The 15 Best Dopamine Supplements That Naturally Boost Happiness, Focus & Productivity

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The Best Dopamine Supplements

Dopamine makes you feel happy and rewarded.

Supplying adequate levels of dopamine is crucial for optimal brain health.

However, many people are dopamine deficient which can cause many problems in life.

For some people, dopamine deficiency is barely noticeable, while others go to extremes for hits of dopamine.

No other neurotransmitter affects human behavior quite like dopamine, which is why it’s imperative to get enough of it without having to resort to any high-risk activities.

Fortunately, there are nootropics and supplements that can boost dopamine.

This article discusses which nootropics are best for boosting and why they are so effective.

What Is Dopamine

Dopamine is the body’s reward neurotransmitter.

When the brain perceives a reward, it seeks the same experience to receive another. This reward system is the dynamics of learning and habit formation.¹

High levels of dopamine result in a feeling of pleasure, ease of movement, and motivation. Low levels of dopamine, on the other hand, results in low motivation and mood disorders.

Where Is Dopamine Made

Dopamine is made mostly in the hypothalamus, substantia nigra, and ventral tegmental area of the brain.²

However, recent research is discovering that up to 50% of dopamine comes from the gut!³

How Dopamine Works in the Brain

Healthy dopamine levels in the brain promote behavior and cognition, voluntary movement, motivation, punishment and reward, inhibition of prolactin production, sleep, dreaming, mood, attention, working memory, and learning.⁴

However, dopamine dysfunction due to oxidative stress causes depression, cognitive impairment, and other dopamine-related issues.

Brain plasticity is an important mechanism to adapt to sudden changes and stresses.⁵⁶

This mechanism affects the brain’s ability to develop, learn, and respond to various stimuli.⁷

How Nootropics Help Boost Dopamine

The future of nootropics to enhance brain function, learning and memory is bright. The use of natural nootropics has long-term effects on synaptic transmission and behavior as well.

Some nootropics promote the sprouting of neurites from a cell to improve synaptic communication in the brain.⁸

Nootropics protect the dopaminergic neurons to maintain a healthy level of dopamine.⁹

Nutrition is vital in boosting dopamine levels and achieving its desired outcome. Foods high in antioxidants and rich in nootropic agents is an effective way to manage age-related cognitive decline.¹⁰

Boosting dopamine and other neurotransmitters with nootropics can enhance brain function.

However, overstimulation of dopaminergic neurons can result in symptoms similar to low dopamine levels.¹¹

It’s wise to weigh the risks vs. rewards in your scenario when choosing to boost dopamine with nootropics.

Dopamine and Other Neurotransmitters

Dopamine also works with other neurotransmitters, especially acetylcholine, to boost learning and memory¹² and improve Parkinson’s disease symptoms.¹³

It also balances the effects of GABA,¹⁴ norepinephrine,¹⁵ and serotonin.¹⁶

Overall, dopamine is essential in maintaining mental health and learning-related functions.

Low dopamine symptoms

Cases of low dopamine are most recognizable through several easy-to-spot symptoms including

Mood Disorders: Depression/Anxiety
ADHD
Low Motivation

Mood (Depression)

Low levels of dopamine manifest as a reversal of feelings of pleasure, resulting in depressive mood and major depressive disorders.¹⁷

The feel-good sensation from a specific activity or substance induces the brain to release dopamine, which leads you to continue doing the action.

You feel the reward as pleasure, which keeps you coming back for more.

However, many factors can slow the flow of dopamine, leaving you in a lower mood.

Substance abuse, for example, causes low dopamine levels that show depressive symptoms and other behavioral changes.¹⁸

Seasonal changes also alter dopamine levels resulting in seasonal affective disorder (SAD).¹⁹

ADHD

Patients diagnosed with attention-deficit hyperactivity disorder (ADHD) exhibit low dopamine levels. The main symptoms are learning impairment, social dysfunction, a poor outlook in life, and substance abuse in adults.²⁰²¹

Other symptoms are low tolerance to stress, feelings of frustration, anger, and irritability. As a result, adults with ADHD tend to alienate themselves from friends, are rebellious, and have difficulty completing tasks.²²

Children with ADHD cannot sit still, are impatient, forget things and tasks, are talkative, impulsive, and easily distracted.

The job of many ADHD medications is to boost dopamine as a means of improving focus.

Low Motivation

Healthy dopamine levels arouse motivation to achieve a reward or incentive after an activity or eating a specific food item.²³

Motivation spurs a person into action, whether for sports, school, or work. It involves starting an activity, planning the necessary steps, consistency, and completing the task.²⁴

There’s also the factor of recognizing the reward, either external or internal.

