Alpha-GPC (L alpha glycerylphosphorylcholine) is a natural choline compound found in the brain and body, known to improve cognitive function and memory.
It is used endogenously to make acetylcholine, a neurotransmitter essential for cognitive function.
This powerful nootropic, sometimes also referred to as Choline alphoscerate, has been shown to improve mental and physical performance, especially regarding memory, focus, and attention span.
It can also help protect the brain from age-related damage and improve brain cell communication which is crucial for nerve growth factor production.
What are Best Alpha GPC Supplements in September 2023 – Quick Answers
There are many different Alpha GPC supplements available in the market today.
Choosing the right one can be difficult, especially if you don’t know what to look for. This article will discuss the seven best Alpha GPC supplements currently available.
Alpha GPC – Frequently Asked Questions
What is Alpha-GPC?
Alpha-GPC is a choline-containing compound that is naturally found in the body. It is also found in certain foods, such as eggs and fish. Alpha-GPC supplements are typically made from soy lecithin or rice flour.
How does Alpha-GPC work?
Alpha-GPC is thought to work by increasing the levels of acetylcholine in the brain. Acetylcholine is a neurotransmitter that is involved in memory, learning, and muscle control. By increasing the levels of acetylcholine in the brain, Alpha-GPC may improve cognitive function and help to prevent age-related cognitive decline.
What are the benefits of Alpha-GPC?
Alpha-GPC is thought to offer a variety of benefits, including improved cognitive function, increased muscle mass, and reduced body fat. Additionally, Alpha-GPC may also help to protect the brain from damage caused by Alzheimer’s disease and other age-related disorders.
Is Alpha-GPC safe?
Alpha-GPC is generally considered to be safe for most people. However, it is important to speak with a healthcare provider before taking any supplement, especially if you have a medical condition or are taking medication.
What is Alpha GPC
Alpha glyceryl phosphorylcholine is a natural compound found in the brain, and it is also a parasympathomimetic acetylcholine precursor.
Mechanism of action
L alpha glyceryl phosphorylcholine has the ability to rapidly deliver choline molecules to the brain across the blood-brain barrier.
Safe dose of alpha-GPC supplementation
The estimated human dose of α-GPC, which is considered safe by US-FDA, is up to 196.2 mg/person/day.
However, it is highly recommended to seek professional medical advice before consuming any supplements because of insufficient evidence in the medical literature.
Your health care professional may advise you to take lower doses or higher doses of α-GPC depending on your individual medical history and comorbidities.1United States Food and Drug Administration, Generally Recognized as Safe (GRAS) Determination for the Use of AlphaSize® Alpha-Glycerylphosphoryl Choline (PDF) 25 January 2012
How α-GPC helps improve cognitive function
The administration of α-GPC leads to an increase in the release of the neurotransmitter acetylcholine.
This neurochemical reaction helps to:2Enea Traini, Vincenzo Bramanti, and Francesco Amenta, Choline Alphoscerate (Alpha-Glyceryl-Phosphoryl-Choline) An Old Choline- containing Phospholipid with a Still Interesting Profile As Cognition Enhancing Agent Current Alzheimer Research. 2013
- Enhance memory and learning functions
- Prevent cognitive impairment
- Prevent brain fog
- Slow age-related cognitive decline
- Lead to overall cognitive improvement
Why α-GPC is important to the brain
Alpha-GPC increases choline, which means it has two primary functions in the brain:
- It serves as a precursor for acetylcholine, a neurotransmitter involved in memory formation and consolidation
- It is a membrane constituent – choline molecules are used to construct the fatty acid found in the plasma membranes of neurons
Choline is an essential nutrient for our body and the richest sources of dietary choline are eggs, beef, fish, pork, and chicken.
Choline molecules have a significant positive impact on neurotransmitter production and cell membrane composition.
The Benefits Of Supplementing With Alpha GPC
Alpha-GPC and Neuroprotection
As a common nootropic and choline prodrug, α-GPC offers several neuroprotective benefits, especially the ability to protect brain cells from destructive neurotoxins.
