ACP-105 is gaining recognition as a promising compound for both cognitive enhancement and muscle growth. As a selective androgen receptor modulator (SARM), it’s catching attention for its potential benefits.
At Holistic Nootropics, with my expertise as a certified functional nutritional therapy practitioner (FNTP), we focus on providing evidence-based, holistic strategies to optimize mental health and cognitive performance. In this guide, we’ll dive into how ACP-105 works, its benefits, safety considerations, and practical applications.
Learn More: What are Nootropics? The Ultimate Beginners Guide To Cognitive Enhancers
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How ACP-105 Works
ACP-105 functions as a partial agonist of androgen receptors, selectively binding to these receptors in skeletal muscle and brain tissue.[1][2] This selective binding allows ACP-105 to exert its effects on specific target tissues while minimizing unwanted side effects associated with non-selective androgen receptor activation.
In the brain, ACP-105 has been shown to increase androgen receptors in the hippocampus, a region crucial for memory formation and cognitive function.[3] By modulating androgen signaling in this area, ACP-105 may enhance cognitive performance, particularly in domains such as memory, concentration, and alertness.
When it comes to muscle growth, ACP-105 works by reducing high-density lipoproteins and increasing lean muscle mass without causing muscle wasting.[1][3] This selective anabolic effect allows for targeted muscle growth and strength gains while minimizing the risk of adverse effects on other tissues.
ACP-105 by Science.bio
Science.bio’s ACP-105 promotes nerve growth factor to aid in brain cell regeneration and cognitive recovery.
Benefits of ACP-105
The unique mechanism of action of ACP-105 translates into a range of potential benefits for both cognitive enhancement and physical performance. Let’s explore some of the key advantages of this promising SARM:
- Cognitive Enhancement: By increasing androgen receptors in the hippocampus, ACP-105 may improve memory, concentration, and alertness.[3] This cognitive boost can be particularly beneficial for individuals seeking to optimize their mental performance, whether for academic pursuits, professional demands, or personal growth.
- Muscle Growth and Fat Loss: ACP-105 has been shown to increase strength and endurance while reducing abdominal and visceral fat.[4] For athletes, bodybuilders, and fitness enthusiasts, these effects can support the pursuit of a lean, muscular physique and enhance overall physical performance.
- Potential Therapeutic Uses: Beyond its nootropic and performance-enhancing properties, ACP-105 may have therapeutic potential in various contexts. It has been investigated for the treatment of age-related cognitive decline, muscle wasting conditions like sarcopenia and cachexia, and bone degenerative disorders such as osteoporosis.[1][2][3]
- Low Risk of Side Effects: Compared to anabolic steroids, ACP-105 offers a more favorable safety profile. It is non-aromatizing, meaning it does not convert to estrogen and avoids estrogenic side effects.[2] Additionally, ACP-105 has not been shown to cause liver or prostate damage, making it a potentially safer alternative for those seeking performance enhancement.[1]
Dosage and Cycling
When it comes to using ACP-105, proper dosage and cycling protocols are essential for maximizing benefits while minimizing risks. The recommended dosage of ACP-105 is 1mg/kg body weight per day.[2] For men, this typically translates to 10-20mg per day, while women may opt for a lower dosage of 5-10mg per day.
Cycle length is another important consideration. A typical ACP-105 cycle lasts 8-14 weeks, allowing sufficient time for the compound to exert its effects while avoiding potential long-term risks. It’s crucial to incorporate post-cycle therapy (PCT) after an ACP-105 cycle to prevent testosterone suppression and maintain hormonal balance.[1][4]
Learn More: Get in the Zone: Best Nootropics for ADHD & Focus
ACP-105 Stacks
While ACP-105 can be used on its own, some individuals may choose to stack it with other compounds to target specific goals. Here are a few popular ACP-105 stacks:
- Cutting Stack: Combining ACP-105 with Cardarine and Stenabolic can create a powerful cutting stack aimed at maximizing fat loss while preserving lean muscle mass.
- Bulking Stack: Pairing ACP-105 with LGD-4033 and MK-677 can support rapid muscle growth and strength gains during a bulking phase.
- Cognitive Enhancement Stack: Stacking ACP-105 with Noopept and Citicoline may synergistically enhance cognitive function, promoting better memory, focus, and mental clarity.
Learn More: Best Nootropics For Studying, Memory, and Focus
Safety and Side Effects
While ACP-105 is generally well-tolerated, it’s important to be aware of potential side effects, particularly at higher doses. Some individuals may experience headaches, fatigue, or exhaustion due to testosterone suppression.[4] It’s worth noting that ACP-105 is a research chemical and has not been approved by the FDA for human use. Pregnant and nursing women, as well as children, should avoid using ACP-105.
ACP-105 vs Other SARMs
To better understand the unique properties of ACP-105, let’s compare it to a few other popular SARMs:
| SARM | Anabolic:Androgenic Ratio | Half-Life | Typical Dosage |
|---|---|---|---|
| ACP-105 | High anabolic selectivity[1] | 5 hours[1] | 10-20mg/day |
| Ostarine (MK-2866) | 3:1[5] | 24 hours[5] | 10-25mg/day |
| Testolone (RAD140) | 90:1[6] | 16-20 hours[6] | 10-20mg/day |
Where to Buy ACP-105
When purchasing ACP-105 or any research chemical, it’s crucial to choose reputable vendors that prioritize quality, purity, and third-party testing. Avoid suppliers that make unrealistic claims or lack transparency about their products. Stick with trusted vendors known for their commitment to providing high-quality, lab-tested SARMs.