Oxidative stress, manifested by inflammation, is one of the mechanisms that affect motivation.²⁵

Low motivation also affects decision-making, especially when you have to do a cost-benefit analysis of the decision you’re about to make.²⁶

Top Supplements

Mind Lab Pro

Mind Lab Pro is a nootropics stack with 11 ingredients known to boost brain function. Read more about Mind Lab Pro and its many benefits.

Citicoline, one of the main ingredients of Mind Lab Pro influences neurotransmitter systems, including dopamine. It helps manage withdrawal symptoms from substance abuse²⁷²⁸ and to improve overall cognitive function.²⁹ Phosphatidylserine helps to cope with stress,³⁰ manage depression,³¹ and improve memory functions.³²

Pycnogenol, an extract from maritime pine bark one of the ingredients of Mind Lab Pro works to improve brain function by protecting it from oxidative stress that causes inflammation and other disorders.³³

Qualia Mind

The powerful combination of close to 30 high-potency nootropics found in Qualia Mind all work together to improve dopamine levels to manage depression³⁴ and ADHD.³⁵. This stack includes dopamine-enhancing nootropics like DHA, uridine monophosphate Mucuna pruriens, DLPA, and NALT in Qualia Mind

It also contains Rhodiola Rosea Bacopa monnieri, ALCAR, and L-theanine that modulates cortisol response³⁶, minimizing anxiety and stress.³⁷

Several other ingredients also help improve cognitive functions. Phosphatidylserine and Celastrus paniculatus (the intellect plant) also help protect dopaminergic cells from damage due to chronic stress.³⁸³⁹

Read more to learn about how Qualia Mind targets significant brain pathways to enhance your mental health and learning.

L-Tyrosine (NALT)

The amino acid tyrosine is the precursor to dopamine, which means dopamine levels are dependent on tyrosine levels.⁴⁰

Chronic stress affects dopamine levels, but L-tyrosine supplementation effectively raises dopamine levels.⁴¹

Studies show that tyrosine enhances dopamine release and other neurotransmitters when the subject is under stress. On its own, tyrosine prevents cognitive function decline, promotes wakefulness, and lowers body negative pressure stress.⁴²

Conversely, tyrosine inhibitors’ administration decreases dopamine neurotransmission, which results in sleep deprivation and mood changes.⁴³

However, higher L-tyrosine levels show antidepressant effects concerning healthy dopamine, serotonin, and noradrenaline levels.⁴⁴

Not only that, dopamine-related tasks such as multitasking, updating of working memory, and inhibitory control improve with increased tyrosine levels in healthy humans.⁴⁵

Mucuna Pruriens

Seed extracts from Mucuna pruriens more commonly known as velvet bean, have high levodopa (L-dopa) levels, one of the dopamine precursors. It shows an antidepressant effect similar to the dopamine action.⁴⁶⁴⁷

Mucuna also shows antioxidant effects, which lowers inflammation as a result of high dopamine levels. Administration of dopamine-boosting medications lessens fatigue and related symptoms in patients with inflammation-associated diseases.⁴⁸

High levels of L-dopa from Mucuna seed extracts restore neurotransmission and protect dopaminergic cells.⁴⁹

Low levels of dopamine is closely related to parkinsonism and lessen symptoms like muscular rigidity.⁵⁰

L-dopa from Mucuna enhances dopamine production and relieves psychological stress.⁵¹

The resulting increase in dopamine levels also affects testosterone levels positively. Healthy testosterone levels, in turn, leads to improved sexual behavior, drive, and performance, which is also good for boosting mood.

Rhodiola Rosea

Investigation on the effectiveness of Rhodiola Rosea against stress, anxiety, and depression shows that Rhodiola increases dopamine, serotonin, and noradrenaline levels.⁵²⁵³

Several studies documented the effects of oral administration of Rhodiola extracts in anxiety, stress, cognition, and other mood symptoms. Subjects report reduction in symptoms from depression, anger, anxiety, and confusion and improvement in cognitive functions due to improved dopamine levels.⁵⁴⁵⁵

Rhodiola extract also shows potential in countering the ill effects of illicit drugs by balancing dopamine levels. Cocaine users show intense depression due to altered dopamine activity.⁵⁶

Another illegal drug, MPTP, kills dopaminergic neurons leading to low dopamine levels and an increase in free radicals in the brain.⁵⁷

It is also useful in improving depression from physical and mental fatigue,⁵⁸ in stimulating the immune system impaired by oxidative stress,⁵⁹ and enhancing learning and memory functions.⁶⁰

L-Theanine

L-theanine, a calming amino acid found in green tea contains many neuroprotective properties, useful for recovering from dopamine toxicity.