α-GPC also helps prevent stroke and transient ischemic attack by regulating blood flow in the body.3GIUSEPPE BARBAGALLO SANGIORGI,MARIO BARBAGALLO,MARCELLO GIORDANO,MARIA MELI,RITA PANZARASA, α-Glycerophosphocholine in the Mental Recovery of Cerebral Ischemic Attacks NYAS PUBS. 1994
A study found that α-GPC can provide neuroprotection against seizure-induced neuronal death and cognitive impairment by increasing hippocampal neurogenesis.4Song Hee Lee , Bo Young Choi , Jin Hee Kim, A Ra Kho, Min Sohn, Hong Ki Song , Hui Chul Choi , Sang Won Suh, Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment Brain Res. 2017
Experimental rat studies found that α-GPC treatment can protect against the functional and morphological cellular damage evoked by focal brain irradiation.5Imola Plangár , Emília Rita Szabó, Tünde Tőkés, Imola Mán, Kitti Brinyiczki, Gábor Fekete, István Németh, Miklós Ghyczy, Mihály Boros, Katalin Hideghéty, Radio-neuroprotective effect of L-alpha-glycerylphosphorylcholine (GPC) in an experimental rat model J Neurooncol. 2014
Alpha-GPC and Cognitive Decline
A study found that α-GPC can effectively protect against age-associated cognitive decline by improving cognitive function through reduced neuronal death and BBB disruption.6Song Hee Lee , Bo Young Choi , Jin Hee Kim, A Ra Kho, Min Sohn, Hong Ki Song , Hui Chul Choi , Sang Won Suh, Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment Brain Res. 2017/mfn]
Alzheimer’s Disease and Dementia
Alzheimer’s diseaseAlzheimer’s disease is the most common neurodegenerative disorder characterized by memory loss, impaired cognition, behavior problems, and other signs of deterioration.
Since l alpha glycerylphosphorylcholine increases the levels of the neurotransmitter acetylcholine, it thus helps to improve memory function among individuals suffering from mild to moderate Alzheimer’s disease.6Alzheimer’s Drug Discovery Foundation Alpha-GPC Alzheimer’s Drug Discovery Foundation. 2020
Alzheimer’s patients who received the alpha-GPC treatment reported less decline in all cognitive, functional, and behavioral measures.7Francesco Amenta , Anna Carotenuto , Angiola Maria Fasanaro , Raffaele Rea, Enea Traini , The ASCOMALVA (Association between the Cholinesterase Inhibitor Donepezil and the Cholinergic Precursor Choline Alphoscerate in Alzheimer’s Disease) Trial: interim results after two years of treatment J Alzheimers Dis. 2014
Dementia is an impairment in cognitive functioning – thinking, remembering, and reasoning – to the extent that it interferes with a person’s daily activities.
α-GPC helps to improve the memory and cognitive functioning of individuals suffering from a decline in mental performance associated with dementia.
An open-label study found that after three months of treatment with α-GPC, patients’ memory function improved substantially.8S I Gavrilova , I V Kolykhalov , E V Ponomareva , Ya B Fedorova , N D Selezneva, [Clinical efficacy and safety of choline alfoscerate in Zh Nevrol Psikhiatr Im S S Korsakova. 2018
Several medically peer-reviewed studies, human studies, and animal experiments suggest that taking alpha-GPC can restore acetylcholine levels, improve cognition, and have positive benefits on the nervous system of dementia patients.9C M Lopez , S Govoni, F Battaini, S Bergamaschi, A Longoni, C Giaroni, M Trabucchi, Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine Pharmacol Biochem Behav. 199110Maria De Jesus Moreno Moreno , Cognitive improvement in mild to moderate Alzheimer’s dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial Clin Ther. 200311Sheila A Doggrell, Suzanne Evans, Treatment of dementia with neurotransmission modulation Expert Opinion on Investigational Drugs . 2005
Alpha-GPC and Memory Loss
α-GPC is known for its positive impact on improving memory and learning speed which is especially helpful for individuals facing memory issues and cognitive decline due to old age.
