditions or are taking medications.
We encourage you to share your experiences with Celastrus paniculatus in the comments below. Your insights can help other readers make informed decisions and contribute to our community’s collective knowledge. As always, stay curious, stay informed, and prioritize your cognitive health on your journey to optimal mental performance.
Learn More: Best Nootropics For Motivation
References
[1] Bhanumathy M, Harish MS, Shivaprasad HN, Sushma G. Nootropic activity of Celastrus paniculatus seed. Pharm Biol. 2010 Mar;48(3):324-7. doi: 10.3109/13880200903127391. https://pubmed.ncbi.nlm.nih.gov/20645820/
[2] Kumar MH, Gupta YK. Antioxidant property of Celastrus paniculatus Willd.: a possible mechanism in enhancing cognition. Phytomedicine. 2002 May;9(4):302-11. doi: 10.1078/0944-7113-00136. https://pubmed.ncbi.nlm.nih.gov/12120811/
[3] Gattu M, Boss KL, Terry AV Jr, Buccafusco JJ. Reversal of scopolamine-induced deficits in navigational memory performance by the seed oil of Celastrus paniculatus. Pharmacol Biochem Behav. 1997 Aug;57(4):793-9. doi: 10.1016/s0091-3057(96)00391-7. https://pubmed.ncbi.nlm.nih.gov/9259008/
Is Celastrus Paniculatus or Malkangani Oil available?
where are the refs you superscript in this article?
Hi Jeff, if you click on the number you will see the reference with the link. Thanks for dropping by!