Substance abuse, for example, can result in altered dopamine activity and toxicity, which leads to serotonin degeneration,⁶¹ death of dopaminergic cells,⁶² and impaired mitochondrial action⁶³.

These cognitive impairments eventually manifest as depression, parkinsonism, and impaired cognitive functions.

L-theanine reverses dopamine neurotoxicity damage by activating astrocytes,⁶⁴⁶⁵ specialized cells responsible for regulating neurotransmitter release and control synapse formation.⁶⁶

The use of L-theanine supplements also improves symptoms of clinical depression, along with sleep disorders and cognitive impairment.⁶⁷⁶⁸

The effects of L-theanine on dopamine is dose-dependent.⁶⁹⁷⁰

A dose of 200mg enhances the brain’s alpha wave activity to induce relaxation without drowsiness.⁷¹

L-theanine’s long-term use also enhances GABA concentrations and brain-derived eurotrophic factor (BDNF), supporting its neuroprotective action concerning dopamine.⁷²

Probiotics

Probiotics can help boost dopamine and mood via the gut-brain axis. Since the gut produces around 50% of the dopamine that ends up in your brain, optimizing this vital link between the gut microbiome and your mind is crucial to producing dopamine and other neurotransmitters.⁷³

Alteration in the gut-brain axis affects the different pathways found along this axis.⁷⁴

Blocked neurological, metabolic, hormonal, and immunological pathways result in altered behavior, anxiety, and depressive symptoms, along with intestinal inflammation and inflammatory bowel diseases.

Clinical studies highlight the effects of a diseased gut and dopamine production.⁷⁵⁷⁶

Results include mental disorders like depression, anxiety, and Parkinson’s disease.

In another study, probiotics influence mood and cognitive functions⁷⁷⁷⁸ by improving sleep quality,⁷⁹ reducing anxiety, and enhancing mental response.⁸⁰

Omega 3 Supplements

Having adequate omega 3 stores are crucial to optimal dopamine levels.

In both human and animal studies, omega-3 fatty acids demonstrate increased dopamine levels, consequently improving depressive symptoms and dopaminergic function in the brain cortex.⁸¹⁸²⁸³⁸⁴

Like other dopamine-enhancing supplements, omega-3 fatty acids show potential in managing substance abuse. It can influence dopamine and other neurotransmitters to control impulsive behavior related to alcoholism.⁸⁵

Omega-3 fatty acids from krill⁸⁶ also enhance dopamine levels to modulate brain-derived neurotrophic factor (BDNF) and regulate the hypothalamic-pituitary-adrenal (HPA) axis to attenuate depressive symptoms.⁸⁷

Fish oil omega-3 fatty acids, on the other hand, restores dopamine release in the striatum after a traumatic brain injury by effectively reducing inflammation.⁸⁸

Magnesium

Dopamine is one of the more prominent causes of various neurological disorders like Parkinson’s and Alzheimer’s disease. Aside from low dopamine levels in these conditions, magnesium concentrations are also deficient.⁸⁹

Magnesium supplementation slows down dopamine neuron loss and improves motor skills in Parkinson’s disease models, showing magnesium’s potential as a therapeutic alternative.⁹⁰⁹¹

By inhibiting glutamate action⁹² that causes dopaminergic cell death,⁹³ magnesium helps increase dopamine to manage depression better.

Substance abuse promotes the release of dopamine in the body until it reaches toxic levels. Magnesium helps by regulating dopamine levels, the body’s primary reward neurotransmitter, and inhibits excitation caused by glutamates.⁹⁴⁹⁵

Taurine

Taurine and dopamine have a two-way effect on each other as both can inhibit the other’s release under certain conditions.⁹⁶

However, it did show to influence dopamine action in easing symptoms of neurodegenerative diseases.⁹⁷

It also protects the dopaminergic neural cells by preventing inflammation in the central nervous system.