It does this by substantially improving synaptic signaling and functional recovery by supporting neuronal reorganization processes in the brain.12Adam G Parker, Allyn Byars, Martin Purpura, and Ralf Jäger, The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility J Int Soc Sports Nutr. 2015
Alpha-GPC and Mood Enhancement
A clinical study found that the improvements in apathy and affective disorders were greater among patients taking alpha GPC.13L Parnetti, G Abate, L Bartorelli, D Cucinotta, M Cuzzupoli, M Maggioni, C Villardita, U Senin, Multicentre study of l-alpha-glyceryl-phosphorylcholine vs ST200 among patients with probable senile dementia of Alzheimer’s type Drugs Aging. Mar-Apr 1993
α-GPC not only boosts the production of acetylcholine and increases the release of dopamine, calcium, and cell membrane phospholipids which translates into mood enhancement for many folks.
Alpha-GPC and Athletic Performance
The ergogenic properties and beneficial effects of Alpha-GPC are well known in sports nutrition, especially among athletes and those simply looking to add physical endurance to their exercise program.
According to a study published in the journal Mechanisms of Ageing and Development, α-GPC has been shown to enhance power output and improve overall athletic performance, prevent exercise-induced depletion of choline levels, increase endurance, promote muscular function, and replenish energy levels.14Lena Marcus, Jason Soileau, Lawrence W. Judge, and David Bellar, Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance J Int Soc Sports Nutr. 201715Francesco Amenta, Seyed Khosrow Tayebati, Daniela Vitali, Maria Antonietta Di Tullio, Association with the cholinergic precursor choline alphoscerate and the cholinesterase inhibitor rivastigmine: an approach for enhancing cholinergic neurotransmission Mech Ageing Dev. 2006
Alpha-GPC supplementation can also improve reaction time and lead to significantly higher accuracy scores during tasks.16Lena Marcus, Jason Soileau, Lawrence W. Judge, and David Bellar, Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance J Int Soc Sports Nutr. 2017
Alpha-GPC and Growth Hormone Release
Alpha-GPC improves the secretion of growth hormone, which is an anabolic hormone that helps in longitudinal bone growth and building muscle mass.
Choline alphoscerate has been shown to increase growth hormone levels, especially in young adults by stimulating growth hormone secretion in the pituitary gland.17Takashi Kawamura, Takeshi Okubo, Koji Sato, Satoshi Fujita, Kazushige Goto, Takafumi Hamaoka, Motoyuki Iemitsu, Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults Nutrition. 2012
Its effects on growth hormone production can also positively impact cell growth, cell regeneration, and tissue development processes.
Alpha-GPC vs. Other kinds of Choline
Alpha-GPC vs. CDP Choline (Citicoline)
Citicoline is a choline-containing nootropic compound with cognitive-enhancing properties similar to α-GPC.
Both Citicoline and alpha glycerophosphocholine are converted to choline. However, the differentiating factor is that CDP choline has a cytidine molecule while α-GPC has a glycerol molecule.18Vincenzo Parisi, Francesco Oddone, Lucia Ziccardi, Gloria Roberti, Gianluca Coppola, and Gianluca Manni, Citicoline and Retinal Ganglion Cells: Effects on Morphology and Function Curr Neuropharmacol. 2018
This means α-GPC can be more effective than CDP choline when seeking to:19G Gatti 1, N Barzaghi, G Acuto, G Abbiati, T Fossati, E Perucca, A comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citicoline in normal volunteers Int J Clin Pharmacol Ther Toxicol. 1992
- Improve cognition,
- Slow age-related cognitive decline,
- Increase physical endurance,
- Stimulate growth hormone production,
- And enhance power output in physically strenuous tasks
According to the International Journal of Clinical Pharmacology, α-GPC also has vasorelaxant action similar to acetylcholine. Hence, it may help hypertensive patients to achieve low blood pressure by dilating blood vessels.20G Gatti 1, N Barzaghi, G Acuto, G Abbiati, T Fossati, E Perucca, A comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citicoline in normal volunteers Int J Clin Pharmacol Ther Toxicol. 1992
Alpha-GPC vs. Choline Bitartrate
A few experimental rat studies suggest that although α-GPC is more bioavailable than choline bitartrate, both may produce similar health benefits.