ACP-105 Powder by Science.Bio
ACP-105 – Solution, 300mg (10mg/mL) by Science.Bio
Learn More: Amazon’s Fake/Counterfeit Supplement Problem
ACP-105 Discussions on Reddit
What do users on Reddit think about ACP-105? Here are some quotes from different discussions on the r/sarmssourcetalk subreddit:
- Bad experience with ACP-105: “Within a day, I felt immense brain fog and had a lingering headache. I kept going for about 4 days and the sides persisted so I stopped. Sides went away. Tried again a week later for only one day and the sides came back. Not trying it again. What’s going on here? Is it bunk product or is this how ACP-105 normally works?” – u/EquanimityForMe
- ACP-105 discussion as Pre-Workout Androgen: “ACP-105 vs MK-2866 Report. I ran ACP-105 for 8 weeks at 10mg ED and MK-2866 for 8 weeks at 25mg ED. Both cycles were separated by 8 weeks of PCT. Here are my results: ACP-105: Strength: +10% Muscle mass: +3kg Fat loss: -1kg Libido: Normal Sides: None MK-2866: Strength: +5% Muscle mass: +2kg Fat loss: -2kg Libido: Low Sides: Mild suppression, joint pain, acne Conclusion: ACP-105 is superior to MK-2866 in terms of strength and muscle gains, and has no noticeable side effects. MK-2866 is slightly better for fat loss, but has more sides and lower libido. I prefer ACP-105 and will use it again in the future.” – u/NSFW
- lets talk acp-105: “I rate ACP-105 at 5 mg aprx comparable to 20-25 mg of S4… give or take of course since you never REALLY know exactly how much you take. But 15 mg ACP-105 was quite like around 75 mg of S4 for me.” – u/AnabolicMinds
- Acp105?: “I love ACP-105. It gives me a dry hard look with fullness. Personally never have any sides from it, and never heard of any sides like the one you described from anyone I know who tried it. Different drugs affect different people differently so it can just be that you in particular have a bad response to Acp-105.” – u/Three-hit-sunshine
As you can see, ACP-105 has mixed reviews on Reddit. Some users report positive results, while others experience negative side effects. It is important to note that ACP-105 is an experimental drug that has not been tested for safety or efficacy in humans. Always consult your doctor before taking any supplements or drugs.
Frequently Asked Questions
Conclusion
ACP-105 is a promising SARM with potential benefits for cognitive enhancement, muscle growth, and fat loss. Its selective binding to androgen receptors in the brain and skeletal muscle allows for targeted effects while minimizing the risk of adverse reactions. However, as with any research chemical, caution and responsible use are paramount.
Before considering the use of ACP-105 or any other research chemical, it’s crucial to conduct thorough research, consult with healthcare professionals, and carefully weigh the potential benefits against the risks. Remember that the long-term effects of many SARMs, including ACP-105, are not yet fully understood, and more research is needed to establish their safety and efficacy profiles.
As we continue to explore the frontiers of cognitive enhancement and performance optimization, it’s essential to approach these compounds with a critical eye and a commitment to evidence-based practices. By staying informed, prioritizing safety, and adopting a holistic approach to health and wellness, we can make more informed decisions about our cognitive and physical enhancement strategies.
We encourage our readers to share their thoughts, experiences, and questions about ACP-105 in the comments section below. Your insights and perspectives contribute to our collective understanding and help foster a community of informed, health-conscious individuals dedicated to optimizing their cognitive and physical performance.
Remember, the journey to peak mental and physical performance is a personal one, and what works for one individual may not be suitable for another. Always prioritize your health and well-being, and don’t hesitate to seek professional guidance when considering any new supplement or performance-enhancing strategy.
References
[1] Schlienger N, Lund BW, Pawlas J, et al. Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators. J Med Chem. 2009;52(22):7186-7191. doi:10.1021/jm901149c https://pubmed.ncbi.nlm.nih.gov/19856921/
[2] Dayger C, Villasana L, Pfankuch T, Davis M, Raber J. Effects of the SARM ACP-105 on rotorod performance and cued fear conditioning in sham-irradiated and irradiated female mice. Brain Res. 2011;1381:134-140. doi:10.1016/j.brainres.2010.12.088 https://pubmed.ncbi.nlm.nih.gov/21219889/
[3] George S, Petit GH, Gouras GK, Brundin P, Olsson R. Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer’s disease. ACS Chem Neurosci. 2013;4(12):1537-1548. doi:10.1021/cn400133s https://pubmed.ncbi.nlm.nih.gov/24020966/
[4] Narayanan R, Coss CC, Dalton JT. Development of selective androgen receptor modulators (SARMs). Mol Cell Endocrinol. 2018;465:134-142. doi:10.1016/j.mce.2017.06.013 https://pubmed.ncbi.nlm.nih.gov/28624515/
[5] Geyer H, Schänzer W, Thevis M. Anabolic agents: recent strategies for their detection and protection from inadvertent doping. Br J Sports Med. 2014;48(10):820-826. doi:10.1136/bjsports-2014-093526 https://pubmed.ncbi.nlm.nih.gov/24632537/
[6] Jayaraman A, Christensen A, Moser VA, et al. Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology. 2014;155(4):1398-1406. doi:10.1210/en.2013-1725 https://pubmed.ncbi.nlm.nih.gov/24428527/