The effects of taurine are dose-dependent. A high dose of taurine showed improved dopamine uptake and potential as a treatment for ADHD.⁹⁸

Taurine administration also effectively increases BDNF levels, which help in effective communication between the spine and the brain.⁹⁹

Green Tea Extract

Green tea has many components, each acting to either improve or inhibit dopamine action. For example, glycine induces dopamine release¹⁰⁰, while L-theanine helps improve mood by enhancing dopamine action.¹⁰¹

Tea is a time-honored tradition of the Japanese people, and scientific findings show that they were right about it. Regular green tea consumption leads to low depressive symptoms among the elderly.¹⁰²

Drinking green tea regularly exhibits less stress, inflammation, and depressive symptoms. It also improves the brain’s ability to form new neural connections to adapt to changes and situations (neuroplasticity).¹⁰³

ALCAR Acetyl L-Carnitine

Acetyl L-carnitine also known as ALCAR or L-carnitine, preserves taurine in the brain, increasing dopamine levels, especially in the aging brain.¹⁰⁴

L-carnitine increases dopamine receptors to prevent neuronal cell death and improve subjects’ cognitive function.¹⁰⁵

It also augments dopamine output to protect the brain from acute stress exposure. To sustain its neuroprotective effects, maintain L-carnitine use.¹⁰⁶

Aside from dopamine, L-carnitine also influences other neurotransmitters that either attenuate or ameliorate dopamine release. Imbalance in these neurotransmitters results in major depressive disorder and other neurodegenerative illnesses.

DLPA

DL-phenylalanine (DLPA) is an amino acid supplement (synthetic phenylalanine) known for its benefits in pain management, mood regulation, and cognitive functions.¹⁰⁷

As a dopamine precursor, phenylalanine influences the reward/punishment processing of recovering depressed patients.¹⁰⁸¹⁰⁹

Imbalance in phenylalanine levels, especially in the case of phenylketonuria, induces depression because overly high phenylalanine in the blood depletes dopamine levels.¹¹⁰

However, phenylalanine also balances dopamine levels in people suffering from withdrawal symptoms from substance abuse.

Administration of tyrosine/phenylalanine-depleted drinks for people suffering from withdrawal symptoms reduces aggression, hallucinations, nausea, and depression.¹¹¹

Uridine Monophosphate

Uridine monophosphate enhances dopamine production and induces neurite growth.¹¹²

Neurite growth and branching helps in achieving an adequately wired neuronal network to improve communication in the brain.¹¹³

Dopamine, in turn, helps in proper neurite branching, targeting specific neurons, and synapse formation¹¹⁴, which predicts mental health status.¹¹⁵

Uridine, in combination with DHA, restores and releases dopamine in the striatum.¹¹⁶

Uridine monophosphate administration (500mg twice daily) can also effectively reduce suicidal ideation in bipolar patients.¹¹⁷

Reishi Mushroom

Reishi mushroom (Ganoderma lucidum) is a known traditional Chinese medicine used to prevent inflammation, leading to the death of dopaminergic cells.¹¹⁸

Reishi contains antidepressant properties by regulating the central nervous system and acting as a sedative.¹¹⁹

Dopamine from Reishi mushroom plays a role in epilepsy through its D2 receptors¹²⁰and inhibiting calcium overload.¹²¹¹²²

By protecting the dopaminergic neurons from degeneration, Reishi mushroom also reduces symptoms of Parkinson’s disease.

Wrapping It Up

Dopamine is essential in maintaining optimal mental health.

Fortunately, there are plenty of nootropics and supplements that can help boost your dopamine if you’re low.

It’s important to remember that both low and excessive dopamine levels display identical symptoms.

So, before taking dopamine-boosting supplements, take caution that the symptoms you experience points to low dopamine levels.

While some supplements work for some people, not all work the same for all people.

Be your own study subject and experiment to find which nootropic works best for you.

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The 15 Best Natural Dopamine Supplements | Boost Happiness, Focus & Productivity

Biohack Your Brainpower

The Best Dopamine Supplements

What Is Dopamine

Where Is Dopamine Made

How Dopamine Works in the Brain

How Nootropics Help Boost Dopamine

Dopamine and Other Neurotransmitters

Low dopamine symptoms

Mood (Depression)

ADHD

Low Motivation

Top Supplements

Mind Lab Pro

Qualia Mind

L-Tyrosine (NALT)

Mucuna Pruriens

Rhodiola Rosea

L-Theanine

Probiotics

Omega 3 Supplements

Magnesium

Taurine

Green Tea Extract

ALCAR Acetyl L-Carnitine

DLPA

Uridine Monophosphate

Reishi Mushroom

Wrapping It Up

Biohack Your Brainpower

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TOP 5 in BIOHACKING

Apollo Wearable by Apollo Neuro

SaunaSpace

NeoRhythm by OmniPEMF

Lumen Metabolism Tracker

K-Tropix

A note about our content:

Connect with us!

Holistic Nootropics1632 1st Ave #24775New York, NY 10028USA

+1 (480) 918-7745

Holistic Nootropics
1632 1st Ave #24775
New York, NY 10028
USA