In terms of the side effects, scientific evidence shows that α-GPC has a lower tendency to cause gastrointestinal issues due to its increased bioavailability.
However, since bitartrate is a synthetic formulation, it is, therefore, a relatively inexpensive way to boost choline in the brain.
Alpha-GPC vs. Phosphatidylcholine
Both α-GPC and phosphatidylcholine have the ability to cross the blood-brain barrier and have similar effects on the central nervous system. However, they differ in their molecular weight and structure.
The molecular weight of phosphatidylcholine is 753 units, while the molecular weight of α-GPC is only 256 units. Therefore, when compared to phosphatidylcholine, α-GPC has the ability to readily permeate cellular membranes, including the blood-brain barrier due to its lower molecular weight.
7 Best Alpha-GPC Supplements – September 2023
Below is my shortlist of the Top 7 Best Alpha-GPC Nootropic Supplements available today:
Improves oxygenation, nutrient absorption and stimulate neurotransmitter production for better cognitive function
Stimulates the production of neurotransmitters
Supports increases in concentration, learning, short-term memory, and problem-solving
Reduce age-related cognitive decline while improving overall mental performance
- Preformulated for easy access to essential nootropics
- Best value for nootropic cognitive enhancement
- All-natural ingredients with no fillers/preservatives
- Includes B-vitamins for enhanced metabolism
- Some ingredients may be underdosed for specific nootropic therapy
NooCube is a brain-boosting supplement that contains a special blend of ingredients designed to help increase mental performance, focus, and clarity. While all the ingredients are important, Alpha-GPC stands out as one of the most important. Alpha-GPC (also known as alpha-glycerylphosphorylcholine) is a natural form of choline, an essential nutrient for cognitive function and healthy nerve cells.
This nutrient helps maintain proper communication between neurons in the brain and supports memory formation and recall.
Alpha-GPC is also helpful for improving concentration and focus by providing more acetylcholine to the brain, which aids in better decision making and faster problem solving. Through its ability to support overall cognitive performance, Alpha-GPC can help improve mental clarity and alertness while also reducing feelings of anxiety and stress.
Noocube contains a generous dose of Alpha-GPC (150mg per serving) backed up by other clinically proven nootropic ingredients such as Lutemax 2020, Bacopa Monnieri, Huperzia Serrata extract, Pterostilbene, Resveratrol, L-theanine, L-tyrosine, Oat Straw extract and Cat’s Claw extract.
Vitamin B1, B7 & B12 were added to ensure optimal absorption of all nutrients contained in NooCube; this combination helps enhance brain activity while providing long lasting energy with no crash or jitters associated with caffeine or stimulants like Adderall.
The recommended dose for NooCube is two capsules per day taken on an empty stomach with water approximately 45 minutes before breakfast or lunch; this will allow you to experience the full effects of this powerful nootropic supplement while keeping your mind sharp throughout the day. Taking two capsules daily can have noticeable effects from day one but it is always best to take it consistently over longer period (3 – 4 weeks) to experience maximum results.
With so many potential benefits packed into one supplement it’s easy to see why NooCube has become such a popular choice amongst those looking for an all natural way to improve their cognitive performance.
Not only does it contain some high quality active ingredients but its inclusion of Alpha GPC makes it an ideal source for those seeking this specific nutrient without having to take additional supplements or modify their diets in order to do so. Therefore I would highly recommend NooCube as an excellent source of Alpha GPC that can help you unlock your mental potential.
Alpha Brain delivers a blend of potent nootropics that promote alpha brain waves and improved cognitive function
The formula includes L-Theanine, phosphatidylserine, L-tyrosine, cats claw, be it in a propriety form
There are no artificial additives, flavors, sweeteners, colors, caffeine, dairy or gluten in the product
Keto and paleo diet friendly
Alpha GPC is one of the keystone ingredients of Alpha Brain, a dietary supplement that helps support both short-term and long-term cognitive functions, such as mental clarity, cognitive speed, and enhanced focus.
It is the flagship nootropic product offered by Onnit, a company that has earned a rock-solid reputation in the fitness industry for offering premium health products emphasizing functional health and elite athletic performance.
Alpha Brain is the preferred nootropic product of some of the biggest names in sports media like Joe Rogan.
This blend includes other potent nootropics like L- Theanine, phosphatidylserine, L-tyrosine, and cats claw, which deliver boosts in dopamine while reducing stress and promoting alpha brain waves.
There is also leucine and Pterostilbene for enhanced fat and protein synthesis to promote peak physical performance.
Alpha Brain does not contain artificial additives, flavors, sweeteners, colors, caffeine, dairy, gluten, or nuts. Hence, it is also keto and paleo diet-friendly.
A pack of 90 capsules of 100mg each is available for 79.95 USD.
Mind Lab Pro
Designed to optimize cognitive functions through 11 natural ingredients that work in 6 bio-pathways
Boosts serotonin levels which can help improve your mood, sleep quality, appetite control, stress management,
Mind Lab Pro helps improve focus, memory, clarity, energy levels without relying on stimulants or artificial additives
Contains premium forms of each ingredient for enhanced potency and activity, while avoiding potential side effects associated with lower quality ingredients
Mind Lab Pro aims to provide an all-in-one solution for improving mental health & performance without any harsh side effects like those associated with prescription medications or other supplements on the market today.
It contains 11 clinically studied ingredients that work synergistically to improve focus, memory, clarity, and energy levels. For example, Rhodiola Rosea helps reduce fatigue, while Citicoline creates Alpha-GPC, an important neurotransmitter for alertness and concentration. Phosphatidylserine helps protect neurons from damage, while L-Theanine helps reduce stress and anxiety.
In addition to these ingredients, Mind Lab Pro also contains Lion’s Mane Mushroom, which has been shown to stimulate Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). These proteins are important for developing new neurons in the brain and releasing neurotransmitters such as dopamine, which can help improve mood and focus.
Mind Lab Pro has been developed to affect the following six key bio-pathways:
- Neuro-Energy Metabolism
- Antioxidant Enhancements
- Neurotransmitter Support
- Neural Structures Protection
- Stress/Anxiety Resistance
- Brain Circulation/Oxygenation
The recommended dosage is two capsules daily in the morning or early afternoon. You can safely increase your dose to four capsules daily during increased cognitive demand. Taking Mind Lab Pro with water, juice, or coffee is best.
I’ve been using Mind Lab Pro for several extended periods of high-demand brain activity, and I can confidently say that it lives up to its claims.
If you are looking for a natural supplement to help boost your cognitive performance, then Mind Lab Pro is an excellent choice to get the most out of your day and start building toward long-term cognitive performance.
Doublewood is a US-based manufacturer that provides one of the best alpha gpc supplements with a 100% money-back guarantee.
This supplement is derived from non-GMO soy lecithin, and it does not contain any artificial color, flavoring, or preservatives. It is also dairy-free, gluten-free, and sugar-free.
Doublewood tests its product for purity and potency to prevent any side effects if taken as directed.
Doublewood’s alpha-gpc increases memory and learning speed, improves mental clarity, prevents brain fog, and enhances cognition. This exclusive formulation not only improves brain health but also helps to maintain physical energy levels while performing strenuous tasks.
As of this writing, verified customers have the product rated 4.8/5.0 on their website.
A pack of 60 capsules of 300mg each will only cost you 19.95 USD.
Pure Nootropics Alpha-GPC
Pure Nootropics was established by a group of health and fitness enthusiasts who became passionate about the idea of advancing the mental and physical health of society at large.
Alpha-GPC by Pure Nootropics is made in the USA without using magnesium stearate and then subsequently packed into veggie capsules free from gluten, gelatin, dairy, and preservatives. Hence, it is also compatible with kosher and vegan-friendly diets.
It is available in two formulations – capsule and powder. Both formulations do not leave any aftertaste, and the powder formulation can be easily dissolved in water for consumption.
This alpha-GPC product uses a superior quality choline source, and it delivers choline right where your brain needs it for cognitive fuel. It also keeps your choline levels stable throughout the day without causing any choline spikes or crashes and keeps you productive without affecting the quality of your sleep.
Each capsule contains 250mg of α-GPC per serving, and a pack of 60 capsules will cost you $21.99 USD.
Cosmic Nootropics Alpha-GPC
Cereton Alpha-GPC helps improve cognitive function and memory
Formulated with 100% alpha-GPC from nootropic-grade ingredients
Aids in the relief of symptoms associated with Alzheimer’s disease, psycho-organic syndrome, and more
No artificial additives, flavorings, or chemical preservatives
Cosmic Nootropics belongs to the parent company, Sotex Pharm Firm, which is located in Moscow, Russia.
Cosmic Nootropics manufactures Cereton Alpha-GPC which contains 40.5% of metabolically protected choline and has a dose-dependent effect on the levels of acetylcholine in the brain.
This supplement is formulated using 100% alpha-GPC sourced from nootropics-grade raw materials in a GMP facility to ensure quality and safety. It contains no artificial additives, flavorings, or chemical preservatives. It has been proven to alleviate the symptoms of Alzheimer’s disease, psycho-organic syndrome, various types of dementia, and cognitive disorders including disorientation, low self-esteem, lack of motivation, and concentration difficulties.
As per the most common label doses, it is recommended to take 1 capsule of Cureton, thrice daily and preferably after meals to avail maximum health benefits. However, please consult your doctor or medical professional for appropriate guidance on dosing which may be best suited for you.
One pack of Cureton will cost you 46USD, and it contains 28 pills, each containing 400 mg of α-GPC.
Nootropics Depot Alpha-GPC
Nootropics Depot offers a high-quality alpha-GPC product available in both capsule and powder formulations. It is manufactured in the USA and does not contain dairy, gluten, yeast, or artificial additives.
This product is backed by ample research to support its use as a nootropic and effective daily supplement for improving memory, enhancing learning speed, and improving mental clarity.
The alpha-GPC found in this supplement is derived from soy lecithin, and it does not contain GMOs. It is also lab-tested and verified for product purity, potency and identity so that you don’t have to worry about inaccurate labeling, presence of contaminants, or use of any unapproved drugs.
The powder formulation can easily be dissolved with water or any other beverage. The capsule formulation contains 150mg of α-GPC in each capsule which can be taken once or twice a day after meals as advised by your health care professional.
As of May 2022, a pack of 60 capsules will cost you somewhere between $16 USD to $35 USD.
Now α-GPC 300mg supplement contains 300 mg of α-GPC in every serving, and it is manufactured in the USA.
This supplement comes with a disclaimer that the US FDA has not approved it.
This product helps to improve memory, learn faster, and enhance focus. It also has the ability to improve memory formation and retention while enhancing brain cell communication and nerve growth factor production.
The α-GPC found in this supplement helps boost your mental energy levels which keeps you productive throughout the day without affecting your sleep pattern.
It is available in an easy-to-swallow gelatin capsule, and it does not contain GMOs, artificial additives, preservatives, or flavors.
One capsule provides 300 mg of α-GPC per serving which can be taken once daily after meals or as suggested by your medical professional. It costs about 40 USD for one pack of 60 capsules.
That’s it for our list of the best Alpha GPC supplements. We hope you found this information helpful and that it helps you choose the right product for your needs. Leave us a comment below and let us know what you think or if you have any questions about alpha-GPC or any of the products on our list.